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Monodispersed PEGs
- >Methoxy PEG (mPEG)
- >Azide(N3) PEG
- >Amine(NH2) PEG
- >Hydroxyl(OH) PEG
- >Thiol(SH) PEG
- >Boc/Fmoc PEG
- >Carboxylic Acid(COOH) PEG
- >Maleimide(Mal) PEG
- >Alkyne PEG
- >NHS ester PEG
- >Biotin PEG
- >Aldehyde (Ald/CHO)PEG
- >Acrylate(AC) PEG
- >Acrylamide(ACA) PEG
- >DBCO PEG
- >DSPE PEG
- >Other Lipid PEG
- >Epoxide (EPO) PEG
- >Hydrazide (HZ) PEG
- >Folic Acid(FA) PEG
- >Lipoic acid(LA) PEG
- >Methacrylate (MA) PEG
- >Silane PEG
- >PEG Sulfonic acid
- >PEG PFP ester
- >PEG TFP ester
- >Halide (F,Cl,Br,I) PEG
- >Benzyl-PEG
- >Aminooxy PEG
- >Fluorescent (FITC) PEG
- >Rhodamine B(RB) PEG
- >Cholesterol PEG
- >OPSS PEG
- >Nitrophenyl Carbonate (NPC) PEG
- >DNP PEG
- >Other PEG
- >PROTAC Linker
- >Hydrocarbons PEG
- >View More
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Polydispersed PEGs
- >Methoxy PEG (mPEG)
- >Azide(N3) PEG
- >Amine(NH2) PEG
- >Hydroxyl(OH) PEG
- >Thiol(SH) PEG
- >DSPE PEG
- >Carboxylic Acid(COOH) PEG
- >Maleimide(Mal) PEG
- >NHS ester PEG
- >Acrylate(AC) PEG
- >Boc/Fmoc PEG
- >Biotin PEG
- >Aldehyde (Ald/CHO)PEG
- >Fluorescent (FITC) PEG
- >Cyanine (Cy) PEG
- >Epoxide (EPO) PEG
- >Hydrazide (HZ) PEG
- >Silane PEG
- >Cholesterol PEG
- >DBCO PEG
- >Alkyne PEG
- >Nitrophenyl Carbonate (NPC) PEG
- >OPSS PEG
- >Acrylamide(ACA) PEG
- >PLGA PEG
- >PCL PEG
- >PLA PEG
- >PEG Sulfonic acid
- >PEG PFP ester
- >Halide (F,Cl,Br,I) PEG
- >Aminooxy PEG
- >Folic Acid(FA) PEG
- >Lipoic acid(LA) PEG
- >Methacrylate (MA) PEG
- >Rhodamine B(RB) PEG
- >Other Lipid PEG
- >Other PEG
- >Hydrocarbons PEG
- >View More
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Multi-arm PEGs
- >Hydroxyl(OH) PEG
- >NHS ester PEG
- >Amine(NH2) PEG
- >Maleimide(Mal) PEG
- >Azide(N3) PEG
- >Thiol(SH) PEG
- >DBCO PEG
- >Carboxylic Acid(COOH) PEG
- >Aldehyde (Ald/CHO)PEG
- >Methoxy PEG (mPEG)
- >Acrylate(AC) PEG
- >Biotin PEG
- >Cholesterol PEG
- >OPSS PEG
- >Acrylamide(ACA) PEG
- >Epoxide (EPO) PEG
- >Hydrazide (HZ) PEG
- >Folic Acid(FA) PEG
- >Lipoic acid(LA) PEG
- >Methacrylate (MA) PEG
- >Silane PEG
- >Halide (F,Cl,Br,I) PEG
- >Nitrophenyl Carbonate (NPC) PEG
- >Other PEG
- >View More
- >Hydrocarbons PEG
- PEGs by Application
- Lipid Nanoparticle (LNP) Lipids
- Nucleic Acid Chemistry
- PEG Raw Material
- On Sale PEG Linkers
- Recombinant Proteins
Lipid Nanoparticles (LNPs) are delivery systems commonly employed in the field of nucleic acid drugs. The LNP technology has been adopted for COVID-19 vaccine manufacture. LNPs mainly contain four components: a neutral phospholipid, cholesterol, a polyethylene-glycol (PEG)-lipid, and an ionizable cationic lipid. Among them, cholesterol is often included as a helper lipid that improves intracellular delivery as well as LNP stability in vivo and the PEGylated lipid can enhance LNP colloidal stability in vitro and circulation time in vivo.
Biopharma PEG is a dynamic science company dedicated to supplying excipients for your LNP formulation development. We are capable of supplying small to large quantities of a rich selection of PEG derivatives and cholesterol with GMP & non-GMP standards for your mRNA vaccine R&D.
References:
1. Hou, X., Zaks, T., Langer, R. et al. Lipid nanoparticles for mRNA delivery. Nat Rev Mater 6, 1078–1094 (2021). https://doi.org/10.1038/s41578-021-00358-0
2. Schoenmaker, Linde, et al., mRNA-lipid nanoparticle COVID-19 vaccines: structure and stability, International Journal of Pharmaceutics 601 (2021).
