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CatalogID: 10584 Purity: ≥95% CAS NO.: 201467-81-4
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CAS No.:
201467-81-4 -
Synonyms:
Azide-PEG4-CH2COOH
14-Azido-3,6,9,12-tetraoxatetradecanoic acid
14-Azido-3,6,9,12-tetraoxa-1-tetradecanoic acid
2-[2-[2-[2-(2-azidoethoxy)ethoxy]ethoxy]ethoxy]ethanoic acid
N3-TEG-COOH
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Purity:
≥95% -
MF:
C10H19N3O6 -
MW:
277.27 -
Recommended Storage Condition:
Store at -5°C,keep in dry and avoid sunlight. -
Uses:
Applicated in medical research, drug-release, nanotechnology and new materials research, cell culture. In the study of ligand, polypeptide synthesis support, a graft polymer compounds, new materials, and polyethylene glycol-modified functional coatings and other aspects of the active compound.
Monodisperse Azido-PEG4-CH2COOH (N3-PEG4-CH2COOH) is a very popular click chemistry linker containing an azide (N3) group with a terminal carboxylic acid (CH2COOH). The hydrophilic PEG spacer increases solubility in aqueous media. The azide group can react with alkyne, BCN, DBCO via Click Chemistry to yield a stable triazole linkage. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU).
It is also a PROTAC linker containing four polyethylene glycol (PEG) units.
References:
[1]. Zengerle M, et al. Selective Small Molecule Induced Degradation of the BET Bromodomain Protein BRD4. ACS Chem Biol. 2015 Aug 21;10(8):1770-7.

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