• Synonyms：
  Hydroxy-PEG-acid
  α-hydroxyl-ω-carboxyl poly(ethylene glycol)
  HO-PEG-COOH
  
• Purity：
  ≥95%
• Recommended Storage Condition：
  Store at -5°C,keep in dry and avoid sunlight.
• Uses：
  Applicated in medical research, drug-release, nanotechnology and new materials research, cell culture. In the study of ligand, polypeptide synthesis support, a graft polymer compounds, new materials, and polyethylene glycol-modified functional coatings and other aspects of the active compound.

OH-PEG-COOH, also known as α-hydroxyl-ω-carboxyl poly(ethylene glycol), is a linear heterobifunctional PEG derivative with one hydroxyl group and one carboxyl group. It is a useful cross-linking reagent with a PEG spacer. The hydroxyl group (-OH) can react with succinic anhydride, halogenated hydrocarbons, and other reagents to introduce functional groups such as carboxyl or amino groups. The carboxyl group  (-COOH) typically requires activation with coupling agents such as EDC/NHS, enabling efficient amide bond formation with amino groups for covalent conjugation to biomolecules.

Applications: 
● Nanoparticle surface modification: The hydroxyl group can be used to modify nanoparticle surfaces to improve hydrophilicity, while the carboxyl group enables covalent attachment of targeting ligands (e.g., antibodies, peptides) or therapeutic molecules.
● Drug delivery systems: Serves as a key crosslinker for controlled coupling of drugs with targeting ligands, enhancing delivery efficiency.
● Biosensors: The carboxyl group enables immobilization of enzymes or proteins, while the hydroxyl group allows attachment of fluorescent probes or other signal molecules, thereby improving detection sensitivity and performance.
● Tissue engineering: Used to modify the surface of biomaterial scaffolds, for example by conjugating RGD peptides via the carboxyl group to promote cell adhesion.
● Protein modification: Provides site-directed PEGylation through the carboxyl group, effectively prolonging the half-life of protein therapeutics and reducing immunogenicity.

Cited Publications

This PEG derivative has been cited in peer-reviewed scientific publications. Browse the references below to learn more.

1. Shortwave Infrared Hemicyanine-6 for Cancer-Activated and Shaving-Free Preclinical Imaging of Lung Metastasis, Hanyu Yang, Donghao Li, Jiayan Wu, and Kanyi Pu, Journal of the American Chemical Society Article ASAP, DOI: 10.1021/jacs.5c06682
2. Xin Zhou, Pengbo Zhang, Haibo Ding, Hao Wang, Zhongze Gu, Enhanced antibiofilm photodynamic therapy: Leveraging the slow photon effect for maximized efficacy with minimal photosensitizer and light doses, Nano Today,Volume 56,2024, 102225, ISSN 1748-0132, https://doi.org/10.1016/j.nantod.2024.102225. 
3. Yoon, S., Kim, Y., Youn, Y. S., Oh, K. T., Kim, D., & Lee, E. S. (2020). Transferrin-Conjugated pH-Responsive γ-Cyclodextrin Nanoparticles for Antitumoral Topotecan Delivery. Pharmaceutics, 12(11), 1109. https://doi.org/10.3390/pharmaceutics12111109

View more publications citing Biopharma PEG products.

Related Products & Categories

• ● Category: Heterobifunctional PEGs | Carboxylic Acid PEGs | Hydroxyl(OH) PEG
• ● Heterobifunctional PEGs: OH-PEG-NH2 | NH2-PEG-COOH | NHS-PEG-COOH | MAL-PEG-COOH | Azide-PEG-COOH | Biotin-PEG-COOH
• ● Linear & Functional PEGs: HO-PEG-OH | mPEG-COOH | mPEG-OH
• ● Monodisperse PEG Linkers: HO-PEG3-COOH | HO-PEG4-COOH | HO-PEG6-COOH | HO-PEG8-COOH