N3-PEG8-COOH
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MSDS
N3-PEG8-COOH

CatalogID: 10579 Purity: ≥95% CAS NO.: 1214319-92-2

  • CAS No.:
    1214319-92-2
  • Synonyms:
    Azide-PEG8-COOH
  • Purity:
    ≥95%
  • MF:
    C19H37N3O10
  • MW:
    467.51
  • Recommended Storage Condition:
    Store at -5°C,keep in dry and avoid sunlight.
  • Uses:
    Applicated in medical research, drug-release, nanotechnology and new materials research, cell culture. In the study of ligand, polypeptide synthesis support, a graft polymer compounds, new materials, and polyethylene glycol-modified functional coatings and other aspects of the active compound.

Monodisperse Azido-PEG8-acid (N3-PEG8-COOH) is a aqueous soluble PEG linker containing an azide (N3) and a terminal carboxylic acid (COOH) group. The azide group can react with alkyne, BCN, DBCO via Click Chemistry to yield a stable triazole linkage. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond.

N3-PEG8-COOH is a non-cleavable ADC linker containing 8-unit PEG that can be used to synthesize antibody drug conjugates (ADCs). It is also a PROTAC linker, belonging to the PEG class, which can be used to synthesize PROTAC molecules.

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