• Synonyms：
  DBCO-PEG-SC
  Dibenzocycolctyne-PEG-NHS
  
• Purity：
  ≥90%
• Recommended Storage Condition：
  Store at -5°C,keep in dry and avoid sunlight.
• Uses：
  Protein-peptide conjugates;• Antibody-enzyme or antibody-drug conjugates;• Protein or peptide-oligonucleotide conjugates;• Surface modification .

DBCO-PEG-NHS is a PEG derivative with a dibenzocyclooctyne (DBCO) functional group and an N-hydroxysuccinimide (NHS) ester moiety. The NHS ester group enables the selective coupling of the DBCO-PEG molecule to primary amines on biomolecules, such as proteins and peptides. The DBCO functional group further facilitates bioconjugation via copper-free click chemistry, specifically with molecules containing azide groups. This reaction, known as strain-promoted azide-alkyne cycloaddition (SPAAC), enables rapid, biocompatible, and specific conjugation under physiological conditions without the need for toxic catalysts. 

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Cited Publications

This PEG derivative has been cited in peer-reviewed scientific publications. Browse the references below to learn more.

1. Van Hieu Duong, Van Dat Bui, Torsha Ghosh, Jeongyun Kim, Won Ho Jang, Sol Shin, Chan Ho Kim, Um Wooram, Sohyun Cho, Chaemin Lee, Chan-Hwa Chung, Soyoung Son, Jae Hyung Park, Metabolically engineered chimeric probiotic-cancer vesicles orchestrate anti-tumor systemic immunity, Journal of Controlled Release, 2026, 115442, ISSN 0168-3659, https://doi.org/10.1016/j.jconrel.2026.115442
2. ​Lee, R., Sim, S., Park, J., Park, W., & Joung, Y. K. (2023). Targeted Delivery of Apoptotic Cell-Derived Nanovesicles prevents Cardiac Remodeling and Attenuates Cardiac Function Exacerbation. Advanced Functional Materials, 33(23), 2210864. https://doi.org/10.1002/adfm.202210864

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