Monodisperse (Discrete) PEG Linkers for Drug Development

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Monodispersed PEGs

Monodisperse (Discrete) PEG Linkers are pure compounds with precise PEG units and a single molecular weight. Monodispersed PEGs from Biopharma PEG maintain excellent water solubility, providing PEGylated drugs with the same advantages of reduced aggregation and immunogenicity, as well as increased hydrodynamic volume.

Monodispersed PEGs have been applied in many fields, including medical research, drug-release, nanotechnology, etc. And they have become very beneficial in drug design and development, specifically in the antibody-drug conjugates and small-molecule drugs.

Why Monodispersed PEGs Can Help?
• Improved pharmacokinetics: Enhanced solubility; improved stability.
• Increased circulation time: Decreased amount of drug required; decreased dosing frequency; reduced renal clearance increases circulation time.
• Decreased toxicity: Improved safety profile; reduced immunogenicity; reduced antigenicity; reduced proteolysis.

Biopharma PEG provides high-purity monodisperse PEG linkers with an extensive variety of functional groups from gram to kilogram batch size or large commercial scale in both non-GMP and GMP grade, such as mPEG36-NH2, N3-PEG3-SPA, NH2-PEG3-OH, and NH2-PEG24-COOH etc.

References:
1. Kinbara, K. Monodisperse engineered PEGs for bio-related applications. Polym J 50, 689–697 (2018). https://doi.org/10.1038/s41428-018-0074-2

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