• CAS No.：
  57-88-5
• MF：
  C₂₇H₄₆O
• MW：
  386.65
• Recommended Storage Condition：
  
• Uses：
  

Biological source: synthetic

Cholesterol, an important component of the cell plasma membrane, has a wide range of uses. Cholesterol can be used not only as pharmaceutical excipients, but also as raw materials for high-end cosmetics, starting materials for the synthesis of vitamin D3, and for a variety of osteopontanol series of APIs and feed additives, etc.

It is worth mentioning that cholesterol is a structural “helper” lipid making up a significant part of the lipid nanoparticle (LNP) formulations (40-50%) and enhances particle stability by regulating membrane integrity and rigidity.

Traditionally, cholesterol has been derived from eggs or animal sources. However, these sources can be linked to undesired immunological responses, inconsistent quality, and may require stricter regulatory controls. 

Biopharma PEG can supply USP grade cholesterol (plant-derived) from lab to large scale to meet your research and drug development needs. We also provide PEG lipids and DSPE for your LNP formulation development. Contact us at sales@biochempeg.com for more details. 

References:
​[1] Cheng X, Lee RJ. The role of helper lipids in lipid nanoparticles (LNPs) designed for oligonucleotide delivery. Adv Drug Deliv Rev. 2016;99(Pt A):129-137. doi:10.1016/j.addr.2016.01.022
[2] Jung HN, Lee SY, Lee S, Youn H, Im HJ. Lipid nanoparticles for delivery of RNA therapeutics: Current status and the role of in vivo imaging. Theranostics. 2022 Oct 24;12(17):7509-7531. doi: 10.7150/thno.77259. PMID: 36438494; PMCID: PMC9691360.