A Covalently Crosslinked Bioink Used In Three-dimensional Cell Cultures of 3D Bioprinting

A three-dimensional (3D) cell culture is an artificially created environment in which biological cells are permitted to grow or interact with their surroundings in all three dimensions. A 3D cell culture allows cells in vitro to grow in all directions, similar to how they would in vivo. Compared with 2D cell culture, in vitro 3D cell models can better recapitulate aspects in vivo organ environment. At present, the production of 3D cell models in vitro remains challenging.

There is a versatile bio-ink consisting of a 4-arm PEG based polymer with distal maleimide derivatives as the main ink component, and a bis-thiol species as the activator that can cross-link the polymer to form a hydrogel in less than a second. Rapid gelation makes the polymer system compatible with 3D bioprinting.

For more information, please read the details at https://www.biorxiv.org/content/10.1101/2021.02.18.431759v1.

Multi-Arm PEG product is a unit smart cross-linker which is wide studied in medical field and bioorganic material fields, such as preparation of gel, drug development, 3D cell culture and so on. Biochempeg supply totally different multi-arm PEG linkers, as well as 2-arm peg, 4-arm peg or 8-arm PEG with MW 2k, MW 5k, MW 10k, MW 20k and MW 40k, in 1g, 5g or greater packing sizes.

Our related product: 4-ArmPEG-maleimide