Linker chemistry determines the stability of the drug conjugates (ADCs / PDCs) and the payload release rate. There are currently two main types of linker chemistry: cleavable and non-cleavable.
- ▶ Cleavable linkers contain a trigger that can release the cytotoxic agent after internalization. Cleavable linkers may also help with destroying cancer cells adjacent to their targets through a process referred to as "bystander effect".
- ▶ Non-cleavable linkers rely on the degradation of the antibody itself to release the drug-linker.
Biopharma PEG provides large-scale GMP manufacture of high-purity PEG linkers for your XDCs research and development.
Non-Cleavable PEG Linkers
| Name | Cas No | Structure |
| 2-((Azido-PEG8-carbamoyl)methoxy)acetic acid | 846549-37-9 |  |
| mPEG36-NH2 | 32130-27-1 |  |
| N3-PEG3-SPA | 1245718-89-1 |  |
| N3-PEG3-COOH | 1056024-94-2 |  |
| NH2-PEG4-OH | 86770-74-3 |  |
| OH-PEG9-OH | 3386-18-3 |  |
Cleavable PEG Linkers
| Name | Structure |
| 4-ArmPEG-SG |  |
| 4-ArmPEG-SS |  |
| 8-ArmPEG-SG |  |
| 8-ArmPEG-SS |  |