Release date:2021/1/19 4:10:07
According to a large number of documents prepared by the World Health Organization(WHO) regarding COVID-19 candidate vaccines globally, there are 44 candidate vaccines in clinical trials, 10 of which are in Phase III (Table 1). In addition, there are 154 candidate vaccines in the preclinical stage worldwide.
ten candidate vaccines
Table 1. Ten candidate vaccines in Phase III clinical trial.
Draft landscape of COVID-19 candidate vaccines 
On December 11, 2020, the
FDA issued the first emergency use authorization (EUA) for a vaccine for the prevention of COVID-19 caused by SARS-CoV-2 in individuals 16 years of age and older. The EAU allows the Pfizer-BioNTech COVID-19 Vaccine to be distributed in the U.S.
After Pfizer's COVID-19 vaccine received Emergency Use Authorization (EUA) from the FDA, an FDA panel deemed the COVID-19 candidate vaccine from Moderna are “highly effective” with no serious allergic reactions observed. It is probably the
FDA will issue an EUA for the Moderna candidate vaccine any time now clearing the way for the vaccine to be distributed and administered nationwide.
What are the ingredients of those two kind of COVID-19 Vaccines?
Ingredients of Pfizer COVID-19 Vaccine
Active Ingredient:
·30 mcg nucleoside modified messenger RNA (modRNA) encoding the viral spike glycoprotein of SARS-CoV-2.
Fats (Lipids):
·0.43 mg (4-hydroxybutyl)azanediyl)bis(hexane-6,1-diyl)bis(2-hexyldecanoate)
·0.05 mg 2[(polyethylene glycol)-2000]-N,N-ditetradecylacetamide
·0.09 mg 1,2-distearoyl-sn-glycero-3-phosphocholine
·0.2 mg cholesterol
·0.01 mg potassium chloride
·0.01 mg monobasic potassium phosphate
·0.36 mg sodium chloride
·0.07 mg dibasic sodium phosphate dihydrate
·6 mg sucrose

Ingredients in the Moderna COVID-19 Vaccine

Active Ingredient:
·Synthetic messenger ribonucleic acid (mRNA) encoding the pre-fusion stabilized spike glycoprotein (S) of SARS-CoV-2 virus.
Fats (Lipids):
·1,2-dimyristoyl-rac-glycero3-methoxypolyethylene glycol-2000 [PEG2000-DMG]
·1,2-distearoyl-snglycero-3-phosphocholine [DSPC]
Other Excipients:
·tromethamine hydrochloride
·acetic acid
·sodium acetate
What are the application technology of those two kind of COVID-19 Vaccines?
Lipid nanoparticles are present in a COVID-19 vaccine. These nanoparticles are tiny lipid droplets that can transport and protect vaccine components. The
lipid nanoparticles in the COVID-19 vaccine are there to transport RNA molecules.
An excipient is a substance formulated with the active ingredient of a drug for the purpose of long-term stabilization, bulking up solid formulations that contain small amounts of potent active ingredients, or to enhance the therapeutic effect on the active ingredient in the final dosage form, such as facilitating drug absorption, reducing viscosity, or enhancing solubility.
PEGylated lipids can be used as excipients in both the Pfizer–BioNTech vaccine and the Moderna vaccine for SARS-CoV-2. Both RNA vaccines consist of Messenger RNA, or mRNA, encased in a bubble of oily molecules called lipids. Proprietary lipid technology is used for each vaccines. In both vaccines, the bubbles are coated with stable molecule of polyethylene glycol.
As a leading worldwide supplier of PEG & ADC linkers,
Biochempeg supplies a variety of high purity PEG derivatives, PEG linkers and ADC linkers to empower drug research & development. 

Draft landscape of COVID-19 candidate vaccines
[2] Pfizer COVID-19 Vaccine List of Ingredients
[3] Moderna COVID-19 Vaccine List of Ingredients 

Previous:Nature Medicine: Top Ten Advancements in Biomedicine in 2020 Next:Basic Information About Sacituzumab Govitecan