Generally, multi-arm PEG derivatives are mainly used in these medical device products. Multi-arm PEG derivatives can form hydrogels due to their relatively large molecular weights and have good water-resisting properties and high tissue activity. With the help of this characteristic of PEG material, it can be made into a hydrogel medical device for hemostasis and tissue isolation, which can be gradually degraded in the human body and completely discharged to the body. The above-mentioned tissue sealant or tissue-isolated medical device can be widely used in surgical operations or tumor radiotherapy and has a broad prospect.
At present, there are many PEG-modified medical device products on the market, such as: DuraSeal product lines of Integra Life Sciences (used owned by Covidien, a unit of Medtronic), Mynx product lines of Cardinal Health, SpaceOAR product lines and Baxter CoSeal product lines of Augmenix ( a unit of Boston Scientific), etc. The main PEG hydrogel medical device products in the European and American markets are as follows.
|Product Name||Company||Type of PEG||Molecular Weight||Application|
|Covidien/Medtronic||4-Arm PEG||20K||Dural Sealant System|
|Covidien/Medtronic||4-Arm PEG||20K||Spinal Sealant System|
|Covidien/Medtronic||Multi-Arm PEG||15K||Spinal Sealant System|
|SpaceOar||Augmenix/Boston Scientific||8-Arm PEG||15K||Minimize Side Effects of Radiation Therapy for Prostate Cancer|
Closure / Cardinal Health
|4-Arm & 8-Arm PEG||10K/20K||extravascular vascular closure device|
|Adherus||Hyperbranch||4-Arm PEG||20K||Dural Sealant System|
|CoSeal||Baxter||4-Arm PEG||10K||Skin closure surgery|
|ReSure||Ocular Therapeutix||Multi-Arm PEG||15K||Ocular sealant, sealing clear corneal incisions following cataract surgery|
Note: DuraSeal product lines have been acquired by Integra LifeSciences Holdings Corporation. Find more applications of PEG linkers.
At present, surgical suturing and hemostasis are the main applications of PEG hydrogel products, including ophthalmology, brain repair, and spine surgery. After spraying the hydrogel with PEG derivatives as the main component to the wound site, the hydrogel quickly solidifies to prevent wound bleeding and infection and degrades itself after the wound heals. At the same time, spraying this hydrogel onto the surface of the organ can effectively prevent the internal organs from adhering during the operation and causing the disease to deteriorate. Because PEG derivatives have good biocompatibility, this process will not cause abnormal reactions in humans. Moreover, PEG derivatives will not be absorbed by the body, and will eventually be excreted by the body through metabolism. Taking CoSeal as an example, CoSeal is composed of PEG and polyethylene. When sprayed on the surface of tissue, it can quickly cross-link with the protein on the surface of the tissue and form mechanical adhesion, quickly seal the vascular suture, which can reduce air leakage when used in lung surgery.
Tissue isolation in radiotherapy is a frontier application field of PEG hydrogel products. SpaceOAR produced by Augmenix, Inc. was launched in 2015. It is the first tissue isolation product used in the United States for radiation therapy of prostate cancer. Hydrogels exist in the form of water injections, which can quickly form a soft, gel-like synthetic material between the prostate and rectum after injection. Clinical studies have shown that SpaceOAR can reduce rectal mucosal damage in patients receiving high-dose radiation therapy from 90% to 13.6%.
At present, PEG has been widely used in hydrogel medical devices, and it is expected that future application prospects will also be quite broad. Biochempeg provides multi-arm PEG derivatives, including 4-arm and 8-arm PEG products, as well as some other PEG products with special structures, which can be used to crosslink into degradable PEG hydrogels.
|4arm PEG Succinimidyl Carboxymethyl Ester||Hydrogel|
|4arm PEG Amine||Hydrogel|
|4arm PEG Thiol||Hydrogel|
|8arm PEG Amine (tripentaerythritol), HCl Salt||Hydrogel|
|8arm PEG Amine, HCl Salt||Hydrogel|
|8arm PEG Thiol (hexaglycerol)||Hydrogel|
|Acrylate PEG NHS Ester||Hydrogel|
|Methoxy PEG Amine||Hydrogel|
What are the Uses of PEG Derivatives & Polyethylene Glycols (PEGs)
List of PEG Derivatives Application
One of PEG Applications: Surface Modification