• CAS No.：
  86770-67-4
• Synonyms：
  Azido-PEG4-Hydroxy
  Azido-PEG4-alcohol
  11-Azido-3,6,9-trioxaundecanolsolution
  1-Azido-3,6,9-trioxaundecan-11-olsolution
  2-{2-[2-(2-Azidoethoxy)ethoxy]ethoxy}ethanolsolution
  2-[2-[2-(2-Azidoethoxy)ethoxy]ethoxy]ethanol
  
• Purity：
  ≥95%
• MF：
  C₈H₁₇N₃O₄
• MW：
  219.238
• Recommended Storage Condition：
  Store at -5°C,keep in dry and avoid sunlight.
• Uses：
  

Azido-PEG4-alcohol (N3-PEG4-OH), is a click chemistry reagent consisting of an azide and a terminal hydroxyl group. The terminal azide reacts with alkyne, BCN, DBCO via click chemistry, such as copper(I)-catalyzed, ruthenium-catalyzed, and strain-promoted azide-alkyl cyclization reactions (CuAAC, RuAAC, and SPAAC, respectively). Without modification, the alcohol group increases the water solubility and the hydrodynamic volume of the molecules and surfaces to which it is conjugated. Modification of the alcohol with reactive groups (e.g., chloride, tosylate,, or mesylate) allows Azido-PEG4-alcohol to function as a crosslinker by subsequent chemical manipulation.

Biopharma PEG offers a wide range of PEG products (e.g. Azido-PEG4-alcohol) for click chemistry reactions including CuAAC, RuAAC, and SPAAC reactions. We are able to provide click chemistry reagents from lab to commercial scale in both non-GMP and GMP grades. Email at [email protected] and start using a superior product for your next product R&D project.

References:
1. Hein CD, Liu XM, Wang D. Click chemistry, a powerful tool for pharmaceutical sciences. Pharm Res. 2008;25(10):2216-2230. doi:10.1007/s11095-008-9616-1
​2. Greg T. Hermanson, Bioconjugate Techniques, 3rd Edition, Elsevier, Waltham, MA 02451, 2013, ISBN 978-0-12-382239-0; See Chapter 18, Discrete PEG Reagents, pp. 787-821, for a full overview of the dPEG® products.