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To learn about the applications of high-quality Biochempeg PEGs for drug delivery, PEGylation of therapeutics, medical devices, hydrogels, biomaterials, 3D printing, diagnostics, and others, we invite you to review the select reference publications below or visit this link and each PEG product page.

If you've published research papers with our products, please let us know so your paper can be cited and you can get 20% OFF for your next order.​ Learn More>>

Controlling the Biological Fate of Micellar Nanoparticles: Balancing Stealth and Targeting
Amal J. Sivaram, Andri Wardiana, Sheilajen Alcantara, Stefan E. Sonderegger, Nicholas L. Fletcher, Zachary H. Houston, Christopher B. Howard, Stephen M. Mahler, Cameron Alexander, Stephen J. Kent, Craig A. Bell, and Kristofer J. Thurecht*
Keywords: single-chain variable fragment, poly(ethylene glycol), antibody density, micellar nanoparticles, tumor targeting

Publication Date: September 16, 2020, https://doi.org/10.1021/acsnano.0c06033

An in vitro DNA Sensor-based Assay to Measure Receptor-specific Adhesion Forces of Eukaryotic Cells and Pathogens                                  
Maurizio Wack, Maurizio Wack, Tina Wiegand, Friedrich Frischknecht, E. Ada Cavalcanti-Adam
Keywords: Molecular force sensor, DNA-hairpin, Biomimetic surface, Receptor-mediated forces, Molecular tension fluorescence microscopy, Plasmodium, Sporozoite

Publication Date: September 05, 2020, https://doi.org/10.21769/BioProtoc.3733

Design and validation of liposomal ApoE2 gene delivery system to evade blood-brain barrier for effective treatment of Alzheimer’s disease
Sanjay Arora, Buddhadev Layek, and Jagdish Singh
Publication Date: August 11, 2020, https://doi.org/10.1021/acs.molpharmaceut.0c00461

Multicomponent Alginate‐Derived Hydrogel Microspheres Presenting Hybrid Ionic‐Covalent Network and Drug Eluting Properties
Luca Szabó, François Noverraz , Sandrine Gerber
Publication Date: 30 July 2020, https://doi.org/10.1002/hlca.202000115
Keywords: alginate, microspheres, ketoprofen, controlled drug release, cross reactive polymers, multifunctional hydrogel

Enzyme-responsive polymeric micelles of cabazitaxel for prostate cancer targeted therapy
Ashutosh Barve, Akshay Jain, Hao Liu, Zhen Zhao, Kun Cheng
Publication Date: 18 June 2020, https://doi.org/10.1016/j.actbio.2020.06.019
Keywords: Cabazitaxel, DUPA, Micelle, Cholesterol, Enzyme-responsive, Prostate cancer

Development of Metal Chelators and Metal Chelating Polymers for Mass Cytometry and Positron Emission Tomography
Cho, Hyungjun
Publication Date: Jun-2020http://hdl.handle.net/1807/101250
Keywords: Antibody conjugation; Mass Cytometry; Metal chelator; Polymer; Positron emission tomography; Zirconium
sulfate-PEG5-carboxylic acid

Targeting the tumor core: hypoxia-responsive nanoparticles for delivery of chemotherapy to pancreatic tumors
Matthew I Confeld, Babak Mamnoon, Li Feng, Heather Jensen-Smith, Priyanka Ray, Jamie Froberg, Jiha Kim, Michael A. Hollingsworth, Mohiuddin Quadir, Yongki Choi, and Sanku Mallik
Publication Date:June 10, 2020, https://doi.org/10.1021/acs.molpharmaceut.0c00247
Keywords: polymersomes, tumor-penetrating, hypoxia-responsive, pancreatic cancer, nanoparticles
Polymers for the synthesis of diblock copolymers were purchased from Biochempeg.

Non-invasive preclinical evaluation of targeted nanoparticles for the delivery of curcumin in treating pancreatic cancer
Prabhuraj R S, Arijit Mal, Snehal K. Valvi, Rohit Srivastav, Abhijit De, and Rajdip Bandyopadhyaya
Publication Date: June 9, 2020https://pubs.acs.org/doi/10.1021/acsabm.0c00515
Keywords: mesoporous silica, curcumin, pancreatic cancer, PEG, tumor

Control of adhesive ligand density for modulation of nucleus pulposus cell phenotype
Marcos N.Barcellona, Julie E.Speer , Bailey V.Fearing, Liufang Jing, Amit Pathak, Munish C.Gupta, Jacob M.Buchowski, Michael Kelly, Lori A.Setton
Publication Date: August 2020, https://doi.org/10.1016/j.biomaterials.2020.120057
Keywords: Nucleus pulposus;  Intervertebral disc;  Substrate stiffness; Ligand presentation; Laminin-mimetic peptides

Selection of superior targeting ligands using PEGylated PLGA nanoparticles for delivery of curcumin in the treatment of triple-negative breast cancer cells
R.S. Prabhuraj, Kartik Bomb, Rohit Srivastava, Rajdip Bandyopadhyaya
Publication Date: Volume 57, June 2020, 101722, https://doi.org/10.1016/j.jddst.2020.101722
Keywords: PLGA, Curcumin, PEG, Targeted drug delivery, Breast cancer
NH2-PEG-NH2 MW 2000

An Insight Into the Role of Riboflavin Ligand in the Self-Assembly of Poly(lactic-Co-Glycolic Acid)-Based Nanoparticles - A Molecular Simulation and Experimental Approach
Sima Rezvantalab , Mostafa Keshavarz Moraveji , Mohammad Khedri , Reza Maleki 
Publication Date: 2020 May 27. doi: 10.1039/d0sm00203h.

LHRH-conjugated, PEGylated, poly-lactide-co-glycolide nanocapsules for targeted delivery of combinational, chemotherapeutic drugs Docetaxel and Quercetin
Ajinkya A.Shitole, Neeti Sharma, Prabhanjan Giram, Anand Khandwekar, Meghna Baruah, Baijayantimala Garnaik, Santosh Koratkar
Publication Date: 1 May 2020, https://doi.org/10.1016/j.msec.2020.111035
Keywords: Anticancer, Active targeting, EPR effect, Hydrophobic, Controlled release, Prostate
NH 2 -PEG-COOH, Mw- 3400 Da

GLUT-1 an effective target to deliver BDNF gene across blood brain barrier
Sanjay Arora, Divya Sharma, Jagdish Singh
Publication Date: April 30, 2020, American Chemical Societyhttps://doi.org/10.1021/acschemneuro.0c00076
Keywords: Alzheimer’s disease, liposomes, gene delivery, blood brain barrier, glucose transporter, brain-derived neurotrophic factor

Polycationic gold nanorods as multipurpose in vitro microtubule markers
Viktoria Wedler, Fabian Strauß, Swathi Sudhakar, Gero Lutz Hermsdorf, York-Dieter Stierhof, Erik Schäffer
Publication Date: April 27, 2020 https://doi.org/10.1101/2020.04.25.061127
rhodamine 3.4 k PEG thiol 

Inhibition of Wnt signaling by Frizzled7 antibody-coated nanoshells sensitizes triple-negative breast cancer cells to the autophagy regulator chloroquine
Jianxin Wang, Megan N. Dang & Emily S. Day
Publication Date: 25 April 2020, Nano Research (2020) https://doi.org/10.1007/s12274-020-2795-8
Keywords: nanomedicine, nanoparticles, combination therapy, antibody delivery, cancer stem cells

Enhanced antimicrobial activity of silver nanoparticles conjugated with synthetic peptide by click chemistry
Miguel Gakiya-Teruya, Luis Palomino-Marcelo, Scott Pierce, Alfredo M. Angeles-Boza, Vijay Krishna & Juan Carlos F. Rodriguez-Reyes
Publication Date: 15 April 2020, Journal of Nanoparticle Research volume 22, Article number: 90 (2020) 
Keywords: Click chemistry, Silver nanoparticles, Synthetic peptide, ATCUN, Escherichia coli, Antimicrobial activity, Environmental and health effects

Simple Single-Legged DNA Walkers at Diffusion-Limited Nanointerfaces of Gold Nanoparticles Driven by a DNA Circuit Mechanism
Motoi Oishi* and Kosuke Saito
Publication Date: February 13, 2020, https://doi.org/10.1021/acsnano.9b09581
Keywords: DNA circuit, DNA walker, gold nanoparticle, nanointerface, toehold-mediated DNA displacement reaction

Efficient targeted degradation via reversible and irreversible covalent PROTACs
Ronen Gabizon, Amit Shraga, Paul Gehrtz, Ella Livnah, Neta Gurwicz, Liat Avram, Tamar Unger, Shira Albeck, Ziv Shulman, Nir London
Submitted IN chemrxivon 02.01.2020,  and posted on 08.01.2020 Read More>>
Keyword: PROTACs, reversible covalent, cyanoacrylamides, BTK, targeted degradation
Polyethylene glycol (azide-NHS ester)

Forces during cellular uptake of viruses and nanoparticles at the ventral side
Tina Wiegand,  Marta Fratini, Felix Frey, Klaus Yserentant, Yang Liu, Eva Weber, Kornelia Galior, Julia Ohmes, Felix Braun, Dirk-Peter Herten, Steeve Boulant, Ulrich S. Schwarz, Khalid Salaita, E. Ada Cavalcanti-Adam & Joachim P. Spatz
Nature Communications volume 11, Article number: 32 (2020)  Read More>>
Keyword: Biophysical methods, Endocytosis, Integrins, Nanoparticles, Nanoscale biophysics
SH-PEG-alkynelipoic acid-PEG-NH2

An all-aqueous approach for physical immobilization of PEG-lipid microgels on organoid surfaces
M.Birgul Akolpoglu, Yasemin Inceoglu, Seda Kizilel
Colloids and Surfaces B: Biointerfaces Volume 186, February 2020, 110708  Read More>>
Keyword: Water-in-water emulsion, Microgel, PEG-lipid, Organoid, Islet

Engineering Helical Modular Polypeptide-Based Hydrogels as Synthetic Extracellular Matrices for Cell Culture
Hongkun He, Marianna Sofman, Alex J-S Wang, Caroline C. Ahrens, Wade Wang, Linda G. Griffith, Paula T. Hammond
Biomacromolecules 2019  Read More>>
Cyanine5-labeled PEG-SH (Cy5-PEG-SH, 1 kDa)

Electrostatically Driven Encapsulation of Hydrophilic, Non-Conformational Peptide Epitopes into Liposomes
Ehsan Suleiman, Dominik Damm, Mirjam Batzoni, Vladimir Temchura, Andreas Wagner, Klaus Überla, Karola Vorauer-Uhl 
Pharmaceutics 2019, 11(11), 619; Read More>>
Keyword: electrostatic interactions; encapsulation; encapsulation efficiency; hydrophilic peptides; in situ binding; liposomes; microfluidics; peptides; peptide-membrane interaction; vaccines

Whole-Eye Perfusion Model for Screening of the Ocular Formulations via Confocal Laser Scanning Microscopy
Shallu Kutlehria, Arvind Bagde, Nilkumar Patel, Mandip Singh
AAPS PharmSciTech October 2019, 20:307  Read More>>
Keyword: perfusion model, micelles, confocal, ocular, coumarin-6

Targeted delivery of doxorubicin for the treatment of bone metastasis from breast cancer using alendronate-functionalized graphene oxide nanosheets
Tung Thanh Phama, Hanh Thuy Nguyen, Cao Dai Phung, Shiva Pathak, Shobha Regmi, Dong-Ho Ha, Jong Oh Kim, Chul Soon Yong, Sang Kyoon Kim, Ji-Eun Choi, Simmyung Yook, Jun-Beom Park, Jee-Heon Jeong
Journal of Industrial and Engineering Chemistry Volume 76, 25 August 2019, Pages 310-317  Read More>>
Keyword: Bone metastasis, Graphene oxides, Alendronate, Targeted delivery

Development and screening of brain-targeted lipid-based nanoparticles with enhanced cell penetration and gene delivery properties
Bruna dos Santos Rodrigues, Sushant Lakkadwala, Takahisa Kanekiyo, and Jagdish Singh
Int J Nanomedicine. 2019; 14: 6497–6517. Read More>>
liposomes, transferrin, pVec, QLPVM, TAT, gene delivery

Dual functionalized liposomes for efficient co-delivery of anti-cancer chemotherapeutics for the treatment of glioblastoma
Sushant Lakkadwala, Brunados Santos Rodrigues, ChengwenSun, Jagdish Singh
Journal of Controlled Release Volume 307, 10 August 2019, Pages 247-260 Read More>>
Keyword: Blood-brain barrier, Dual functionalized liposomes, Combination drug therapy, in vitro brain tumor model, Targeted drug delivery, Glioblastoma
NHS-PEG (2000) -DSPE

Functionalized liposomal nanoparticles for efficient gene delivery system to neuronal cell transfection
Bruna dos Santos Rodrigues, Amrita Banerjee, Takahisa Kanekiyo, Jagdish Sing
International Journal of Pharmaceutics  Volume 566, 20 July 2019, Pages 717-730  Read More>>
Keyword: Bifunctional liposome, Transferrin, Penetratin, Gene delivery, Brain targeting

Using microfluidic platforms to develop CNS-targeted polymeric nanoparticles for HIV therapy
Cláudia Martins, Francisca Araújo, Maria João Gomes, Carlos Fernandes, Rute Nunes, Wei Li, Hélder A. Santos, Fernanda Borges, Bruno Sarmento
European Journal of Pharmaceutics and Biopharmaceutics Volume 138, May 2019, Pages 111-124 Read More>>
Keyword: Nanoparticles, Human immunodeficiency virus, Microfluidic production, Targeting, Blood-brain barrier
NH2-PEG-Mal, PEG of 5 kDa  

Thioredoxin Reductase Activity Predicts Gold Nanoparticle Radiosensitization Effect
Sébastien Penninckx, Anne-Catherine Heuskin,Carine Michiels, Stéphane Lucas
Nanomaterials 2019, 9(2), 295;  Read More>>
Keyword: gold nanoparticles; radiosensitization; thioredoxin reductase; radiation; prognosis; biochemical mechanism

PDL-1 Antibody Drug Conjugate for Selective Chemo-Guided Immune Modulation of Cancer
Samaresh Sau, Alex Petrovici, Hashem O. Alsaab, Ketki Bhise,  Arun K. Iyer
Cancers 2019, 11(2), 232; Read More>>
antibody drug conjugate (ADC); PD-L1; tumor spheroid disruption; immune modulation; doxorubicin

Preclinical Evaluation of 111In-labeled PEGylated Maytansine Nimotuzumab Drug Conjugates in EGFR-positive Cancer Models
Siddesh V Hartimath, Elahe Alizadeh, Viswas Raja Solomon, Rufael Chekol, Wendy Bernhard, Wayne Hill, Angel Parada Casaco, Kris Barreto, Clarence Ronald Geyer and Humphrey Fonge
J Nucl Med January 17, 2019 jnumed.118.220095 Read More>>
Animal Imaging, Molecular Imaging, Monoclonal Antibodies, Radiochemistry, Radiopharmaceuticals, SPECT, ADCs, Epidermal Growth Factor Receptor (EGFR), MicroSPECT/CT, Nimotuzumab, pegylated maytansine

Co-delivery of doxorubicin and erlotinib through liposomal nanoparticles for glioblastoma tumor regression using an in vitro brain tumor model
Sushant Lakkadwala, Jagdish Singh
Colloids and Surfaces B: Biointerfaces Volume 173, 1 January 2019, Pages 27-35  Read More>>
Dual-functionalized liposomes, Glioblastoma, In vitro brain tumor model, Co-delivery, Blood brain barrier
NHS-PEG (2000) -DSPE

Development of High-Functionality and -Quality Lipids with RGD Peptide Ligands: Application for PEGylated Liposomes and Analysis of Intratumoral Distribution in a Murine Colon Cancer Model
Tadaharu Suga, Naoya Kato, Masayori Hagimori, Yuki Fuchigami, Naotaka Kuroda, Yukinobu Kodama, Hitoshi Sasaki, Shigeru Kawakam
Mol. Pharmaceutics 2018, 15, 10, 4481-4490  Read More>>
Keyword: targeted liposomal delivery, polyethylene glycol, peptide-mediated targeting, integrin receptor,  tissue clearing
RGD–PEG2000–lipid, PEGylated liposomes 

Gadolinium Metallofullerene-Polypyrrole Nanoparticles for Activatable Dual-Modal Imaging-Guided Photothermal Therapy
Sheng Wang, Zijian Zhou, Guocan Yu, Nan Lu, Yi jing Liu, Yunlu Dai, Xiao Fu, Jing Wang, Xiaoyuan Chen
ACS Appl. Mater. Interfaces 2018, 10, 34, 28382-28389 Read More>>
Keyword: activatable contrast agent, photoacoustic imaging, photothermal therapy, gadolinium metallofullerene, polypyrrole
mPEG5k -NH2

Enzyme–Polymer Conjugates to Enhance Enzyme Shelf Life in a Liquid Detergent Formulation
Sonja Kübelbeck, Jules Mikhael, Harald Keller, Rupert Konradi, Annette Andrieu‐Brunsen,  Grit Baier  
Macromolecular Bioscience 18(7) · June 2018 Read More>>
Keyword: differential scanning calorimetry (DSC), enzymes, modification, stabilization, surfactants
mPEG‐propionaldehyde(5 kDa) , mPEG‐succinimidyl succinate ester

Tacrolimus Loaded PEG-Cholecalciferol Based Micelles for Treatment of Ocular Inflammation
Shallu Kutlehria, Imran Vhora, Arvind Bagde, Nusrat Chowdhury, Gautam Behl, Ketan Patel, Mandip Singh
Pharmaceutical Research June 2018, 35:117 Read More>>
micelles, ocular inflammation, tacrolimus, targeted

Long-Circulating Amphiphilic Doxorubicin for Tumor Mitochondria-Specific Targeting
Jingchao Xi, Meng Li, Benxin Jing, Myunggi An, Chunsong Yu, Cameron B. Pinnock, Yingxi Zhu, Mai T. Lam, Haipeng Liu
ACS Appl. Mater. Interfaces 2018, 10, 50, 43482-43492  Read More>>
Keyword: doxorubicin, mitochondria, amphiphiles, chemotherapy, drug delivery

The role of thioredoxin reductase in gold nanoparticle radiosensitization effects
Sébastien Penninckx, Anne-Catherine Heuskin, Carine Michiels & Stéphane Lucas
NANOMEDICINEVOL. 13, NO. 22  Read More>>
Keyword: biological mechanism, gold nanoparticles, proton irradiation, radiosensitization, thioredoxin reductase

Synthesis, physiochemical characterization, and in vitro antitumor activity of the amide and pH cleavable hydrazone conjugates of γ-tocotrienol isomer of vitamin E with methoxy-poly(ethylene) glycol
AhmedAbu-Fayyad, SamiNazzal
International Journal of Pharmaceutics Volume 529, Issues 1–2, 30 August 2017, Pages 75-86 Read More>>
Keyword: Vitamin E, Tocopherol, Tocotrienol, PEGylation, Acid-degradation, Hydrazone, Drug delivery, Cancer chemotherapy, Nanotechnology
mPEG 2000 succinyl chloride

Hyaluronic Acid Hydrogel Functionalized with Self-Assembled Micelles of Amphiphilic PEGylated Kartogenin for the Treatment of Osteoarthritis
Mi-Lan Kang, Se-Young Jeong, and Gun-Il Im
Tissue Engineering Part AVol. 23, No. 13-14  Read More>>
Keyword: hyaluronic acid, kartogenin, PEGylation, self-assembled micelles, osteoarthritis
NH2-PEG-OH, 2 kDa