• CAS No.：
  581065-95-4
• Synonyms：
  H2N-PEG4-CH2CH2COOtBu
  Amino-dPEG4-t-butylester
  Amino-PEG4-t-butylester
  tert-Butyl 15-amino-4,7,10,13-tetraoxapentadecanoate
  2-[2-[2-[2-(2-tert-Butoxycarbonylethoxy)ethoxy]ethoxy]ethoxy]ethylamine
  tert-Butyl1-amino-3,6,9,12-tetraoxapentadecan-15-oate
  
• Purity：
  ≥95%
• MF：
  C₁₅H₃₁NO₆
• MW：
  321.4
• Recommended Storage Condition：
  Store at -5°C,keep in dry and avoid sunlight.
• Uses：
  

Monodisperse Amino-PEG4-t-butyl ester (NH2-PEG4-CH2CH2COOtBu) is a heterobifunctional PEG reagent containing an amino (NH2) and a t-butyl protected carboxyl group. The hydrophilic PEG spacer increases solubility in aqueous media. The amino group is reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde) etc. The t-butyl protected carboxyl (Boc) can be deprotected under acidic conditions.

Amino-PEG4-t-butyl ester has various uses, it can be used for bioconjugation or as a building block for the synthesis of small molecules, conjugates of small molecules and/or biomolecules, or other tool compounds for chemical biology and medicinal chemistry that require ligation, such as 1) act as a linker-cytotoxin conjugate for antibody-drug conjugates (ADCs); 2) act as a linker for peptide-drug conjugate formation; 3) synthetic incorporation into proteolysis-targeting chimeras (PROTAC® molecules) for targeted protein degradation

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References:
1. Chemical Modification of Silicon Surfaces for Biological Applications. Michael P. Schwartz, Frédérique Cunin, Ronnie W. Cheung, Michael J. Sailor. physica status solidi. 2005, 202 (8) pp 1380-1384. May 23, 2005. 10.1002/pssa.200461106.