PEG Lipids for Target Drug Delivery- Biochempeg

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Lipid PEGs

Polyethylene glycol (PEG)-lipid conjugates are PEG derivatives containing lipid molecules such as DMG or DSPE, which have been used in bioconjugation, and lipid nanoparticle (LNP) drug delivery to improve circulation times for liposome-encapsulated drugs. The lipid molecule has the characteristics of low toxicity and easy preparation, and it can not only be used as a carrier for water-soluble drugs, but also as a carrier for fat-soluble drugs.

PEG lipids can significantly influence the properties of lipid nanoparticles in various ways:
1. Particle Size: The amount of PEG lipids can affect the size of the nanoparticles.
2. Particle Stability: By decreasing particle aggregation, PEG lipids enhance the stability of the nanoparticles.
3. Blood Circulation Time: Optimizing PEG can prolong the blood circulation time of nanoparticles by reducing clearance by the kidneys and the mononuclear phagocyte system.
4. Targeted Delivery: PEG lipids can also be used to attach specific ligands to the nanoparticles, allowing for targeted delivery.

Biopharma PEG's Lipid PEG can be used in lipid nanoparticle delivery, bioconjugation, etc. It is a product with a wide range of applications. PEG lipids are used as an excipient in both the Moderna/Pfizer-BioNTech COVID-19 mRNA vaccines. Biopharma PEG now offers an extensive group of PEG-lipid conjugates incorporating various functionalized PEG terminals, like Amine, Carboxylic acid, Azide, Aldehyde, Thiol, and Hydroxy.

Besides PEG lipids, we can also provide helper lipids, such as cholesterol, totally derived from plants, and DSPE for your LNP formulation development.

References:
Gill KK, Kaddoumi A, Nazzal S. PEG-lipid micelles as drug carriers: physiochemical attributes, formulation principles and biological implication. J Drug Target. 2015 Apr;23(3):222-31. doi: 10.3109/1061186X.2014.997735. Epub 2014 Dec 30. PMID: 25547369.

Catalog No.	Name	Structure	M.W.	Purity	Buy
MD095005	CLS-PEG8-NH2		881.23	≥95%

MD095022	CLS-PEG4-NH-Mal		856.14	≥95%

MD096017	DSPE-PEG14-COOH			≥95%

MD096141	DSPE-PEG6-Mal		1163.5	≥95%

MD098022	DPPE-PEG2-NH-Mal			≥95%

MF001096	mPEG-DSPE			≥95%

MF001182	mPEG-DSPE(ammonium salt)			≥95%

MF001097	mPEG-DMPE			≥95%

LP001284	mPEG-DMPE(ammonium salt)			≥95%

LP001100	mPEG-DOPE			≥95%

MF001098	mPEG-DPPE			≥95%

MF001099	mPEG-DLPE			≥95%

MF001102	mPEG-DEPE			≥95%

MF001095	mPEG-CLS			≥95%

LP001226	mPEG-Palmitic acid			≥95%

MF001101	mPEG-STA			≥95%

LP096282	DSPE-PEG-Mannose			≥95%

LP096022	DSPE-PEG-Mal			≥95%

LP096005	DSPE-PEG-NH2			≥95%

LP287005	DSPE(Sodium salt)-PEG-NH2			≥95%

LP287002	DSPE(Sodium salt)-PEG-OH			≥95%

LP096338	DSPE-PEG-6-O-glucose			≥95%

LP096009	DSPE-PEG-AC			≥95%

LP096010	DSPE-PEG-ACA			≥95%

LP096007	DSPE-PEG-Alkyne			≥95%

LP096041	DSPE-PEG-Biotin			≥95%

LP096262	DSPE-PEG-c(RGDyK)			≥95%

LP096095	DSPE-PEG-CLS			≥95%

LP096017	DSPE-PEG-COOH			≥95%

LP096167	DSPE-PEG-Cy3			≥95%

LP096078	DSPE-PEG-Cy5			≥95%

FL096079	DSPE-PEG-CY5.5			≥95%

LP096296	DSPE-PEG-Cy7.5			≥95%

LP096048	DSPE-PEG-DBCO			≥95%

HO096096	DSPE-PEG-DSPE			≥95%

LP096208	DSPE-PEG-Estrogen			≥95%

LP096057	DSPE-PEG-FA

FL096044	DSPE-PEG-FITC			≥95%

LP096072	DSPE-PEG-Galactose			≥95%

LP096297	DSPE-PEG-Glucose			≥95%

LP096348	DSPE-PEG-Glycine triarginine			≥95%

LP096019	DSPE-PEG-HZ			≥95%

LP096291	DSPE-PEG-Man			≥95%

LP096207	DSPE-PEG-MTX			≥95%

LP096006	DSPE-PEG-N3			≥95%

LP096202	DSPE-PEG-NBD			≥95%

LP096252	DSPE-PEG-NTA-NI			≥95%

LP096002	DSPE-PEG-OH			≥95%

LP096035	DSPE-PEG-OPSS			≥95%

LP096216	DSPE-PEG-Progestrone			≥95%

LP096074	DSPE-PEG-RGD			≥95%

LP096023	DSPE-PEG-SC			≥95%

LP096024	DSPE-PEG-SCM			≥95%

LP096027	DSPE-PEG-SG			≥95%

LP096003	DSPE-PEG-SH			≥95%

LP096020	DSPE-PEG-Silane			≥95%

LP096105	DSPE-PEG-SP2-AA			≥95%

LP096028	DSPE-PEG-SS			≥95%

LP096175	DSPE-PEG-TPP			≥95%

LP341057	DSPE-SS-PEG-FA

LP099017	DLPE-PEG-COOH			≥95%

LP099022	DLPE-PEG-Mal			≥95%

LP099005	DLPE-PEG-NH2			≥95%

LP099023	DLPE-PEG-SC			≥95%

LP097041	DMPE-PEG-Biotin			≥95%

LP097017	DMPE-PEG-COOH			≥95%

LP097167	DMPE-PEG-CY3			≥95%

LP097048	DMPE-PEG-DBCO			≥95%

LP097022	DMPE-PEG-Mal			≥95%

LP097202	DMPE-PEG-NBD			≥95%

LP097005	DMPE-PEG-NH2			≥95%

LP097023	DMPE-PEG-SC			≥95%

LP097020	DMPE-PEG-Silane			≥95%

LP100041	DOPE-PEG-Biotin			≥95%

LP100121	DOPE-PEG-CH2COOH			≥95%

LP100057	DOPE-PEG-FA

LP100022	DOPE-PEG-Mal			≥95%

LP100005	DOPE-PEG-NH2			≥95%

LP100023	DOPE-PEG-SC			≥95%

LP098041	DPPE-PEG-BIOTIN			≥95%

LP098017	DPPE-PEG-COOH			≥95%

LP098022	DPPE-PEG-Mal			≥95%

LP098006	DPPE-PEG-N3			≥95%

LP098005	DPPE-PEG-NH2			≥95%

LP098023	DPPE-PEG-SC			≥95%

LP095041	CLS-PEG-Biotin			≥95%

LP095004	CLS-PEG-CHO			≥95%

LP095095	CLS-PEG-CLS			≥95%

LP095017	CLS-PEG-COOH			≥95%

LP095048	CLS-PEG-DBCO			≥95%

LP095057	CLS-PEG-FA

LP095044	CLS-PEG-FITC			≥95%

LP095022	CLS-PEG-Mal			≥95%

LP095006	CLS-PEG-N3			≥95%

LP095202	CLS-PEG-NBD			≥95%

LP095005	CLS-PEG-NH2			≥95%

LP095002	CLS-PEG-OH			≥95%

LP095013	CLS-PEG-SA			≥95%

LP095023	CLS-PEG-SC			≥95%

LP095024	CLS-PEG-SCM			≥95%

LP095027	CLS-PEG-SG			≥95%

LP095003	CLS-PEG-SH			≥95%

LP095020	CLS-PEG-Silane			≥95%

LP095028	CLS-PEG-SS			≥95%

LP080096	CY7-PEG-DSPE			≥95%

LP072226	Galactose-PEG-Palmitic acid			≥95%

LP226017	Palmitic acid-PEG-COOH			≥95%

LP226022	Palmitic acid-PEG-Mal			≥95%

LP226005	Palmitic acid-PEG-NH2			≥95%

LP226023	Palmitic acid-PEG-SC			≥95%

FL045096	RB-PEG-DSPE			≥95%

LP101004	STA-PEG-CHO			≥95%

LP101017	STA-PEG-COOH			≥95%

LP101057	STA-PEG-FA

LP101044	STA-PEG-FITC			≥95%

LP101022	STA-PEG-Mal			≥95%

LP101202	STA-PEG-NBD			≥95%

LP101005	STA-PEG-NH2			≥95%

LP101002	STA-PEG-OH			≥95%

LP101023	STA-PEG-SC			≥95%

LP101003	STA-PEG-SH			≥95%

A44095	4-ARMPEG-CLS			≥95%