• Synonyms：
  Dibenzocycolctyne-PEG-Acid
  
• Purity：
  ≥95%
• Recommended Storage Condition：
  Store at -5°C,keep in dry and avoid sunlight.
• Uses：
  Applicated in medical research, drug-release, nanotechnology and new materials research, cell culture. In the study of ligand, polypeptide synthesis support, a graft polymer compounds, new materials, and polyethylene glycol-modified functional coatings and other aspects of the active compound.

DBCO-PEG-Acid (DBCO-PEG-COOH) is a heterobifunctional reactive PEG derivative featuring a dibenzocyclooctyne (DBCO) group and a carboxylic acid group at opposite ends of the PEG chain. The DBCO group allows for copper-free click chemistry with azide-containing molecules, enabling efficient and selective bioconjugation without the need for a catalyst. The carboxylic acid group can be activated for coupling reactions with primary amines, forming stable amide bonds. This dual functionality makes DBCO-PEG-COOH ideal for a variety of applications, including targeted drug delivery, protein modification, and the development of advanced biomaterials and nanomedicine platforms. 

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Cited Publications

This PEG derivative has been cited in peer-reviewed scientific publications. Browse the references below to learn more.

1. Kyung Mu Noh, Ashok Kumar Jangid, Eunha Kim, Kyobum Kim, Click Chemistry Mediated Immune Synapse Augmentation in Natural Killer Cell–Cancer Membrane Engagement and Facilitated Anticancer Efficacies of Natural Killer Cell Therapy, Biomaterials Research, Volume 30, 2026, ISSN 2055-7124, https://doi.org/10.34133/bmr.0376.

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