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PEGylation

    PEGylation is the process of attaching the strands of the polymer PEG to molecules, most typically peptides, proteins, and antibody fragments, that can improve the safety and efficiency of many therapeutics.  It produces alterations in the physiochemical properties including changes in conformation, electrostatic binding, hydrophobicity etc. These physical and chemical changes increase systemic retention of the therapeutic agent. Also, it can influence the binding affinity of the therapeutic moiety to the cell receptors and can alter the absorption and distribution patterns.
    Biochempeg PEGylation linkers, by increasing the molecular weight of a molecule, can impart several significant pharmacological advantages over the unmodified form, such as improved drug solubility, reduced dosage frequency, without diminished efficacy with potentially reduced toxicity, extended circulating life, increased drug stability, and enhanced protection from proteolytic degradation
Biochempeg provide bulk maleimide,  pyridyl disulfide, amine, carboxylic acids and NHS esters  functionalized PEG which can linked with proteins, typical reactive amino acids include lysine, cysteine, histidine, arginine, aspartic acid, glutamic acid, serine, threonine, tyrosine.

     Technique support: GMP standard production support, parameters control. Contact for Technical Files and OEM details.

 

Catalog No. Name Structure M.W. Purity
MF001005 mPEG-NH2 mPEG-NH2 ≥95%
MF001003 mPEG-SH mPEG-SH ≥95%
MF001009 mPEG-AC mPEG-AC ≥95%
MF001022 mPEG-Mal mPEG-Mal ≥95%
MF001024 mPEG-SCM mPEG-SCM ≥95%
HO003003 SH-PEG-SH SH-PEG-SH ≥95%
HO005005 NH2-PEG-NH2 NH2-PEG-NH2 ≥95%
HO022022 Mal-PEG-Mal Mal-PEG-Mal ≥95%
HE002005 OH-PEG-NH2 OH-PEG-NH2 ≥95%
MF001096 mPEG-DSPE mPEG-DSPE ≥95%
MD005005 NH2-PEG8-NH2 NH2-PEG8-NH2 412.5 ≥95%
MD005005 NH2-PEG12-NH2 NH2-PEG12-NH2 588 ≥95%