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To learn about the applications of high-quality Biochempeg PEGs for drug delivery, PEGylation of therapeutics, medical devices, hydrogels, biomaterials, 3D printing, diagnostics, and others, we invite you to review the select reference publications below or visit this link and each PEG product page.

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Radioactive organic semiconducting polymer nanoparticles for multimodal cancer theranostics
Ningyue Yu, Linzhou Zhao, Danling Cheng, Mengbin Ding, Yan Lyu, Jinhua Zhao, Jingchao Li
Published date: August 2022, https://doi.org/10.1016/j.jcis.2022.03.107
Enhanced effect of autologous EVs delivering paclitaxel in pancreatic cancer
Hasan Al Faruque, Eun-Sook Choi, Jung-HeeKim, Eunjoo Kim
Published date: July 2022, https://doi.org/10.1016/j.jconrel.2022.05.012
Characterization of breast cancer antibody (anti-HER-II) conjugated on PEGylated gold nanourchin for active targeting
Mohammad E. Khosroshahi, Yesha Patel & Roxana Chabok
Published date: 02 June 2022, https://doi.org/10.1007/s13404-022-00316-w

Functionalized nanoparticles for brain targeted BDNF gene therapy to rescue Alzheimer's disease pathology in transgenic mouse model
Sanjay Arora, Takahisa Kanekiyo, Jagdish Singh
Keywords: BDNF, Liposomes, Blood brain barrier, Gene therapy, Alzheimer's disease
Published Date: 31 May 2022,
Fluorescence-Shadowing Nanoparticle Clusters for Real-Time Monitoring of Tumor Progression
Oanh-Vu Pham-Nguyen, JiUn Shin, Yeonju Park, Sila Jin, Song Rae Kim, Young Mee Jung, and Hyuk Sang Yoo
Published Date: April 22, 2022,
Polyethylene terephthalate textile heart valve: How poly(ethylene glycol) grafting limits fibrosis
Amna Amri, Pascale Chevallier, Andrée-Anne Guay-Bégin, Ibrahim Bilem, Guillaume Gauvin, Houshang Alamdari, Frédéric Heim, Gaétan Laroche
Published data: 14 April 2022,
PEG-NH2 molecules (M w = 1000 g/mol)

Modulation Technique of Localized Surface Plasmon Resonance of Palladium Nanospheres by Coating with Titanium Dioxide Shell for Application to Photothermal Therapy Agent
Yutaro Hayakawa, Masato Furuya, Hironobu Tahara, Yasuhiro Kosuge, Tsuyoshi Kimura, Kosuke Sugawa, Joe Otsuk
Published date: 31 Mar 2022,

Dual irradiation-triggered anticancer therapeutics composed of polydopamine-coated gold nanoparticles
Mi So Lee, Yeonju Park, Song Rae Kim, Young Mee Jung, Hyuk Sang Yoo
Published date: 28 Mar 2022,
Methoxypolyethylene glycol thiol (mPEG-SH)
Specialty molecules from plants and in vitro cultures as new drugs: regulatory considerations from flask to patient
Jinhui Dou, Pamela Weathers
Published date: 23 March 2022,

Bio-organism detection using microsphere resonators in fluidics
B. J. Demory, L. T. Echeveria, S. Gilmore, C. Tolfa, S. Harrison, G. Chavez, P. K. Singh, A. S. P. Chang, T. Bond
Published date: 4 Mar 2022, 

Evaporation Patterns of Dextran–Poly(Ethylene Glycol) Droplets with Changes in Wettability and Compatibility
Chiho Watanabe, Miho Yanagisawa
Published date: 4 March 2022,
Rhodamine B-labeled PEG (RB-PEG) (molecular weight of 5000, 5 k)
A Three-Dimensional Printable Hydrogel Formulation for the Local Delivery of Therapeutic Nanoparticles to Cervical Cancer
Mariia Kiseleva, Mahmoud M. Omar, Élodie Boisselier, Svetlana V. Selivanova, and Marc-André Fortin
Published date: 28 Feb 2022,
Thiol-polyethylene glycol-NHS (HS-PEG-NHS, 1000 Da, ≥95.0%)
Nimotuzumab Iodine-131 Conjugated with Mnfe2o4 for Potential Dual-Modality (Mri/Spect) Imaging Nanoprobe
Amal Rezka Putra, Yoki Yulizar, Rien Ritawidya, Dewangga Oky Bagus Apriandanu, Sumandi Juliyanto, Ahsanal Fikri, Rizki Marcony Surya
Published date: 16 Feb 2022,

Understanding the Biomolecular Coronas of High-Density Lipoproteins on PEGylated Au Nanoparticles: Implication for Lipid Corona Formation in the Blood
Soo Hyun KimSoo Hyun Kim
Department of Chemistry, Gachon University, Seongnam, Gyeonggi 13120, Republic of Korea
Soo Hyun Kim, Chaewon Lee, Gwi Ju Jang, Sunghoon Yoo, Seunghyun Lee, and Sang Yun Han
Published date: 11 Feb 2022,
Methoxy polyethylene glycol thiol (m-PEG-SH, ≥95%, 5 kDa)

Photopolymerized Features via Beam Pen Lithography as a Novel Tool for the Generation of Large Area Protein Micropatterns
Xinpeng Zhang,Shaowei Ding,Jared Magoline,Andrey Ivankin,Chad A. Mirkin
Published Date:: 04 Feb 2022, https://doi.org/10.1002/smll.202105998
SH-PEG-Biotin (MW 400)
Zebrafish (Danio rerio) larva as an in vivo vertebrate model to study renal function
Jan Stephan Bolten, Anna Pratsinis, Claudio Luca Alter, Gert Fricker, and Jörg Huwyler
Published Date: 17 Jan 2022, https://doi.org/10.1152/ajprenal.00375.2021
Assessment of iron nanoparticle distribution in mouse models using ultrashort-echo-time MRI
Andreas Boss, Laura Heeb, Divya Vats, Fabian H. L. Starsich, Alice Balfourier, Inge K. Herrmann, Anurag Gupta
Published Date: 07 Jan 2022, https://doi.org/10.1002/nbm.4690
Direct-Ink Write 3D Printing Multistimuli-Responsive Hydrogels and Post-Functionalization Via Disulfide Exchange
Christopher R. Fellin and Alshakim Nelson
Published Date: 06 Jan 2022, https://doi.org/10.1021/acsapm.1c01538

Role of Negatively Charged Lipids Achieving Rapid Accumulation of Water-Soluble Molecules and Macromolecules into Cell-Sized Liposomes against a Concentration Gradient
Hironori Sugiyama, Toshihisa Osaki, Shoji Takeuchi, and Taro Toyota
Published Date: 30 Dec 2021, https://doi.org/10.1021/acs.langmuir.1c02103
mPEG-fluorescein 750 and mPEG-fluorescein 40K
Membrane-Based In-Gel Loop-Mediated Isothermal Amplification (mgLAMP) System for SARS-CoV-2 Quantification in Environmental Waters
Yanzhe Zhu, Xunyi Wu, Alan Gu, Leopold Dobelle, Clément A. Cid, Jing Li, and Michael R. Hoffmann
Published Date: 30 Dec 2021, https://doi.org/10.1021/acs.est.1c04623
four-arm PEG acrylate and thiol-PEG-thiol
Blood-brain Barrier Crossing using Magnetic Stimulated Nanoparticles
Jingfan Chen, Muzhaozi Yuan, Caitlin A Madison, Shoshana Eitan, Ya Wang
Published Date: 24 Dec 2021, https://doi.org/10.1101/2021.12.23.472846
Drag force of polyethyleneglycol in flows of polymer solutions measured using a scanning probe microscope
Ruri Hidema, Ken-ya Fujito  and  Hiroshi Suzuki
Published Date: 02 Dec 2021, https://doi.org/10.1039/D1SM01305J
mPEG–SH 40k

Targeting neurons in the tumor microenvironment with bupivacaine nanoparticles reduces breast cancer progression and metastases
Published date: 6 Oct 2021, DOI: 10.1126/sciadv.abj5435

A glycan-based plasmonic sensor for prostate cancer diagnosis
Mathieu Lamarre , Thomas Tremblay , Marc-Antoine Bansept , Karine Robitaille , V Fradet , Denis Giguère and Denis Boudreau
Published date: 1 Oct 2021, 

Market Trend and Current Status of the Research and Development of Antibody-Drug Conjugates
Kwon, Sun-Il (Department of Biomedical Laboratory Science, Deagu Health Science University)
Published date: 30 Sep 2021, https://doi.org/10.15616/BSL.2021.27.3.121

Optimizing Surface Modification of Silicon Nanowire Field-Effect Transistors by Polyethylene Glycol for MicroRNA Detection
Cao-An Vu, Hsin-Ying Lai, Chia-Yu Chang, Hardy Wai-Hong Chan, Wen-Yih Chen
Published date: 28 Sep 2021,
silane-PEG-NH2, silane-PEG-OH
Functionalized silica nanoplatform as a bimodal contrast agent for MRI and optical imaging
Sarah Garifo, Dimitri Stanicki, Sébastien Boutry, Lionel Larbanoix, Indiana Ternad, Robert N. Muller and Sophie Laurent
Published date: 20 Sep 2021,
Perpendicular alignment of the phase-separated boundary in adhered polymer droplets
Eriko Shinohara, Chiho Watanabe, Miho Yanagisawa
Published date: 17 Sep 2021,
Digital Simulation Assessments of the Sensitivity of Quantitative MRI for Detection of an Iron Oxide Nanoparticle Brain MRI Contrast Agent
Joong Kim, Wen-Tung Wang, Andrew Knutsen, David Brody
Published date: 13 Aug 2021,
Effects of site-directed PEGylation on L-asparaginase thermostability
Cunha, Jheniffer Rabelo
Published date: 11 Aug 2021,

The impact of locally-delivered tacrolimus-releasing microspheres and polyethylene glycol-based islet surface modification on xenogeneic islet survival
Tiep Tien Nguyen, Cao Dai Phung, Jong Oh Kima
, Chul Soon Yong, Jae-Ryong Kim, Simmyung Yook, Jee-Heon Jeong
Published date: 10 August 2021,

The Role of Common Solvents against Pseudomonas aeruginosa-Induced Pathogenicity in a Murine Burn Site Infection Model
Vijay K. Singh, Marianna Almpani, Laurence G. Rahme
Published date: 04 August 2021,
The Sustainability of Energy Conversion Inhibition for Tumor Ferroptosis Therapy and Chemotherapy
Wei Jiang, Xingyu Luo, Lulu Wei, Shanmei Yuan, Jianfeng Cai, Xiqun Jiang, Yong Hu
Published date: 04 August 2021,
An adventitial painting modality of local drug delivery to abate intimal hyperplasia
Takuro Shirasu, Nisakorn Yodsanit, Xiujie Xie, Yi Zhao, Yuyuan Wang, Ruosen Xie, Yitao Huang, Bowen Wang, Go Urabe, Shaoqin Gong, Lian-Wang Guo, K Craig Kent
Published date: August 2021,
Methoxy-PEG-NH 2 (mPEG-NH2 , M n = 5 kDa), NH2-PEG-OH (M n = 5 kDa), maleimide-PEG-NH2 (Mal-PEG-NH2 , M n = 5 kDa), 4-armPEG-NH2 (M n = 10 kDa), and 4-armPEG-NHS(M n = 10 kDa)

O-Linked-N-Acetylglucosaminylation of the RNA-Binding Protein EWS N-Terminal Low Complexity Region Reduces Phase Separation and Enhances Condensate Dynamics
Michael L. Nosella, Maria Tereshchenko, Iva Pritišanac, P. Andrew Chong, Jeffrey A. Toretsky, Hyun O. Lee, and Julie D. Forman-Kay
Published Date:July 25, 2021, https://doi.org/10.1021/jacs.1c04194
Highly Magnetized Encoded Hydrogel Microparticles with Enhanced Rinsing Capabilities for Efficient microRNA Detection
Wookyoung Jang, Jiwoo Kim, Seok Joon Mun, Sun Min Kim and Ki Wan Bong
Published date: 20 July 2021, https://doi.org/10.3390/biomedicines9070848
Thiolated PEG 350

Reversible Hydrogels with Switchable Diffusive Permeability
Paola Nicolella, Daniel Lauxen, Mostafa Ahmadi, Sebastian Seiffert
Published date: 16 July 2021, https://doi.org/10.1002/macp.202100076

Anti-Fn14 Antibody-Conjugated Nanoparticles Display Membrane TWEAK-Like Agonism
Ahmed Aido, Olena Zaitseva, Harald Wajant, Matej Buzgo and Aiva Simaite
Published Date: 13 July 2021, https://doi.org/10.3390/pharmaceutics13071072
mPEG-SH/mPEG-Thiol (5 kDa) and SH-PEG-COOH/Thiol-PEG-Acid (5 kDa)
Reactive oxygen species-responsive dendritic cell-derived exosomes for rheumatoid arthritis
Eun Sook Leea, Jae Hoon Sul, Jung Min Shin, Sol Shin, Jae Ah Lee, Hark Kyun Kim, Yongeun Cho, Hyewon Ko, Soyoung Son, Jeongmi Lee, Sunyoung Park, Dong-Gyu Jo, Jae HyungPark
Published Date: 1 July 2021, https://doi.org/10.1016/j.actbio.2021.04.026
Fluorescein-PEG-amine (Mn = 5000 Da) and DSPE-PEG-FITC (Mn = 5000 Da)

Chelating Agent Functionalized Substrates for the Formation of Thick Films via Electrophoretic Deposition
Sara C. Mills, Natalie E. Starr, Nicholas J. Bohannon, and Jennifer S. Andrew
Published Date: 17 June 2021,
doi: 10.3389/fchem.2021.703528

Epitope-Functionalized Gold Nanoparticles for Rapid and Selective Detection of SARS-CoV-2 IgG Antibodies
Tedrick Thomas Salim Lew, Khin Moh Moh Aung, Sian Yang Ow, Siti Naqiah Amrun, Laura Sutarlie, Lisa F. P. Ng, and Xiaodi Su
Published Date: June 16, 2021, https://doi.org/10.1021/acsnano.1c04091

Antibody-Drug-Conjugate Therapy for Hematological Cancers: Matching Cell Biology with Clinical Benefit
Michael A. Firer, Galia Luboshits
Published date: 24 May 2021,
Stability and Performance Study of Fluorescent Organosilica pH Nanosensors
Gabriel T. Huynh, Edward C. Henderson, Jessica E. Frith, Laurence Meagher, and Simon R. Corrie
Published Date: 19 May 2021, https://doi.org/10.1021/acs.langmuir.1c00936

Gene-Directed Enzyme Prodrug Therapy by Dendrimer-Like Mesoporous Silica Nanoparticles against Tumor Cells
Vicente Candela-Noguera, Gema Vivo-Llorca, Borja Díaz de Greñu, María Alfonso, Elena Aznar, Mar Orzáez, María Dolores Marcos, Félix Sancenón and Ramón Martínez-Máñez
Published date: 14 May 2021,
mPEG-SH 5k

Innate Immune Invisible Ultrasmall Gold Nanoparticles—Framework for Synthesis and Evaluation
Geyunjian Harry Zhu, Mohammad Azharuddin, Rakibul Islam, Hassan Rahmoune, Suryyani Deb, Upasona Kanji, Jyotirmoy Das, Johannes Osterrieth, Parminder Aulakh, Hashi Ibrahim-Hashi, Raghav Manchanda, Per H. Nilsson, Tom Eirik Mollnes, Maitreyee Bhattacharyya, Mohammad M. Islam, Jorma Hinkula, Nigel K. H. Slater, and Hirak K. Patra
Published Date: May 12, 2021, https://doi.org/10.1021/acsami.1c02834

Superparamagnetic iron oxide–gold nanoparticles conjugated with porous coordination cages: Towards controlled drug release for non-invasive neuroregeneration
Muzhaozi Yuan PhD, Tian-Hao Yan BSc, Jialuo Li PhD, Zhifeng Xiao BSc, Yu Fang PhD, Ya Wang PhD, Hong-Cai Zhou PhD, Jean-Philippe Pellois PhD
Published date: 16 April 2021, https://doi.org/10.1016/j.nano.2021.102392
RB-PEG-SH (FL045003-1K)
Entropy-Driven Supramolecular Ring-Opening Polymerization of a Cyclic Hemoglobin Monomer for Constructing a Hemoglobin–PEG Alternating Polymer with Structural Regularity
Takashi Matsuhira and Hiromi Sakai
Published Date: April 15, 2021, https://doi.org/10.1021/acs.biomac.1c00061
PEGylated nanoparticle albumin-bound steroidal ginsenoside derivatives ameliorate SARS-CoV-2-mediated hyper-inflammatory responses
Hee HoPark, Hyelim Kim, Han Sol Lee, Eun U Seo, Ji-Eun Kim, Jee-Hyun Lee, Yong-Hyeon Mun, So-Yeol Yoo, Jiseon An, Mi-YoungYun
Published date: 14 April 2021, https://doi.org/10.1016/j.biomaterials.2021.120827

Phage Digestion of a Bacterial Capsule Imparts Resistance to Two Antibiotic Agents
Cheng-Hung Luo, Ya-Han Hsu, Wen-Jui Wu, Kai-Chih Chang and Chen-Sheng Yeh
Published date: 10 April 2021, https://doi.org/10.3390/microorganisms9040794

Rapid β-human chorionic gonadotropin detection in urine with electric-double-layer gated field-effect transistor biosensors and a handheld device
Liang-Wen Liao, Po-Hsuan Chen, Shu-Yi Tsai, Adarsh Tripathi, Akhil K. Paulose, Shing-Jyh Chang, and  Yu-Lin Wang
Published date: 05 April 2021, https://doi.org/10.1063/5.0042522

Bombesin-Tethered Reactive Oxygen Species (ROS)-Responsive Nanoparticles for Monomethyl Auristatin F (MMAF) Delivery
Jihoon Kim, Jee Seon Kim, Kyung Hyun Min, Young-Hwa Kim  and Xiaoyuan Chen
Published date: 29 March 2021, https://doi.org/10.3390/bioengineering8040043

High-Sensitivity Permeation Analysis of Ultrasmall Nanoparticles Across the Skin by Positron Emission Tomography
Mahmoud M. Omar, Myriam Laprise-Pelletier, Pascale Chevallier, Ludovic Tuduri, and Marc-André Fortin
Published Date: March 10, 2021, https://doi.org/10.1021/acs.bioconjchem.1c00017

Multi-responsive hydrogel cross-linked synthesized spiropyran-based hydrophilic cross-linker
Jeong, Hye-Won; Kim, Sang Jin; Heo, Eun-Jin; Shin, Sung Gyu; Han, Sa Ra; Jeong, Jae Hyun
Published date: 28 February 2021, https://doi.org/10.12925/jkocs.2021.38.1.126

A covalently crosslinked bioink for multi-materials drop-on-demand 3D bioprinting of three-dimensional cell cultures
Robert H. Utama, Vincent T. G. Tan, Kristel C. Tjandra, Andrew Sexton, Duyen H. T. Nguyen, Aidan P. O’Mahony, Julio C. C. Ribeiro,  Maria Kavallaris, J. Justin Gooding
Published date: February 18 2021,  https://doi.org/10.1101/2021.02.18.431759
4-arm PEG-maleimide

Improved biomarker quantification of silicon nanowire field-effect transistor immunosensors with signal enhancement by RNA aptamer: Amyloid beta as a case study
Cao-AnVu, Wen-Yih Chen, Yuh-Shyong Yang, Hardy Wai-Hong Chan
Published date: 15 February 2021,  https://doi.org/10.1016/j.snb.2020.129150
Silane-PEG-NH2, 1 K and Silane-PEG-OH, 1 K

Marine sponge-derived/inspired drugs and their applications in drug delivery systems
Avin Ramanjooloo, Raymond J Andersen & Archana Bhaw-Luximon
Published date:10 Feb 2021, https://doi.org/10.4155/fmc-2020-0123

Demonstration of the enhancement of gate bias and ionic strength in electric-double-layer field-effect-transistor biosensors
Chang-Run Wu, Shin-Li Wang, Po-Hsuan Chen, Yu-Lin Wang, Yu-Rong Wang, Jung-Chih Chen
Published date: 1 February 2021, https://doi.org/10.1016/j.snb.2021.129567

Engineering Modular Half-Antibody Conjugated Nanoparticles for Targeting CD44v6-Expressing Cancer Cells
Bianca N. Lourenço, Rúben F. Pereira, Cristina C. Barrias, Claudia Fischbach, Carla Oliveira, Pedro L. Granja
Published date: 23 January 2021, https://doi.org/10.3390/nano11020295
3.4 kD Mal-PEG-NH2

Combination of Aptamer Amplifier and Antigen-Binding Fragment Probe as a Novel Strategy to Improve Detection Limit of Silicon Nanowire Field-Effect Transistor Immunosensors
Cao-An Vu, Pin-Hsien Pan, Yuh-Shyong Yang, Hardy Wai-Hong Chan, Yoichi Kumada and
Wen-Yih Chen 
Published date: 19 January 2021, https://doi.org/10.3390/s21020650
PEG-mSAMs (silane-PEG-NH2 , 1K and silane-PEG-OH, 1K)

Challenges and advancements in the pharmacokinetic enhancement of therapeutic proteins
Farnaz Khodabakhsh, Morteza Salimian, Mohammad Hossein Hedayati, Reza Ahangari Cohan, Dariush Norouzian
Published date: 18 Jan 2021, 

Single Step In Situ Detection of Surface Protein and MicroRNA in Clustered Extracellular Vesicles Using Flow Cytometry
Hee Cheol Yang, Won Jong Rhee
Published date: 17 January 2021, https://doi.org/10.3390/jcm10020319

Surface Plasmon-Enhanced Short-Wave Infrared Fluorescence for Detecting Sub-Millimeter-Sized Tumors
Shengnan Huang, Ching-Wei Lin, Jifa Qi, Archana Mahadevan Iyer, Yanpu He, Yingzhong Li, Neelkanth M. Bardhan, Darrell J. Irvine, Paula T. Hammond, Angela M. Belcher
Published date: 14 January 2021, https://doi.org/10.1002/adma.202006057
folic acid–PEG5000–NHS (FA-PEG-NHS)
Engineered ionizable lipid nanoparticles for targeted delivery of RNA therapeutics into different types of cells in the liver
M. Kim, M. Jeong, S. Hur, Y. Cho2, J. Park, H. Jung1, Y. Seo, H. A. Woo, K. T. Nam, K. Lee
Published date: 11 January 2021, DOI: 10.1126/sciadv.abf4398
DSPE-PEG-mannose and DSPE-PEG-galactose

A Carbodiimide Coupling Approach for PEGylating GelMA and Further Tuning GelMA Composite Properties
Patricia Comeau, Thomas Willett
Published date: 07 December 2020, https://doi.org/10.1002/mame.202000604

Transferrin-Conjugated pH-Responsive γ-Cyclodextrin Nanoparticles for Antitumoral Topotecan Delivery
Seonyoung Yoon, Yoonyoung Kim, Yu Seok Youn, Kyung Taek Oh, Dongin Kim and Eun Seong Lee
Keywords: pH-Responsive γ-cyclodextrin, tumor-targeted drug delivery system, transferrin, topotecan
Published date: 18 November 2020, https://doi.org/10.3390/pharmaceutics12111109

Highly Red Light-Emitting Erbium- and Lutetium-Doped Core-Shell Upconverting Nanoparticles Surface-Modified with PEG-Folic Acid/TCPP for Suppressing Cervical Cancer HeLa Cells
Kyungseop Lim, Hwang Kyung Kim, Xuan Thien Le, Nguyen Thi Nguyen, Eun Seong Lee, Kyung Taek Oh, Han-Gon Choi, Yu Seok Youn
Keywords: upconverting nanoparticles, photodynamic therapy, tetrakis(4-carboxy-phenyl)porphyrin, near infrared, cancer, hypoxia
Published date: 17 November 2020, https://doi.org/10.3390/pharmaceutics12111102

Specific cellular internalization and pH-responsive behavior of doxorubicin loaded PLGA-PEG nanoparticles targeted with anti EGFRvIII antibody
Neda Eivazi, Reza Rahmani, Maliheh Paknejad
Keywords: PLGA-PEG-COOH, Doxorubicin, EGFRvIII, Monoclonal antibody, Cell cycle, Apoptosis, pH responsive
Publication Date: 15 November 2020, https://doi.org/10.1016/j.lfs.2020.118361

Improved biomarker quantification of silicon nanowire field-effect transistor immunosensors with signal enhancement by RNA aptamer: Amyloid beta as a case study
Cao-An Vu, Wen-Yih Chen, Yuh-Shyong Yang, Hardy Wai-Hong Chan
Keywords: Silicon nanowire field-effect transistor immunosensor, Aptamer, Alzheimer disease, Amyloid beta 1-42, Mixed self-assembled monolayer, Signal enhancement
Publication Date: 13 November 2020, https://doi.org/10.1016/j.snb.2020.129150

A Reliable BioFET Immunosensor for Detection of p53 Tumour Suppressor in Physiological-Like Environment
Chiara Baldacchini, Antonino Francesco Montanarella, Luca Francioso, Maria Assunta Signore, Salvatore Cannistraro and Anna Rita Bizzarri 
Keywords: p53, EGFET, immunosensors, BioFET
Published Date: 8 November 2020, https://doi.org/10.3390/s20216364


The lipid platform increases the activity of STING agonists to synergize checkpoint blockade therapy against melanoma
Kesang Li,  Yingyi Ye, Liqin Liu, Qian Sha, Xiaolu Wang, Ting Jiao, Li Zhangac and Jinyan Wang
Publication Date: 04 Nov 2020, https://doi.org/10.1039/D0BM00870B

Conjugation of biphenyl groups with poly(ethylene glycol) to enhance inhibitory effects on the PD-1/PD-L1 immune checkpoint interaction
Eunhye Kim , Boyang Ning , Masuki Kawamoto , Hideyuki Miyatake , Eiry Kobatake , Yoshihiro Ito and Jun Akimoto
Publication Date: September 30, 2020, https://doi.org/10.1039/D0TB01729A
PEG monomethyl ether amine

In vivo Glioblastoma Therapy Using Targeted Liposomal Cisplatin
Ashrafzadeh MS, Akbarzadeh A, Heydarinasab A, Ardjmand M
Keywords: liposome, targeted drug delivery, brain tumor, blood brain barrier, cisplatin
Publication Date: September 23, 2020, https://doi.org/10.2147/IJN.S255902
DSPE-PEG(2000) Maleimide

Controlling the Biological Fate of Micellar Nanoparticles: Balancing Stealth and Targeting
Amal J. Sivaram, Andri Wardiana, Sheilajen Alcantara, Stefan E. Sonderegger, Nicholas L. Fletcher, Zachary H. Houston, Christopher B. Howard, Stephen M. Mahler, Cameron Alexander, Stephen J. Kent, Craig A. Bell, and Kristofer J. Thurecht*
Keywords: single-chain variable fragment, poly(ethylene glycol), antibody density, micellar nanoparticles, tumor targeting
Publication Date: September 16, 2020, https://doi.org/10.1021/acsnano.0c06033

Hypoxia-Responsive, Polymeric Nanocarriers for Targeted Drug Delivery to Estrogen Receptor-Positive Breast Cancer Cell Spheroids
Babak Mamnoon, Li Feng, Jamie Froberg, Yongki Choi, Venkatachalem Sathish, and Sanku Mallik*
Keywords: hypoxia, polymersomes, estrogen receptor, breast cancer, targeted drug delivery
Publication Date: September 14, 2020, https://doi.org/10.1021/acs.molpharmaceut.0c00754
mPEG-NH2 (MW: 2000)

An in vitro DNA Sensor-based Assay to Measure Receptor-specific Adhesion Forces of Eukaryotic Cells and Pathogens                                  
Maurizio Wack, Maurizio Wack, Tina Wiegand, Friedrich Frischknecht, E. Ada Cavalcanti-Adam
Keywords: Molecular force sensor, DNA-hairpin, Biomimetic surface, Receptor-mediated forces, Molecular tension fluorescence microscopy, Plasmodium, Sporozoite
Publication Date: September 05, 2020, https://doi.org/10.21769/BioProtoc.3733

In Vitro Characteristics of Glioma Cells Targeting by OX26-modified Liposomal Cisplatin
Ashrafzadeh, Maryam S.; Heydarinasab, Amir; Akbarzadeh, Azim; Ardjmand, Mehdi
Keywords: Brain tumor; OX26 monoclonal antibody; cisplatin; glioma cells; immunoliposome; transferrin receptor
Publication Date: September 01, 2020, https://doi.org/10.2174/1570180817999200330165213
DSPE-PEG(2000) Maleimide

Design and validation of liposomal ApoE2 gene delivery system to evade blood-brain barrier for effective treatment of Alzheimer’s disease
Sanjay Arora, Buddhadev Layek, and Jagdish Singh
Publication Date: August 11, 2020, https://doi.org/10.1021/acs.molpharmaceut.0c00461

Multicomponent Alginate‐Derived Hydrogel Microspheres Presenting Hybrid Ionic‐Covalent Network and Drug Eluting Properties
Luca Szabó, François Noverraz , Sandrine Gerber
Publication Date: 30 July 2020, https://doi.org/10.1002/hlca.202000115
Keywords: alginate, microspheres, ketoprofen, controlled drug release, cross reactive polymers, multifunctional hydrogel

Enzyme-responsive polymeric micelles of cabazitaxel for prostate cancer targeted therapy
Ashutosh Barve, Akshay Jain, Hao Liu, Zhen Zhao, Kun Cheng
Publication Date: 18 June 2020, https://doi.org/10.1016/j.actbio.2020.06.019
Keywords: Cabazitaxel, DUPA, Micelle, Cholesterol, Enzyme-responsive, Prostate cancer

Development of Metal Chelators and Metal Chelating Polymers for Mass Cytometry and Positron Emission Tomography
Cho, Hyungjun
Publication Date: Jun-2020http://hdl.handle.net/1807/101250
Keywords: Antibody conjugation; Mass Cytometry; Metal chelator; Polymer; Positron emission tomography; Zirconium
sulfate-PEG5-carboxylic acid

Targeting the tumor core: hypoxia-responsive nanoparticles for delivery of chemotherapy to pancreatic tumors
Matthew I Confeld, Babak Mamnoon, Li Feng, Heather Jensen-Smith, Priyanka Ray, Jamie Froberg, Jiha Kim, Michael A. Hollingsworth, Mohiuddin Quadir, Yongki Choi, and Sanku Mallik
Publication Date:June 10, 2020, https://doi.org/10.1021/acs.molpharmaceut.0c00247
Keywords: polymersomes, tumor-penetrating, hypoxia-responsive, pancreatic cancer, nanoparticles
Polymers for the synthesis of diblock copolymers were purchased from Biochempeg.

Non-invasive preclinical evaluation of targeted nanoparticles for the delivery of curcumin in treating pancreatic cancer
Prabhuraj R S, Arijit Mal, Snehal K. Valvi, Rohit Srivastav, Abhijit De, and Rajdip Bandyopadhyaya
Publication Date: June 9, 2020, https://pubs.acs.org/doi/10.1021/acsabm.0c00515
Keywords: mesoporous silica, curcumin, pancreatic cancer, PEG, tumor

Control of adhesive ligand density for modulation of nucleus pulposus cell phenotype
Marcos N.Barcellona, Julie E.Speer , Bailey V.Fearing, Liufang Jing, Amit Pathak, Munish C.Gupta, Jacob M.Buchowski, Michael Kelly, Lori A.Setton
Publication Date: August 2020, https://doi.org/10.1016/j.biomaterials.2020.120057
Keywords: Nucleus pulposus;  Intervertebral disc;  Substrate stiffness; Ligand presentation; Laminin-mimetic peptides

Selection of superior targeting ligands using PEGylated PLGA nanoparticles for delivery of curcumin in the treatment of triple-negative breast cancer cells
R.S. Prabhuraj, Kartik Bomb, Rohit Srivastava, Rajdip Bandyopadhyaya
Publication Date: Volume 57, June 2020, 101722, https://doi.org/10.1016/j.jddst.2020.101722
Keywords: PLGA, Curcumin, PEG, Targeted drug delivery, Breast cancer
NH2-PEG-NH2 MW 2000

An Insight Into the Role of Riboflavin Ligand in the Self-Assembly of Poly(lactic-Co-Glycolic Acid)-Based Nanoparticles - A Molecular Simulation and Experimental Approach
Sima Rezvantalab , Mostafa Keshavarz Moraveji , Mohammad Khedri , Reza Maleki 
Publication Date: 2020 May 27. doi: 10.1039/d0sm00203h.

LHRH-conjugated, PEGylated, poly-lactide-co-glycolide nanocapsules for targeted delivery of combinational, chemotherapeutic drugs Docetaxel and Quercetin
Ajinkya A.Shitole, Neeti Sharma, Prabhanjan Giram, Anand Khandwekar, Meghna Baruah, Baijayantimala Garnaik, Santosh Koratkar
Publication Date: 1 May 2020, https://doi.org/10.1016/j.msec.2020.111035
Keywords: Anticancer, Active targeting, EPR effect, Hydrophobic, Controlled release, Prostate
NH 2 -PEG-COOH, Mw- 3400 Da

GLUT-1 an effective target to deliver BDNF gene across blood brain barrier
Sanjay Arora, Divya Sharma, Jagdish Singh
Publication Date: April 30, 2020, American Chemical Society, https://doi.org/10.1021/acschemneuro.0c00076
Keywords: Alzheimer’s disease, liposomes, gene delivery, blood brain barrier, glucose transporter, brain-derived neurotrophic factor

Polycationic gold nanorods as multipurpose in vitro microtubule markers
Viktoria Wedler, Fabian Strauß, Swathi Sudhakar, Gero Lutz Hermsdorf, York-Dieter Stierhof, Erik Schäffer
Publication Date: April 27, 2020 https://doi.org/10.1101/2020.04.25.061127
rhodamine 3.4 k PEG thiol 

Inhibition of Wnt signaling by Frizzled7 antibody-coated nanoshells sensitizes triple-negative breast cancer cells to the autophagy regulator chloroquine
Jianxin Wang, Megan N. Dang & Emily S. Day
Publication Date: 25 April 2020, Nano Research (2020) https://doi.org/10.1007/s12274-020-2795-8
Keywords: nanomedicine, nanoparticles, combination therapy, antibody delivery, cancer stem cells

Enhanced antimicrobial activity of silver nanoparticles conjugated with synthetic peptide by click chemistry
Miguel Gakiya-Teruya, Luis Palomino-Marcelo, Scott Pierce, Alfredo M. Angeles-Boza, Vijay Krishna & Juan Carlos F. Rodriguez-Reyes
Publication Date: 15 April 2020, Journal of Nanoparticle Research volume 22, Article number: 90 (2020) 
Keywords: Click chemistry, Silver nanoparticles, Synthetic peptide, ATCUN, Escherichia coli, Antimicrobial activity, Environmental and health effects

Simple Single-Legged DNA Walkers at Diffusion-Limited Nanointerfaces of Gold Nanoparticles Driven by a DNA Circuit Mechanism
Motoi Oishi* and Kosuke Saito
Publication Date: February 13, 2020, https://doi.org/10.1021/acsnano.9b09581
Keywords: DNA circuit, DNA walker, gold nanoparticle, nanointerface, toehold-mediated DNA displacement reaction

Efficient targeted degradation via reversible and irreversible covalent PROTACs
Ronen Gabizon, Amit Shraga, Paul Gehrtz, Ella Livnah, Neta Gurwicz, Liat Avram, Tamar Unger, Shira Albeck, Ziv Shulman, Nir London
Submitted IN chemrxivon 02.01.2020,  and posted on 08.01.2020 Read More>>
Keyword: PROTACs, reversible covalent, cyanoacrylamides, BTK, targeted degradation
Polyethylene glycol (azide-NHS ester)

Forces during cellular uptake of viruses and nanoparticles at the ventral side
Tina Wiegand,  Marta Fratini, Felix Frey, Klaus Yserentant, Yang Liu, Eva Weber, Kornelia Galior, Julia Ohmes, Felix Braun, Dirk-Peter Herten, Steeve Boulant, Ulrich S. Schwarz, Khalid Salaita, E. Ada Cavalcanti-Adam & Joachim P. Spatz
Nature Communications volume 11, Article number: 32 (2020)  Read More>>
Keyword: Biophysical methods, Endocytosis, Integrins, Nanoparticles, Nanoscale biophysics
SH-PEG-alkynelipoic acid-PEG-NH2

An all-aqueous approach for physical immobilization of PEG-lipid microgels on organoid surfaces
M.Birgul Akolpoglu, Yasemin Inceoglu, Seda Kizilel
Colloids and Surfaces B: Biointerfaces Volume 186, February 2020, 110708  Read More>>
Keyword: Water-in-water emulsion, Microgel, PEG-lipid, Organoid, Islet

Engineering Helical Modular Polypeptide-Based Hydrogels as Synthetic Extracellular Matrices for Cell Culture
Hongkun He, Marianna Sofman, Alex J-S Wang, Caroline C. Ahrens, Wade Wang, Linda G. Griffith, Paula T. Hammond
Biomacromolecules 2019  Read More>>
Cyanine5-labeled PEG-SH (Cy5-PEG-SH, 1 kDa)

Electrostatically Driven Encapsulation of Hydrophilic, Non-Conformational Peptide Epitopes into Liposomes
Ehsan Suleiman, Dominik Damm, Mirjam Batzoni, Vladimir Temchura, Andreas Wagner, Klaus Überla, Karola Vorauer-Uhl 
Pharmaceutics 2019, 11(11), 619; Read More>>
Keyword: electrostatic interactions; encapsulation; encapsulation efficiency; hydrophilic peptides; in situ binding; liposomes; microfluidics; peptides; peptide-membrane interaction; vaccines

Whole-Eye Perfusion Model for Screening of the Ocular Formulations via Confocal Laser Scanning Microscopy
Shallu Kutlehria, Arvind Bagde, Nilkumar Patel, Mandip Singh
AAPS PharmSciTech October 2019, 20:307  Read More>>
Keyword: perfusion model, micelles, confocal, ocular, coumarin-6

Targeted delivery of doxorubicin for the treatment of bone metastasis from breast cancer using alendronate-functionalized graphene oxide nanosheets
Tung Thanh Phama, Hanh Thuy Nguyen, Cao Dai Phung, Shiva Pathak, Shobha Regmi, Dong-Ho Ha, Jong Oh Kim, Chul Soon Yong, Sang Kyoon Kim, Ji-Eun Choi, Simmyung Yook, Jun-Beom Park, Jee-Heon Jeong
Journal of Industrial and Engineering Chemistry Volume 76, 25 August 2019, Pages 310-317  Read More>>
Keyword: Bone metastasis, Graphene oxides, Alendronate, Targeted delivery

Development and screening of brain-targeted lipid-based nanoparticles with enhanced cell penetration and gene delivery properties
Bruna dos Santos Rodrigues, Sushant Lakkadwala, Takahisa Kanekiyo, and Jagdish Singh
Int J Nanomedicine. 2019; 14: 6497–6517. Read More>>
liposomes, transferrin, pVec, QLPVM, TAT, gene delivery

Dual functionalized liposomes for efficient co-delivery of anti-cancer chemotherapeutics for the treatment of glioblastoma
Sushant Lakkadwala, Brunados Santos Rodrigues, ChengwenSun, Jagdish Singh
Journal of Controlled Release Volume 307, 10 August 2019, Pages 247-260 Read More>>
Keyword: Blood-brain barrier, Dual functionalized liposomes, Combination drug therapy, in vitro brain tumor model, Targeted drug delivery, Glioblastoma
NHS-PEG (2000) -DSPE

Functionalized liposomal nanoparticles for efficient gene delivery system to neuronal cell transfection
Bruna dos Santos Rodrigues, Amrita Banerjee, Takahisa Kanekiyo, Jagdish Sing
International Journal of Pharmaceutics  Volume 566, 20 July 2019, Pages 717-730  Read More>>
Keyword: Bifunctional liposome, Transferrin, Penetratin, Gene delivery, Brain targeting

Using microfluidic platforms to develop CNS-targeted polymeric nanoparticles for HIV therapy
Cláudia Martins, Francisca Araújo, Maria João Gomes, Carlos Fernandes, Rute Nunes, Wei Li, Hélder A. Santos, Fernanda Borges, Bruno Sarmento
European Journal of Pharmaceutics and Biopharmaceutics Volume 138, May 2019, Pages 111-124 Read More>>
Keyword: Nanoparticles, Human immunodeficiency virus, Microfluidic production, Targeting, Blood-brain barrier
NH2-PEG-Mal, PEG of 5 kDa  

Thioredoxin Reductase Activity Predicts Gold Nanoparticle Radiosensitization Effect
Sébastien Penninckx, Anne-Catherine Heuskin,Carine Michiels, Stéphane Lucas
Nanomaterials 2019, 9(2), 295;  Read More>>
Keyword: gold nanoparticles; radiosensitization; thioredoxin reductase; radiation; prognosis; biochemical mechanism

PDL-1 Antibody Drug Conjugate for Selective Chemo-Guided Immune Modulation of Cancer
Samaresh Sau, Alex Petrovici, Hashem O. Alsaab, Ketki Bhise,  Arun K. Iyer
Cancers 2019, 11(2), 232; Read More>>
antibody drug conjugate (ADC); PD-L1; tumor spheroid disruption; immune modulation; doxorubicin

Preclinical Evaluation of 111In-labeled PEGylated Maytansine Nimotuzumab Drug Conjugates in EGFR-positive Cancer Models
Siddesh V Hartimath, Elahe Alizadeh, Viswas Raja Solomon, Rufael Chekol, Wendy Bernhard, Wayne Hill, Angel Parada Casaco, Kris Barreto, Clarence Ronald Geyer and Humphrey Fonge
J Nucl Med January 17, 2019 jnumed.118.220095 Read More>>
Animal Imaging, Molecular Imaging, Monoclonal Antibodies, Radiochemistry, Radiopharmaceuticals, SPECT, ADCs, Epidermal Growth Factor Receptor (EGFR), MicroSPECT/CT, Nimotuzumab, pegylated maytansine

Co-delivery of doxorubicin and erlotinib through liposomal nanoparticles for glioblastoma tumor regression using an in vitro brain tumor model
Sushant Lakkadwala, Jagdish Singh
Colloids and Surfaces B: Biointerfaces Volume 173, 1 January 2019, Pages 27-35  Read More>>
Dual-functionalized liposomes, Glioblastoma, In vitro brain tumor model, Co-delivery, Blood brain barrier
NHS-PEG (2000) -DSPE

Development of High-Functionality and -Quality Lipids with RGD Peptide Ligands: Application for PEGylated Liposomes and Analysis of Intratumoral Distribution in a Murine Colon Cancer Model
Tadaharu Suga, Naoya Kato, Masayori Hagimori, Yuki Fuchigami, Naotaka Kuroda, Yukinobu Kodama, Hitoshi Sasaki, Shigeru Kawakam
Mol. Pharmaceutics 2018, 15, 10, 4481-4490  Read More>>
Keyword: targeted liposomal delivery, polyethylene glycol, peptide-mediated targeting, integrin receptor,  tissue clearing
RGD–PEG2000–lipid, PEGylated liposomes 

Gadolinium Metallofullerene-Polypyrrole Nanoparticles for Activatable Dual-Modal Imaging-Guided Photothermal Therapy
Sheng Wang, Zijian Zhou, Guocan Yu, Nan Lu, Yi jing Liu, Yunlu Dai, Xiao Fu, Jing Wang, Xiaoyuan Chen
ACS Appl. Mater. Interfaces 2018, 10, 34, 28382-28389 Read More>>
Keyword: activatable contrast agent, photoacoustic imaging, photothermal therapy, gadolinium metallofullerene, polypyrrole
mPEG5k -NH2

Enzyme–Polymer Conjugates to Enhance Enzyme Shelf Life in a Liquid Detergent Formulation
Sonja Kübelbeck, Jules Mikhael, Harald Keller, Rupert Konradi, Annette Andrieu‐Brunsen,  Grit Baier  
Macromolecular Bioscience 18(7) · June 2018 Read More>>
Keyword: differential scanning calorimetry (DSC), enzymes, modification, stabilization, surfactants
mPEG‐propionaldehyde(5 kDa) , mPEG‐succinimidyl succinate ester

Tacrolimus Loaded PEG-Cholecalciferol Based Micelles for Treatment of Ocular Inflammation
Shallu Kutlehria, Imran Vhora, Arvind Bagde, Nusrat Chowdhury, Gautam Behl, Ketan Patel, Mandip Singh
Pharmaceutical Research June 2018, 35:117 Read More>>
micelles, ocular inflammation, tacrolimus, targeted

Long-Circulating Amphiphilic Doxorubicin for Tumor Mitochondria-Specific Targeting
Jingchao Xi, Meng Li, Benxin Jing, Myunggi An, Chunsong Yu, Cameron B. Pinnock, Yingxi Zhu, Mai T. Lam, Haipeng Liu
ACS Appl. Mater. Interfaces 2018, 10, 50, 43482-43492  Read More>>
Keyword: doxorubicin, mitochondria, amphiphiles, chemotherapy, drug delivery

The role of thioredoxin reductase in gold nanoparticle radiosensitization effects
Sébastien Penninckx, Anne-Catherine Heuskin, Carine Michiels & Stéphane Lucas
NANOMEDICINEVOL. 13, NO. 22  Read More>>
Keyword: biological mechanism, gold nanoparticles, proton irradiation, radiosensitization, thioredoxin reductase

Synthesis, physiochemical characterization, and in vitro antitumor activity of the amide and pH cleavable hydrazone conjugates of γ-tocotrienol isomer of vitamin E with methoxy-poly(ethylene) glycol
AhmedAbu-Fayyad, SamiNazzal
International Journal of Pharmaceutics Volume 529, Issues 1–2, 30 August 2017, Pages 75-86 Read More>>
Keyword: Vitamin E, Tocopherol, Tocotrienol, PEGylation, Acid-degradation, Hydrazone, Drug delivery, Cancer chemotherapy, Nanotechnology
mPEG 2000 succinyl chloride

Hyaluronic Acid Hydrogel Functionalized with Self-Assembled Micelles of Amphiphilic PEGylated Kartogenin for the Treatment of Osteoarthritis
Mi-Lan Kang, Se-Young Jeong, and Gun-Il Im
Tissue Engineering Part AVol. 23, No. 13-14  Read More>>
Keyword: hyaluronic acid, kartogenin, PEGylation, self-assembled micelles, osteoarthritis
NH2-PEG-OH, 2 kDa