Click Chemistry Reagents/Tools, Azide, Alkyne, DBCO, BCN PEG

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Click Chemistry

Click chemistry involves efficient organic reactions of two or more highly functionalized chemical entities under ecologically benign conditions for the synthesis of different heterocycles. Some organic reactions, such as nucleophilic ring-opening reactions, cycloaddition reactions, nucleophilic addition reactions, thiol-ene reactions, and Diels Alder reactions are included in click reactions. These reactions have very important characteristics, i.e. high functional group tolerance, formation of single products, high atomic economy, high yields, no need for column purification, etc.

Due to its biocompatibility, click chemistry is widely used for bioconjugation: the selective joining of small building blocks by rapid and irreversible one-pot reaction under mild conditions. Reaction. Bioconjugation involves the conjugation (attachment) of a probe to a biomolecule, such as DNA, RNA, carbohydrates and proteins. This probe can be a reporter, such as a fluorescent or biotinylated molecule, or a substrate targeted to a specific biomolecule.

There are different kinds of click chemistry reactions, including copper-catalyzed azido-alkyl cyclization (CuAAC), copper-free, strain-promoted azido-alkyl cyclization (SPAAC), and strain-promoted alkyl-azone cyclization (SPANC).

Biopharma PEG offers a wide range of PEG products for click chemistry reactions. Our azide functionalized products work well in both copper-catalyzed (CuAAC) and strain-promoted (SPAAC) azide-alkyne cyclization reactions. In addition, our DBCO functionalized products are also suitable for SPAAC reactions. (DBCO PEGs for Copper-Free Click Chemistry)

Technique support: GMP standard production support, parameter control. Contact for Technical Files.

References:
1. Sethiya, A., Sahiba, N., Agarwal, S., 2021, 'Role of Click Chemistry in Organic Synthesis', in T. Akitsu (ed.), Current Topics in Chirality - From Chemistry to Biology, IntechOpen, London. 10.5772/intechopen.96146.
2. Kolb et al. (2001) Click chemistry: diverse chemical function from a few good reactions. Angew. Chem. Int. Ed. 40 (11):2004.

Catalog No.	Name	Structure	M.W.	Purity	Buy
MD006002	N3-PEG4-OH		219.238	≥95%

MD006002	N3-PEG8-OH		395.45	≥95%

MD006005	N3-PEG3-NH2		218.25	≥95%

MD006005	N3-PEG8-NH2		438.51

MD006005	N3-PEG11-NH2		570.7	≥95%

MD006016	N3-PEG12-COOH		643.72	≥95%

MD108006	Trityl-PEG7-N3		637.8	≥95%

MD006067	N3-PEG3-CH2CH2COOtBu		303.35	≥95%

MD006067	N3-PEG4-CH2CH2COOtBu		347.41	≥95%

MD006067	N3-PEG8-CH2CH2COOtBu		523.62	≥95%

MD006121	N3-PEG2-CH2COOH		189.17	≥95%

MD007002	Alkyne-PEG5-OH		276.3	≥95%

MD007006	Alkyne-PEG9-N3			≥95%

MD007056	Alkyne-PEG8-Br			≥95%

MD007067	Alkyne-PEG5-CH2CH2COOtBu		360.4	≥95%

MD048005	DBCO-PEG4-NH2		523.626	≥95%

MD253002	endo-BCN-PEG2-OH		325.4	≥95%

MD253005	endo-BCN-PEG3-Boc-amine		468.6	≥95%

MD253025	BCN-endo-PEG4-SPA		538.6	≥95%

MD253067	endo-BCN-PEG4-CH2CH2COOtBu		497.6	≥95%

MD253253	endo-BCN-PEG2-endo-BCN		500.6	≥95%

MF001048	mPEG-DBCO			≥95%

HE005048	NH2-PEG-DBCO			≥95%

HE006002	N3-PEG-OH			≥95%

HE006005	N3-PEG-NH2			≥95%

HO006006	N3-PEG-N3			≥95%

LP096048	DSPE-PEG-DBCO			≥95%

LP096291	DSPE-PEG-Man			≥95%

LP100057	DOPE-PEG-FA

HE007020	Alkyne-PEG-Silane			≥95%

HE048009	DBCO-PEG-AC			≥95%

HO048048	DBCO-PEG-DBCO			≥95%

HE048057	DBCO-PEG-FA

HE048022	DBCO-PEG-Mal			≥95%

HE048023	DBCO-PEG-NHS			≥95%

HE048003	DBCO-PEG-SH			≥95%

HE048020	DBCO-PEG-Silane			≥95%

LP101002	STA-PEG-OH			≥95%

A44048	4-ArmPEG-DBCO			≥95%

A88048	8-ArmPEG-DBCO			≥95%