Monodisperse PEGs

Monodisperse PEG products usually are organic compounds with a molecular weight of less than 1000. Biochempeg's Monodisperse PEGs do not have the polydispersity of general PEG polymers, and retain the good solubility of polyethylene glycol in water. It can also impart flexibility, anticoagulation, anti-macrophage phagocytosis, etc., to modified biomolecules. This provides PEGylated drugs with the same PEG that reduces polymerization and immunogenicity.

Monodispersed PEGs have been applied in many fields, including medical research, drug-release, nanotechnology, etc. And they have been become very beneficial in drug design and development, specifically in the antibody-drug conjugates and small molecule drugs

Why Monodispersed PEGs Can Help?
Improved pharmacokinetics: Enhanced solubility; improved stability.
 Increased circulation time: Decreased amount of drug required; decreased dosing frequency; reduced renal clearance increases circulation time.
• Decreased toxicity: Improved safety profile; reduced immunogenicity; reduced antigenicity; reduced proteolysis.

Biopharma PEG continuously expands its capability to provide large-scale manufacture of high purity monodisperse PEG derivatives with an extensive variety of functional groups, such as mPEG36-NH2, N3-PEG3-SPA, NH2-PEG3-OH, and NH2-PEG24-COOH etc.

Find more Biochempeg scaled-up monodisperse PEG derivatives.

1. Kinbara, K. Monodisperse engineered PEGs for bio-related applications. Polym J 50, 689–697 (2018).

Catalog No. Name Structure M.W. Purity
MD329050 Thalidomide-O-PEG5-NH2.HCl Thalidomide-O-PEG5-NH2.HCl 574.02 ≥95%
MD288005 Pomalidomide-PEG4-NH2 Pomalidomide-PEG4-NH2 492.52 ≥95%
MD288065 Pomalidomide-PEG4-Ph-NH2 Pomalidomide-PEG4-Ph-NH2 540.57 ≥95%
MD286050 Thalidomide-O-amido-PEG1-NH2.HCl Thalidomide-O-amido-PEG1-NH2.HCl 454.86 ≥95%
MD286050 Thalidomide-O-amido-PEG2-NH2.HCl Thalidomide-O-amido-PEG2-NH2.HCl 498.92 ≥95%
MD286123 Thalidomide-O-amido-PEG2-NH2.TFA Thalidomide-O-amido-PEG2-NH2.TFA 576.48 ≥95%
MD329025 Thalidomide-O-PEG2-SPA Thalidomide-O-PEG2-SPA 531.47 ≥95%
MD329025 Thalidomide-O-PEG4-SPA Thalidomide-O-PEG4-SPA 619.57 ≥95%
MD329007 Thalidomide-O-PEG2-Propargyl Thalidomide-O-PEG2-Propargyl 400.38 ≥95%
MD329007 Thalidomide-O-PEG4-Propargyl Thalidomide-O-PEG4-Propargyl 488.49 ≥95%
MD329005 Thalidomide-O-PEG4-NH2 Thalidomide-O-PEG4-NH2 493.51 ≥95%
MD329006 Thalidomide-O-PEG4-N3 Thalidomide-O-PEG4-N3 519.51 ≥95%