• Synonyms：
  Dibenzocycolctyne-PEG-Hydroxy
  
• Purity：
  ≥95%
• Recommended Storage Condition：
  Store at -5°C,keep in dry and avoid sunlight.
• Uses：
  Applicated in medical research, drug-release, nanotechnology and new materials research, cell culture. In the study of ligand, polypeptide synthesis support, a graft polymer compounds, new materials, and polyethylene glycol-modified functional coatings and other aspects of the active compound.

DBCO-PEG-OH (DBCO-PEG-Alcohol) is a heterobifunctional reactive PEG derivative. This compound features a DBCO (dibenzocyclooctyne) group on one end and a hydroxyl (OH) group on the other. The DBCO group is known for its ability to perform copper-free click chemistry, reacting specifically with azide groups, making it useful for bioorthogonal labeling and conjugation. The hydroxyl group can be further derivatized or replaced with other functional groups for diverse applications. 

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Cited Publications

This PEG derivative has been cited in peer-reviewed scientific publications. Browse the references below to learn more.

1. Ringaci, A., Shih, TY. & Grinstaff, M.W. Supramolecular coiled-coil peptide platform for site-specific antibody drug conjugate engineering. Nat Commun (2026). https://doi.org/10.1038/s41467-026-70094-y
2. A Supramolecular Self-assembly Approach to Site-Specific Antibody Conjugates via a Coiled-coil Peptides Platform, Alina Ringaci, Ting-Yu Shih, Mark W. Grinstaff bioRxiv 2025.07.21.665979; doi: https://doi.org/10.1101/2025.07.21.665979
3. ​Jain Koo, Yuseon Shin, Hyewon Jeon, Jaehyun Cheong, Seongmin Cho, Chanho Park, Ee Chan Song, Jacob D. Ramsey, Chaemin Lim, Kyung Taek Oh, Enhancing glioblastoma therapy via intranasal administration of highly potent cell-penetrating peptide decorated nanoparticles, Journal of Controlled Release, Volume 378, 2025, Pages 997-1012, ISSN 0168-3659, https://doi.org/10.1016/j.jconrel.2024.12.058.

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