NHS-PEG-NHS, SC-PEG-SC, Succinimidyl ester-PEG-Succinimidyl ester

Products

MSDS

NHS-PEG-NHS

≥95% CatalogID: 10066 Purity: ≥95%

Synonyms：
SC-PEG-SC
Succinimidyl ester-PEG-Succinimidyl ester
Purity：
≥95%
Recommended Storage Condition：
Store at -5°C,keep in dry and avoid sunlight.
Uses：
Applicated in medical research, drug-release, nanotechnology and new materials research, cell culture. In the study of ligand, polypeptide synthesis support, a graft polymer compounds, new materials, and polyethylene glycol-modified functional coatings and other aspects of the active compound.

NHS-PEG-NHS is an amino (-NH 2) reactive PEG derivative, which can be used to modify proteins, peptides or any other surface.
The NHS ester reacts with the primary amine group of pH 7~8.5 to form a stable amide bond. NHS esters react with deprotonated primary amines, therefore, the reaction requires neutral to alkaline pH to proceed. Primary amines react with NHS esters through nucleophilic attack, and NHS is released as a by-product. The competition between the hydrolysis of NHS-ester and the reaction in the aqueous solution increases with the increase of pH.
Compared with other PEG NHS ester derivatives, the succinimide carbonate (SC) functionalized mPEG-NHS of NHS-PEG-NHS provides excellent reactivity and higher stability in aqueous solutions.