Release date:2020/7/10 9:41:03
Polyethylene glycol (PEG) is the most biocompatible synthetic polymer material. In addition to being widely used for long-term and synergistic effects of drugs, the application of PEG in medical devices is also being continuously developed. In view of its advantages of solubility, good biocompatibility, non-toxicity, and low immunogenicity, PEG materials can be widely used in the adhesion, hemostasis, anti-leakage, and anti-adhesion of wounds in various surgical operations on the human body. At the same time, PEG materials can also be used as a raw material for medical devices implanted in the human body, replacing the widely used plant source, animal source and human source materials, so it has a very wide range of medical uses.
multi-arm PEG derivatives are mainly used in these medical device products. Multi-arm PEG derivatives can form hydrogels due to their relatively large molecular weights and have good water-resisting properties and high tissue activity. With the help of this characteristic of PEG material, it can be made into a hydrogel medical device for hemostasis and tissue isolation, which can be gradually degraded in the human body and completely discharged to the body. The above-mentioned tissue sealant or tissue-isolated medical device can be widely used in surgical operations or tumor radiotherapy and has a broad prospect.
At present, there are many PEG-modified medical device products on the market, such as: DuraSeal product lines of Integra Life Sciences (used owned by Covidien, a unit of Medtronic), Mynx product lines of Cardinal Health, SpaceOAR product lines and Baxter CoSeal product lines of Augmenix ( a unit of Boston Scientific), etc. The main PEG hydrogel medical device products in the European and American markets are as follows.

Product Name Company Type of PEG Molecular Weight Application
Covidien/Medtronic 4-Arm PEG  20K Dural Sealant System 
Covidien/Medtronic 4-Arm PEG  20K Spinal Sealant System
Covidien/Medtronic Multi-Arm PEG 15K Spinal Sealant System
SpaceOar Augmenix/Boston Scientific 8-Arm PEG 15K Minimize Side Effects of Radiation Therapy for Prostate Cancer
MYNX Access
Closure / Cardinal Health
4-Arm & 8-Arm PEG 10K/20K extravascular vascular closure device
Adherus Hyperbranch 4-Arm PEG  20K Dural Sealant System 
CoSeal Baxter 4-Arm PEG 10K Skin closure surgery
ReSure Ocular Therapeutix Multi-Arm PEG 15K Ocular sealant, sealing clear corneal incisions following cataract surgery
Note: DuraSeal product lines have been acquired by Integra LifeSciences Holdings Corporation. Find more applications of PEG linkers.

At present, surgical suturing and hemostasis are the main applications of PEG hydrogel products, including ophthalmology, brain repair, and spine surgery. After spraying the hydrogel with PEG derivatives as the main component to the wound site, the hydrogel quickly solidifies to prevent wound bleeding and infection and degrades itself after the wound heals. At the same time, spraying this hydrogel onto the surface of the organ can effectively prevent the internal organs from adhering during the operation and causing the disease to deteriorate. Because PEG derivatives have good biocompatibility, this process will not cause abnormal reactions in humans. Moreover, PEG derivatives will not be absorbed by the body, and will eventually be excreted by the body through metabolism. Taking CoSeal as an example, CoSeal is composed of PEG and polyethylene. When sprayed on the surface of tissue, it can quickly cross-link with the protein on the surface of the tissue and form mechanical adhesion, quickly seal the vascular suture, which can reduce air leakage when used in lung surgery.
Tissue isolation in radiotherapy is a frontier application field of PEG hydrogel products. SpaceOAR produced by Augmenix, Inc. was launched in 2015. It is the first tissue isolation product used in the United States for radiation therapy of prostate cancer. Hydrogels exist in the form of water injections, which can quickly form a soft, gel-like synthetic material between the prostate and rectum after injection. Clinical studies have shown that SpaceOAR can reduce rectal mucosal damage in patients receiving high-dose radiation therapy from 90% to 13.6%.

At present, PEG has been widely used in hydrogel medical devices, and it is expected that future application prospects will also be quite broad. Biochempeg provides
multi-arm PEG derivatives, including 4-arm and 8-arm PEG products, as well as some other PEG products with special structures, which can be used to crosslink into degradable PEG hydrogels.
 4arm PEG Succinimidyl Carboxymethyl Ester  Hydrogel 
 4arm PEG Amine  Hydrogel 
 4arm PEG Thiol  Hydrogel 
 8arm PEG Amine (tripentaerythritol), HCl Salt  Hydrogel 
 8arm PEG Amine, HCl Salt Hydrogel 
8arm PEG Thiol (hexaglycerol)  Hydrogel 
Acrylate PEG NHS Ester  Hydrogel
Methoxy PEG Amine  Hydrogel 

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List of PEG Derivatives Application
One of PEG Applications: Surface Modification

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