CatalogID: 10066

  • Synonyms:
    Succinimidyl ester-PEG-Succinimidyl ester
  • Recommended Storage Condition:
  • Uses:

NHS-PEG-NHS is an amino (-NH2) reactive PEG derivative, which can be used to modify proteins, peptides or any other surface.

The NHS ester reacts with the primary amine group of pH 7~8.5 to form a stable amide bond. NHS esters react with deprotonated primary amines, therefore, the reaction requires neutral to alkaline pH to proceed. Primary amines react with NHS esters through nucleophilic attack, and NHS is released as a by-product. The competition between the hydrolysis of NHS-ester and the reaction in the aqueous solution increases with the increase of pH.

Compared with other PEG NHS ester derivatives, the succinimide carbonate (SC) functionalized mPEG-NHS of NHS-PEG-NHS provides excellent reactivity and higher stability in aqueous solutions.