Boc-NH-PEG11-N3
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MSDS
Boc-NH-PEG11-N3

CatalogID: 12097 Purity: ≥89% CAS NO.: 2395004-21-2

  • CAS No.:
    2395004-21-2
  • Synonyms:
    BocNH-PEG11-CH2CH2N3
    N3-PEG11-NH-Boc
  • Purity:
    ≥89%
  • MF:
    C29H58N4O13
  • MW:
    670.79
  • Recommended Storage Condition:
    Store at -5°C,keep in dry and avoid sunlight.
  • Uses:
    Applicated in medical research, drug-release, nanotechnology and new materials research, cell culture. In the study of ligand, polypeptide synthesis support, a graft polymer compounds, new materials, and polyethylene glycol-modified functional coatings and other aspects of the active compound.

t-Boc-N-Amido-PEG11-Azide (Boc-NH-PEG11-N3) includes both an azide group and a Boc-protected amino group. The PEG spacer boosts the compound's solubility in water. The azide group can participate in Click Chemistry reactions with alkyne, BCN, or DBCO, forming a stable triazole linkage. The Boc group can be deprotected under mild acidic conditions to form a free amine, which can undergo amide coupling with carboxylic acid bearing biomolecules.

Boc-NH-PEG11-N3 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

Large-scale PEGs and GMP-grade PEGs are made-to-order. Please contact us at sales@biochempeg.com for more details. 

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562