OH-PEG3-Tos
OH-PEG3-Tos

CatalogID: 11726 Purity: ≥95% CAS NO.: 77544-68-4

  • CAS No.:
    77544-68-4
  • Purity:
    ≥95%
  • MF:
    C13H20O6S
  • MW:
    304.359
  • Recommended Storage Condition:
    Store at -5°C,keep in dry and avoid sunlight.
  • Uses:

OH-PEG3-Tos is a PEG linker with a hydroxyl group and a tosyl group at each end. The hydrophilic PEG spacer increases the solubility in aqueous media. The hydroxyl group can be further derivatized or substituted with other reactive functional groups. For nucleophilic substitution reactions, the tosyl group is a very good leaving group.

Tos-PEG3 is a PEG-based PROTAC linker for the synthesis of PROTACs. Tos-PEG3 can be used for the synthesis of 3'-aminooxy oligonucleotide solid supports.

Biopharma PEG offers a wide range of PEG products from lab to commercial scale in both non-GMP and GMP grades. Email at sales@biochempeg.com and start using a superior product for your next product R&D project.

References:
​Noël M, et al. Solid Supports for the Synthesis of 3'-Aminooxy Deoxy- or Ribo-oligonucleotides and Their 3'-Conjugation by Oxime Ligation.J Org Chem. 2019 Nov 15;84(22):14854-14860.