• CAS No.：
  86770-74-3
• Synonyms：
  NH2-PEG4
  1-Amino-3,6,9-trioxaundecanyl-11-ol
  11-Amino-3,6,9-trioxaundecanol
  2-(2-(2-(2-Hydroxyethoxy)ethoxy)ethoxy)ethylamine
  Amino-PEG4-alcohol
  2-(2-(2-(2-aminoethoxy)ethoxy)ethoxy)ethanol
  
• Purity：
  ≥95%
• MF：
  C₈H₁₉NO₄
• MW：
  193.2
• Recommended Storage Condition：
  Store at -5°C,keep in dry and avoid sunlight.
• Uses：
  

Amino-PEG4-alcohol (NH2-PEG4-OH) is a PEG linker containing an amino group (NH2) with a hydroxyl group (OH). The amino group can react with carboxylic acids, reactive NHS esters, carbonyl groups (ketones, aldehydes), etc. The hydroxyl group can be further derivatized or replaced with other reactive functional groups.

It is a non-cleavable 4 unit PEG ADC linker used for antibody-drug conjugates (ADCs). And, it is also a PROTAC linker for the synthesis of PROTACs.

Biopharma PEG offers a wide range of PEG products from lab to commercial scale in both non-GMP and GMP grades. Email at sales@biochempeg.com and start using a superior product for your next product R&D project.

References:
[1]. Nello Mainolfi, et al. Protein degraders and uses thereof. WO2019060742A1.
[2]. Miller MA, et al. Modular Nanoparticulate Prodrug Design Enables Efficient Treatment of Solid Tumors Using Bioorthogonal Activation. ACS Nano. 2018 Dec 26;12(12):12814-12826.