Biopharma PEG provides custom synthesis, process development, and scale-up manufacturing of high-quality Polyethylene Glycol (PEG) derivatives for pharmaceutical and biotechnology companies.
We specialize in the design and production of functionalized PEG derivatives, high-purity monodisperse (discrete) PEGs, and multi-arm architectures. We can supply PEG products from milligrams to multi-kilogram scale, with high purity, structural accuracy, and strict quality control—ideal for applications in Antibody-Drug Conjugates (ADCs), PROTACs, Lipid Nanoparticles (LNPs), peptides, oligonucleotides, and hydrogel formulations, etc.
Custom PEG Synthesis Capabilities
Our custom synthesis platform supports a wide range of chemistries and architectures for PEGs.
A. Functional PEG Derivatives
We offer PEG derivatives with a broad spectrum of functional groups (200 Da - 43 kDa):
- ● Reactive Groups: NHS Esters, Maleimide, Carboxylic Acid, Amine, Thiol, Aldehyde, Hydroxyl, etc.
- ● Lipid-PEGs: DSPE, DOPE, DMG, Cholesterol, etc
- ● Click Chemistry: Azide (N3), Alkyne, DBCO, etc
- ● Fluorescent Labeling: Cy3, Cy5, Cy7, FITC, etc.
- ● Heterobifunctional & Homobifunctional PEGs: Precise control over end-group functionalization.
B. Monodisperse PEG (Discrete PEG)
Specialized synthesis of high-purity, single-molecular-weight PEGs.
- ● Defined molecular weight
- ● Narrow polydispersity
- ● Batch-to-batch uniformity
- ● Tight impurity control
- ● High analytical confidence
C. Custom PEG Architectures
- ● Linear PEGs (Monofunctional, Heterobifunctional & Homobifunctional)
- ● Y-shape PEGs
- ● Multi-Arm PEGs (4-arm, 8-arm)
Reactive PEGs. source: DOI:10.1590/s2175-97902018000001009
Scale-Up & Manufacturing (mg → g → kg → 100+ kg)
Biopharma PEG supports projects from milligram research quantities to multi-kilogram and commercial production. All manufacturing is conducted under strict process controls and well-established quality standards.
We provide both non-GMP and GMP-grade PEG derivatives through custom synthesis, enabling customers to meet specific technical and regulatory requirements.
Analytical & Quality Control
Every custom synthesized product undergoes a strict quality assessment using advanced instrumentation:
- ● NMR (400 MHz)
- ● HPLC / SEC-HPLC / RP-HPLC
- ● MALDI-TOF MS / LC-MS / GC-MS
Analytical rigor ensures identity, purity, and reproducibility across batches.
Connect with our team to discuss your specific requirements. Email: sales@biochempeg.com.