• Synonyms：
  Thiol-PEG-Acid
  
• Purity：
  ≥95%
• Recommended Storage Condition：
  Store at -5°C,keep in dry and avoid sunlight.
• Uses：
  Applicated in medical research, drug-release, nanotechnology and new materials research, cell culture. In the study of ligand, polypeptide synthesis support, a graft polymer compounds, new materials, and polyethylene glycol-modified functional coatings and other aspects of the active compound.

SH-PEG-COOH is soluble in most organic solvents, which can increase solubility and stability, and reduce the immunogenicity of peptides and proteins. As sulfhydryl PEG, SH-PEG-COOH can also be used to modify nano-AU materials.

Cited Publications

This PEG derivative has been cited in peer-reviewed scientific publications. Browse the references below to learn more.

1. Khosroshahi, M. E., Senthilchelvan, G., & Oyebolu, V. (2025). Microfluidic Nanosensor for Label-Free Multiplexed Detection of Breast Cancer Biomarkers via Surface-Enhanced Reflective FTIR Spectroscopy Using Thin Gold Films and Antibody-Oriented Gold Nanourchin: Feasibility Study. Micromachines, 16(11), 1268. https://doi.org/10.3390/mi16111268
2. Intracranial Surface-Enhanced Raman Scattering Endoscopy for In Vivo Protein Quantification under Physiological Stimulation, Maryam Hojjat Jodaylami, Dominic Falardeau, Antoine Malescot, Ravi L. Rungta, Arlette Kolta, and Jean-François Masson, ACS Sensors Article ASAP, https://doi.org/10.1021/acssensors.5c03517
3. Xu, W.; Maruyama, S.; Niidome, T. Modification of Silver-Loaded Biodegradable Polymer Nanoparticles with Bacterial Membrane Vesicles for Treating Intracellular Bacterial Infections. Materials 2025, 18, 3470. https://doi.org/10.3390/ma18153470​
4. Khosroshahi, M. E., Gaoiran, C., Umashanker, V., Veeru, H., & Panday, P. (2025). Dual-Oriented Targeted Nanostructured SERS Label-Free Immunosensor for Detection, Quantification, and Analysis of Breast Cancer Biomarker Concentrations in Blood Serum. Biosensors, 15(7), 447. https://doi.org/10.3390/bios15070447
5. ​Chi-Ping Huang, Wen-Pin Hu, Wei Yang, Zheng-Jie Lee, Wen-Yih Chen, In silico maturation of DNA aptamer against the prostate-specific antigen (PSA) and kinetic analysis, Biochemical and Biophysical Research Communications, Volume 759, 2025, 151638, ISSN 0006-291X, https://doi.org/10.1016/j.bbrc.2025.151638. 
6. Joung, H.; Jang, G.J.; Jeong, J.Y.; Lim, G.; Han, S.Y. Evaluating the In Situ Effects of Whole Protein Coronas on the Biosensing of Antibody-Immobilized Nanoparticles Using Two-Color Fluorescence Nanoparticle Tracking Analysis. Nanomaterials 2025, 15, 220. https://doi.org/10.3390/nano15030220 
7. Reipa, V.; Hackley, V.A.; Tona, A.; Heo, M.B.; Lee, Y.R.; Lee, T.G.; Johnston-Peck, A.; Cho, T.J. Well-Characterized Polyethyleneimine-/Carboxylated-Polyethylene-Glycol-Functionalized Gold Nanoparticles as Prospective Nanoscale Control Materials for In Vitro Cell Viability Assays: Particle Characterization and Toxicity Tests in Eight Mammalian Cell Lines. Nanomaterials 2025, 15, 79. https://doi.org/10.3390/nano15020079  
8. Enhanced Stability and Sensitivity for CA-125 Detection Under Microfluidic Shear Flow Using Polyethylene Glycol-Coated Biosensor
   Yudong Wang, Niladri Talukder, Bharath Babu Nunna, Ming Lu, Xiao Tong, and Eon Soo Lee, ACS Omega 2025 10 (1), 692-702, DOI: 10.1021/acsomega.4c07596 
9. Khosroshahi, M.E.; Patel, Y.; Umashanker, V. Targeted FT-NIR and SERS Detection of Breast Cancer HER-II Biomarkers in Blood Serum Using PCB-Based Plasmonic Active Nanostructured Thin Film Label-Free Immunosensor Immobilized with Directional GNU-Conjugated Antibody. Sensors 2024, 24, 5378. https://doi.org/10.3390/s24165378 
10.  Mohammad E. Khosroshahi, Yesha Patel, Vithurshan Umashanker, Christine Gaoiran,
    Fabrication of and characterization of directional antibody-conjugated gold nanourchin colloid and effect of laser polarization on SERS detection of breast cancer biomarker in serum, Colloids and Surfaces A: Physicochemical and Engineering Aspects, Volume 694, 2024, 134035, ISSN 0927-7757, https://doi.org/10.1016/j.colsurfa.2024.134035. 
11. Choi, Y., Son, W., Han, Y., Chae, J., Yang, C., & Choi, J. (2023). Glycan targeting nanoparticle for photodynamic immunotherapy of melanoma. Acta Pharmaceutica Sinica B, 13(5), 1903-1918. https://doi.org/10.1016/j.apsb.2022.08.009 
12. Aido, A., Zaitseva, O., Wajant, H., Buzgo, M., & Simaite, A. (2021). Anti-Fn14 Antibody-Conjugated Nanoparticles Display Membrane TWEAK-Like Agonism. Pharmaceutics, 13(7), 1072. https://doi.org/10.3390/pharmaceutics13071072 
13. Baldacchini, C., Montanarella, A. F., Francioso, L., Signore, M. A., Cannistraro, S., & Bizzarri, A. R. (2019). A Reliable BioFET Immunosensor for Detection of p53 Tumour Suppressor in Physiological-Like Environment. Sensors, 20(21), 6364. https://doi.org/10.3390/s20216364 
14. Sau, S., Petrovici, A., Alsaab, H. O., Bhise, K., & Iyer, A. K. (2019). PDL-1 Antibody Drug Conjugate for Selective Chemo-Guided Immune Modulation of Cancer. Cancers, 11(2), 232. https://doi.org/10.3390/cancers11020232

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