CatalogID: 10732 Purity: ≥95% CAS NO.: 1446282-18-3

  • CAS No.:
  • Synonyms:
    Amino-PEG5-t-butyl ester
    tert-Butyl 1-amino-3,6,9,12,15-pentaoxaoctadecan-18-oate
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  • Recommended Storage Condition:
    Store at -5°C,keep in dry and avoid sunlight.
  • Uses:
    Applicated in medical research, drug-release, nanotechnology and new materials research, cell culture. In the study of ligand, polypeptide synthesis support, a graft polymer compounds, new materials, and polyethylene glycol-modified functional coatings and other aspects of the active compound.

Monodisperse Amino-PEG5-t-butyl ester (NH2-PEG5-CH2CH2COOtBu) is a heterobifunctional, PEGylated crosslinker features an amino (NH2) group at one end and t-butyl-protected carboxyl group at the other, which can be deprotected with acidic conditions. The hydrophillic PEG linker facilitates solubility in biological applications. It can be used for bioconjugation or as a building block for synthesis of small molecules, conjugates of small molecules and/or biomolecules, or other tool compounds for chemical biology and medicinal chemistry that require ligation. Examples of applications include its synthetic incorporation into antibody-drug conjugates or proteolysis-targeting chimeras (PROTAC® molecules) for targeted protein degradation.

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