- PEGs by Application
- PEGs by Structure
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PEG Linkers
- >PROTAC Linker
- >Methoxy PEG (mPEG)
- >Amine(NH2) PEG
- >DSPE PEG
- >Thiol(SH) PEG
- >Maleimide(Mal) PEG
- >DBCO PEG
- >Azide(N3) PEG
- >Carboxylic Acid(COOH) PEG
- >Acrylate(AC) PEG
- >Cyanine (Cy) PEG
- >NHS ester PEG
- >Biotin PEG
- >Aldehyde (Ald/CHO)PEG
- >Other Lipid PEG
- >Fluorescent (FITC) PEG
- >Cholesterol PEG
- >Hydroxyl(OH) PEG
- >OPSS PEG
- >Acrylamide(ACA) PEG
- >Epoxide (EPO) PEG
- >Hydrazide (HZ) PEG
- >Boc/Fmoc PEG
- > Folic Acid(FA) PEG
- >Lipoic acid(LA) PEG
- >Halide (F,Cl,Br,I) PEG
- >Methacrylate (MA) PEG
- >Rhodamine B(RB) PEG
- >Silane PEG
- >PLGA PEG
- >PCL PEG
- >PLA PEG
- >PEG Sulfonic acid
- >PEG PFP ester
- >PEG TFP ester
- >Benzyl-PEG
- >Aminooxy PEG
- >Hydrocarbons PEG
- >Nitrophenyl Carbonate (NPC) PEG
- >DNP PEG
- >Other PEG
- PEG in mRNA Vaccines
- PEG Raw Material
- Large Scale PEGs
Of all approved COVID-19 vaccines in the market, the vaccines developed by BioNTech/Pfizer and Moderna represent a new class of vaccine products: they are composed of messenger ribonucleic acid (mRNA) strands encapsulated in lipid nanoparticles (LNPs).
The LNPs in mRNA covid-19 vaccines consist of four main components: a neutral phospholipid, cholesterol, a polyethylene-glycol (PEG)-lipid, and an ionizable cationic lipid, among them, PEG lipids can have multiple effects on the properties of lipid nanoparticles.
- Increase particle stability by decreasing particle aggregation;
- Prolong the blood circulation time of nanoparticles by reducing clearance mediated by the kidneys and the mononuclear phagocyte system (MPS);
- Conjugate specific ligands to the particle for targeted delivery.
Biopharma PEG is a dynamic science company dedicated to PEG derivatives. We are capable of supplying small to large quantities of a rich selection of PEG derivatives with GMP & non-GMP standards for your mRNA vaccine R&D. We can produce and provide the following PEG products for your mRNA vaccines R&D.
References:
1. Hou, X., Zaks, T., Langer, R. et al. Lipid nanoparticles for mRNA delivery. Nat Rev Mater 6, 1078–1094 (2021). https://doi.org/10.1038/s41578-021-00358-0
2. Schoenmaker, Linde, et al., mRNA-lipid nanoparticle COVID-19 vaccines: structure and stability, International Journal of Pharmaceutics 601 (2021).