In PDAC, the early onset of hypoxia triggers extracellular matrix remodeling, epithelial to mesenchymal transition, increased cell survival, cancer stem cell formation, and drug resistance. Hypoxia in PDAC is also related to the development of collagen-rich fibrous extracellular matrix (desmoplasia), leading to damaged drug penetration severely. We created polymer nanoparticles (polymersomes) to overcome these difficult challenges, that can target and penetrate pancreatic tumors.
Vitro studies have shown that compared with unencapsulated drugs, under hypoxic conditions, the cellular uptake of polymersomes is higher, and the cytotoxicity of the drug is increased. Compared with the untreated control group, the polymersomes decreased tumor growth in mice by nearly 250% and significantly increased intratumoral necrosis by 60%. It is anticipated that these polymer nanoparticles have considerable translational potential for drug delivery to solid hypoxic tumors.
Source: Targeting the Tumor Core: Hypoxia-Responsive Nanoparticles for the Delivery of Chemotherapy to Pancreatic Tumors
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