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Lipid PEGs

​Polyethylene glycol (PEG)-lipid conjugates are PEG derivatives containing lipid molecules such as DMG or DSPE, which have been used in bioconjugation, and lipid nanoparticle (LNP) drug delivery to improve circulation times for liposome-encapsulated drugs. The lipid molecule has the characteristics of low toxicity and easy preparation, and it can not only be used as a carrier for water-soluble drugs, but also as a carrier for fat-soluble drugs. 

PEG lipids can significantly influence the properties of lipid nanoparticles in various ways:
1. Particle Size: The amount of PEG lipids can affect the size of the nanoparticles.
2. Particle Stability: By decreasing particle aggregation, PEG lipids enhance the stability of the nanoparticles.
3. Blood Circulation Time: Optimizing PEG can prolong the blood circulation time of nanoparticles by reducing clearance by the kidneys and the mononuclear phagocyte system.
4. Targeted Delivery: PEG lipids can also be used to attach specific ligands to the nanoparticles, allowing for targeted delivery.

Biopharma PEG's Lipid PEG can be used in lipid nanoparticle delivery, bioconjugation, etc. It is a product with a wide range of applications. PEG lipids are used as an excipient in both the Moderna/Pfizer-BioNTech COVID-19 mRNA vaccines.  Biopharma PEG now offers an extensive group of PEG-lipid conjugates incorporating various functionalized PEG terminals, like Amine, Carboxylic acid, Azide, Aldehyde, Thiol, and Hydroxy.

Besides PEG lipids, we can also provide helper lipids, such as cholesterol, totally derived from plants, and DSPE for your LNP formulation development. 

References:
​Gill KK, Kaddoumi A, Nazzal S. PEG-lipid micelles as drug carriers: physiochemical attributes, formulation principles and biological implication. J Drug Target. 2015 Apr;23(3):222-31. doi: 10.3109/1061186X.2014.997735. Epub 2014 Dec 30. PMID: 25547369.

Catalog No. Name Structure M.W. Purity
MD095005 CLS-PEG8-NH2 CLS-PEG8-NH2 881.23 ≥95%
MD095022 CLS-PEG4-NH-Mal CLS-PEG4-NH-Mal 856.14 ≥95%
MD096017 DSPE-PEG14-COOH DSPE-PEG14-COOH ≥95%
MD096141 DSPE-PEG6-Mal DSPE-PEG6-Mal 1163.5 ≥95%
MD098022 DPPE-PEG2-NH-Mal DPPE-PEG2-NH-Mal ≥95%
MF001096 mPEG-DSPE mPEG-DSPE ≥95%
MF001182 mPEG-DSPE(ammonium salt) mPEG-DSPE(ammonium salt) ≥95%
MF001097 mPEG-DMPE mPEG-DMPE ≥95%
LP001284 mPEG-DMPE(ammonium salt) mPEG-DMPE(ammonium salt) ≥95%
LP001100 mPEG-DOPE mPEG-DOPE ≥95%
MF001098 mPEG-DPPE mPEG-DPPE ≥95%
MF001099 mPEG-DLPE mPEG-DLPE ≥95%