PEG Linkers

Polyethylene glycol (PEG) is a general term for glycol polymers with relative molecular masses of 200-8000 and more than 8000, which have excellent lubricity, moisturizing properties, dispersibility, and adhesive properties. The PEG linkers (PEG derivatives) can be made by precisely introducing reactive functionalized groups at specific molecular ends of PEG through chemical synthesis reactions. Since a variety of groups can be introduced, PEG linkers have greatly expanded their original application scope on the basis of inheriting various excellent properties of PEG. which are widely used in peptide and protein drugs, small molecule drugs, ADC drug linkers, gene-drug (siRNA, mRNA) delivery and hydrogel-based devices, etc. 

PEG linkers have attracted considerable interest and are widely used in biological and medical research due to their solubility in water, excellent biocompatibility, and non-immunogenicity. PEG linkers have had a significant impact on medical research with the ability to prolong the circulation half-life, improve solubility and reduce protease sensitivity of the drug. In addition, biomolecules modified with PEG linkers show enhanced resistance to degradation in organisms, better pharmacokinetics, and the ability to cross the blood-brain barrier.

There are two types of PEG linkers, monodispersed, polydispersed and multi-arm PEGs. Monodispersed PEGs or discrete PEGs have a precise number of PEG units with a specific single chemical structure and a precise molecular weight. Whereas, polydispersed PEG is a mixture of polymers with an average molecular weight.

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Biopharma PEG has over 3000 high purity PEG linkers in stock to empower your PEGylation, bioconjugation, crosslinking, ADC drug development, biolabeling for pharmaceutical and biotech R&D.

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