• Synonyms：
  Mal-PEG-NHS
  Maleimide-PEG-NHS
  
• Purity：
  ≥95%
• Recommended Storage Condition：
  Store at -5°C,keep in dry and avoid sunlight.
• Uses：
  Applicated in medical research, drug-release, nanotechnology and new materials research, cell culture. In the study of ligand, polypeptide synthesis support, a graft polymer compounds, new materials, and polyethylene glycol-modified functional coatings and other aspects of the active compound.

Mal-PEG-SC, also known as Maleimide-PEG-NHS, is a heterobifunctional maleimide PEG derivative consisting of a maleimide group (Mal) and an N-hydroxysuccinimide (NHS) ester group linked by a PEG spacer. The maleimide group selectively reacts with thiol (-SH) groups to form stable thioether bonds, while the NHS ester group reacts with primary amines (-NH2) to form stable amide bonds. Its bifunctional structure allows for the precise and controlled attachment of biomolecules, drugs, or targeting ligands to surfaces, nanoparticles, or other substrates.

Due to this bifunctional structure, Mal-PEG-SC is commonly used in the construction of antibody–drug conjugates (ADCs), protein labeling and crosslinking, nanoparticle surface functionalization, biosensor development, and hydrogel formation. 

Biopharma PEG offers a wide range of maleimide PEG products from lab to commercial scale. Email at [email protected] and start using a superior product for your next product R&D project.

Cited Publications

This PEG derivative has been cited in peer-reviewed scientific publications. Browse the references below to learn more.

1. Zhou, S., Furutani, Y., Yamashita, K., Kako, S., Watanabe, K., Kiwa, T., Ohtsuki, T., Zhou, S., Furutani, Y., Yamashita, K., Kako, S., Watanabe, K., Kiwa, T., & Ohtsuki, T. (2026). Magnetic Detection of Cancer Cells Using Tumor-Homing Peptide-Modified Magnetic Nanoparticles. Biosensors, 16(1). https://doi.org/10.3390/bios16010045
2. Zhou, S.; Tsutsumiuchi, K.; Imai, R.; Miki, Y.; Kondo, A.; Nakagawa, H.; Watanabe, K.; Ohtsuki, T. In Vitro Study of Tumor-Homing Peptide-Modified Magnetic Nanoparticles for Magnetic Hyperthermia. Molecules 2024, 29, 2632. https://doi.org/10.3390/molecules29112632 
3. Lamptey, R. N., Gothwal, A., Trivedi, R., Arora, S., & Singh, J. (2022). Synthesis and Characterization of Fatty Acid Grafted Chitosan Polymeric Micelles for Improved Gene Delivery of VGF to the Brain through Intranasal Route. Biomedicines, 10(2), 493. https://doi.org/10.3390/biomedicines10020493

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