CatalogID: 10761 Purity: ≥95% CAS NO.: 1374666-32-6

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  • Synonyms:
    3-[2-[2-(2,5-Dihydro-2,5-dioxo-1H-pyrrol-1-yl)ethoxy]ethoxy]propanoic acid
    α-Maleimidyl-ω-propionyloxy poly(ethylene glycol)
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  • Recommended Storage Condition:
    Store at -5°C,keep in dry and avoid sunlight.
  • Uses:
    Applicated in medical research, drug-release, nanotechnology and new materials research, cell culture. In the study of ligand, polypeptide synthesis support, a graft polymer compounds, new materials, and polyethylene glycol-modified functional coatings and other aspects of the active compound.

Mal-PEG2-COOH, also known as Mal-PEG2-acid, is a PEG derivative with a maleimide functional group (-Mal) at one end and a carboxylic acid group (-COOH) at the other end.

The maleimide group is highly reactive towards thiol groups (SH), enabling the selective conjugation of Mal-PEG2-COOH to biomolecules containing thiol groups through a Michael addition reaction. This reaction forms stable thioether linkages, facilitating the attachment of Mal-PEG2-COOH to proteins, peptides, or other molecules.

Additionally, the carboxylic acid group provides versatility for further chemical modification. It can be activated using coupling reagents such as EDC or HATU to form stable amide bonds with molecules containing amino groups.

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