Linker chemistry determines the stability of the drug conjugates (ADCs / PDCs) and the payload release rate. There are currently two main types of linker chemistry: cleavable and non-cleavable.
- ▶ Cleavable linkers contain a trigger that can release the cytotoxic agent after internalization. Cleavable linkers may also help with destroying cancer cells adjacent to their targets through a process referred to as "bystander effect".
- ▶ Non-cleavable linkers rely on the degradation of the antibody itself to release the drug-linker.
Biopharma PEG provides large-scale GMP manufacture of high-purity PEG linkers for your XDCs research and development.
Non-Cleavable PEG Linkers
Cleavable PEG Linkers