• CAS No.：
  77544-68-4
• Synonyms：
  Tos-PEG3-alcohol
  Hydroxy-PEG3-Tos
  Triethylene glycol p-toluenesulfonate
  2-(2-(2-Hydroxyethoxy)ethoxy)ethyl 4-methylbenzenesulfonate
  
• Purity：
  ≥95%
• MF：
  C₁₃H₂₀O₆S
• MW：
  304.359
• Recommended Storage Condition：
  Store at -5°C,keep in dry and avoid sunlight.
• Uses：
  

OH-PEG3-Tos is a PEG linker with a hydroxyl group and a tosyl group at each end. The hydrophilic PEG spacer increases the solubility in aqueous media. The hydroxyl group can be further derivatized or substituted with other reactive functional groups. For nucleophilic substitution reactions, the tosyl group is a very good leaving group.

Tos-PEG3 is a PEG-based PROTAC linker for the synthesis of PROTACs. Tos-PEG3 can be used for the synthesis of 3'-aminooxy oligonucleotide solid supports.

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References:
​Noël M, et al. Solid Supports for the Synthesis of 3'-Aminooxy Deoxy- or Ribo-oligonucleotides and Their 3'-Conjugation by Oxime Ligation.J Org Chem. 2019 Nov 15;84(22):14854-14860.