• CAS No.：
  1032347-93-5
• Synonyms：
  Thiol-PEG12-acid
  Mercapto carboxy polyethylene glycol
  
• Purity：
  ≥95%
• MF：
  C₂₇H₅₄O₁₄S
• MW：
  634.8
• Recommended Storage Condition：
  Store at -5°C,keep in dry and avoid sunlight.
• Uses：
  Applicated in medical research, drug-release, nanotechnology and new materials research, cell culture. In the study of ligand, polypeptide synthesis support, a graft polymer compounds, new materials, and polyethylene glycol-modified functional coatings and other aspects of the active compound.

SH-PEG12-COOH (CAS NO.: 1032347-93-5) is a PEG linker with a thiol group and a terminal carboxylic acid. The hydrophilic PEG spacer improves solubility in aqueous media. The thiol group is highly reactive with maleimide, OPSS, vinylsulfone, and transition metal surfaces like gold and silver. The terminal carboxylic acid can react with primary amines in the presence of activators such as EDC or HATU to form stable amide bonds.

SH-PEG12-COOH is commonly used to form conjugates with gold nanoparticles for applications in neuroimaging and drug delivery. Its versatile reactivity makes it an excellent choice for bioconjugation and advanced biomedical applications.

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