CatalogID: 11845 Purity: ≥95% CAS NO.: 564476-32-0

  • CAS No.:
  • Synonyms:
    Bromo-PEG4-t-butyl ester
    15-Bromo-4,7,10,13-tetraoxapentadecanoic acid tert-butyl ester
    3,6,9,12-Tetraoxapentadecan-15-oic acid, 1-bromo-, 1,1-dimethylethylester
  • Purity:
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  • Recommended Storage Condition:
    Store at -5°C,keep in dry and avoid sunlight.
  • Uses:
    Applicated in medical research, drug-release, nanotechnology and new materials research, cell culture. In the study of ligand, polypeptide synthesis support, a graft polymer compounds, new materials, and polyethylene glycol-modified functional coatings and other aspects of the active compound.

Br-PEG4-CH2CH2COOtBu, also known as Bromo-PEG4-t-butyl ester, is a type of PEG linker featuring a bromide group (Br) and a t-butyl protected carboxyl group (COOtBu). The bromide group acts as a leaving group in nucleophilic substitution reactions, facilitating the conjugation of the linker to biomolecules or other substrates through nucleophilic attack. The t-butyl protected carboxyl group serves as a temporary protecting group for the carboxylic acid functionality, which can be selectively removed under acidic conditions, revealing a reactive carboxyl group for further conjugation reactions.

Besides, Br-PEG4-CH2CH2COOtBu is a cleavable ADC linker with four units of PEG, making it suitable for the synthesis of ADCs. 

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