Click chemistry involves efficient organic reactions of two or more highly functionalized chemical entities under ecologically benign conditions for the synthesis of different heterocycles. Some organic reactions, such as nucleophilic ring-opening reactions, cycloaddition reactions, nucleophilic addition reactions, thiol-ene reactions, and Diels Alder reactions are included in click reactions. These reactions have very important characteristics, i.e. high functional group tolerance, formation of single products, high atomic economy, high yields, no need for column purification, etc.

Due to its biocompatibility, click chemistry is widely used for bioconjugation: the selective joining of small building blocks by rapid and irreversible one-pot reaction under mild conditions. Reaction. Bioconjugation involves the conjugation (attachment) of a probe to a biomolecule, such as DNA, RNA, carbohydrates and proteins. This probe can be a reporter, such as a fluorescent or biotinylated molecule, or a substrate targeted to a specific biomolecule.

There are different kinds of click chemistry reactions, including copper-catalyzed azido-alkyl cyclization (CuAAC), copper-free, strain-promoted azido-alkyl cyclization (SPAAC), and strain-promoted alkyl-azone cyclization (SPANC).

Biopharma PEG offers a wide range of PEG products for click chemistry reactions. Our azide functionalized products work well in both copper-catalyzed (CuAAC) and strain-promoted (SPAAC) azide-alkyne cyclization reactions. In addition, our DBCO functionalized products are also suitable for SPAAC reactions.​ (DBCO PEGs for Copper-Free Click Chemistry)

Technique support: GMP standard production support, parameter control. Contact for Technical Files.

References:
1. Sethiya, A., Sahiba, N., Agarwal, S., 2021, 'Role of Click Chemistry in Organic Synthesis', in T. Akitsu (ed.), Current Topics in Chirality - From Chemistry to Biology, IntechOpen, London. 10.5772/intechopen.96146.
2. Kolb et al. (2001) Click chemistry: diverse chemical function from a few good reactions. Angew. Chem. Int. Ed. 40 (11):2004.

Catalog No.	Name	Structure	M.W.	Purity	Buy
MF001048	mPEG-DBCO			≥95%	BUY
HO006006	N3-PEG-N3			≥95%	BUY
HO048048	DBCO-PEG-DBCO			≥95%	BUY
HE006002	N3-PEG-OH			≥95%	BUY
HE006005	N3-PEG-NH2			≥95%	BUY
HE048003	DBCO-PEG-SH			≥95%	BUY
HE048020	DBCO-PEG-Silane			≥95%	BUY
HE048022	DBCO-PEG-Mal			≥95%	BUY
HE048057	DBCO-PEG-FA			≥95%	BUY
HE007020	Alkyne-PEG-Silane			≥95%	BUY
A44048	4-ArmPEG-DBCO			≥95%	BUY
A88048	8-ArmPEG-DBCO			≥95%	BUY