2-((Azido-PEG8-carbamoyl)methoxy)acetic acid
2-((Azido-PEG8-carbamoyl)methoxy)acetic acid

CatalogID: 12277 Purity: ≥95% CAS NO.: 846549-37-9

  • CAS No.:
    846549-37-9
  • Synonyms:
    o-(2-azidoethyl)-o-(2-(diglycolyl-amino)ethyl)eg-7
  • Purity:
    ≥95%
  • MF:
    C22H42N4O12
  • MW:
    554.6
  • Recommended Storage Condition:
    Store at -5°C,keep in dry and avoid sunlight.
  • Uses:

2-((Azido-PEG8-carbamoyl)methoxy)acetic acid (CAS NO.: 846549-37-9)  is a PEG linker containing an azide group with a terminal carboxylic acid. It is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs

2-((Azido-PEG8-carbamoyl)methoxy)acetic acid can also act as a linker for Antibody-Drug Conjugates (ADCs)

References:
​1. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562
2. Zheng Su, Dian Xiao, Fei Xie, Lianqi Liu, Yanming Wang, Shiyong Fan, Xinbo Zhou, Song Li, Antibody–drug conjugates: Recent advances in linker chemistry, Acta Pharmaceutica Sinica B, Volume 11, Issue 12, 2021,Pages 3889-3907, ISSN 2211-3835, https://doi.org/10.1016/j.apsb.2021.03.042.