NH2-PEG4-COOH
NH2-PEG4-COOH

CatalogID: 10699 Purity: ≥95% CAS NO.: 663921-15-1

  • CAS No.:
    663921-15-1
  • Synonyms:
    Amine-PEG4-COOH;α-amine-ω-propionic acid tetraethylene glycol
    3-[2-[2-[2-(2-Aminoethoxy)ethoxy]ethoxy]ethoxy]propionicacid
    1-Amino-3,6,9,12-tetraoxapentadecan-15-oicacid
    Amino-PEG4-acid
    H2N-PEG4-CH2CH2COOH
    Amino-dPEG4-acid
    1-Amino-3,6,9,12-tetraoxa-15-pentadecanoic acid
  • Purity:
    ≥95%
  • MF:
    C11H23NO6
  • MW:
    265.3
  • Recommended Storage Condition:
    Store at -5°C,keep in dry and avoid sunlight.
  • Uses:
    Applicated in medical research, drug-release, nanotechnology and new materials research, cell culture. In the study of ligand, polypeptide synthesis support, a graft polymer compounds, new materials, and polyethylene glycol-modified functional coatings and other aspects of the active compound.

NH2-PEG4-COOH (Amino-PEG4-propionic acid) is a PEG linker that can be used as drug carrier, ADC linker and PROTAC linker. It has been shown to have a high uptake in cancer cells and tumor vasculature. It creates conjugates with drugs or radiotracers to facilitate their delivery into the tumor. This polymer can be synthesized on a solid phase and conjugated to cytotoxic drugs or radiotracers via the amino group of its side chain. Amino-PEG4-propionic acid has also been shown to have low expression in normal cells, which makes it an effective carrier for drugs that are toxic to normal cells.
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