• Synonyms：
  DBCO-PEG-SC
  Dibenzocycolctyne-PEG-NHS
  
• Purity：
  ≥95%
• Recommended Storage Condition：
  Store at -5°C,keep in dry and avoid sunlight.
• Uses：
  Protein-peptide conjugates;• Antibody-enzyme or antibody-drug conjugates;• Protein or peptide-oligonucleotide conjugates;• Surface modification .

DBCO-PEG-NHS is a PEG derivative with a dibenzocyclooctyne (DBCO) functional group and an N-hydroxysuccinimide (NHS) ester moiety. The NHS ester group enables the selective coupling of the DBCO-PEG molecule to primary amines on biomolecules, such as proteins and peptides. The DBCO functional group further facilitates bioconjugation via copper-free click chemistry, specifically with molecules containing azide groups. This reaction, known as strain-promoted azide-alkyne cycloaddition (SPAAC), enables rapid, biocompatible, and specific conjugation under physiological conditions without the need for toxic catalysts. 

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Cited Publications

This PEG derivative has been cited in peer-reviewed scientific publications. Browse the references below to learn more.

1. ​Lee, R., Sim, S., Park, J., Park, W., & Joung, Y. K. (2023). Targeted Delivery of Apoptotic Cell-Derived Nanovesicles prevents Cardiac Remodeling and Attenuates Cardiac Function Exacerbation. Advanced Functional Materials, 33(23), 2210864. https://doi.org/10.1002/adfm.202210864

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