• Synonyms：
  Hydroxy-PEG-acid
  α-hydroxyl-ω-carboxyl poly(ethylene glycol)
  
• Purity：
  ≥95%
• Recommended Storage Condition：
  Store at -5°C,keep in dry and avoid sunlight.
• Uses：
  Applicated in medical research, drug-release, nanotechnology and new materials research, cell culture. In the study of ligand, polypeptide synthesis support, a graft polymer compounds, new materials, and polyethylene glycol-modified functional coatings and other aspects of the active compound.

OH-PEG-COOH, also known as α-hydroxyl-ω-carboxyl poly(ethylene glycol), is a linear heterobifunctional PEG derivative with one hydroxyl group and one carboxyl group. It is a useful cross-linking reagent with a PEG spacer. The hydroxyl group (-OH) can react with succinic anhydride, halogenated hydrocarbons, and other reagents to introduce functional groups such as carboxyl or amino groups. The carboxyl group  (-COOH) typically requires activation with coupling agents such as EDC/NHS, enabling efficient amide bond formation with amino groups for covalent conjugation to biomolecules.

Applications:
Nanoparticle surface modification: The hydroxyl group can be used to modify nanoparticle surfaces to improve hydrophilicity, while the carboxyl group enables covalent attachment of targeting ligands (e.g., antibodies, peptides) or therapeutic molecules.
Drug delivery systems: Serves as a key crosslinker for controlled coupling of drugs with targeting ligands, enhancing delivery efficiency.
Biosensors: The carboxyl group enables immobilization of enzymes or proteins, while the hydroxyl group allows attachment of fluorescent probes or other signal molecules, thereby improving detection sensitivity and performance.
Tissue engineering: Used to modify the surface of biomaterial scaffolds, for example by conjugating RGD peptides via the carboxyl group to promote cell adhesion.
Protein modification: Provides site-directed PEGylation through the carboxyl group, effectively prolonging the half-life of protein therapeutics and reducing immunogenicity.

Biopharma PEG offers a wide range of PEG products from lab to commercial scale in both non-GMP and GMP grades. Email at sales@biochempeg.com and start using a superior product for your next product R&D project.

Cited Publications

This PEG derivative has been cited in peer-reviewed scientific publications. Browse the references below to learn more.

1. Shortwave Infrared Hemicyanine-6 for Cancer-Activated and Shaving-Free Preclinical Imaging of Lung Metastasis, Hanyu Yang, Donghao Li, Jiayan Wu, and Kanyi Pu, Journal of the American Chemical Society Article ASAP, DOI: 10.1021/jacs.5c06682
2. Xin Zhou, Pengbo Zhang, Haibo Ding, Hao Wang, Zhongze Gu, Enhanced antibiofilm photodynamic therapy: Leveraging the slow photon effect for maximized efficacy with minimal photosensitizer and light doses, Nano Today,Volume 56,2024, 102225, ISSN 1748-0132, https://doi.org/10.1016/j.nantod.2024.102225. 
3. Yoon, S., Kim, Y., Youn, Y. S., Oh, K. T., Kim, D., & Lee, E. S. (2020). Transferrin-Conjugated pH-Responsive γ-Cyclodextrin Nanoparticles for Antitumoral Topotecan Delivery. Pharmaceutics, 12(11), 1109. https://doi.org/10.3390/pharmaceutics12111109

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