• CAS No.：
  756526-06-4
• Synonyms：
  Amino-PEG8-t-butyl ester
  H2N-PEG8-tBu
  Amino-PEG8-Boc
  
• Purity：
  ≥95%
• MF：
  C₂₃H₄₇NO₁₀
• MW：
  497.6
• Recommended Storage Condition：
  Store at -5°C,keep in dry and avoid sunlight.
• Uses：
  Applicated in medical research, drug-release, nanotechnology and new materials research, cell culture. In the study of ligand, polypeptide synthesis support, a graft polymer compounds, new materials, and polyethylene glycol-modified functional coatings and other aspects of the active compound.

NH2-PEG8-CH2CH2COOtBu (Amino-PEG8-t-butyl ester, CAS No. 756526-06-4) is a high-purity, monodisperse PEG linker designed for advanced bioconjugation applications. Featuring an amino group and a t-butyl protected carboxyl group, this versatile molecule enables robust coupling with carboxylic acids, activated NHS esters, and carbonyl-containing compounds such as ketones and aldehydes. The t-butyl protection provides stability during synthesis and can be efficiently removed under acidic conditions to reveal the free carboxyl group when needed.

This PEG8 linker is widely used in the synthesis of antibody-drug conjugates (ADCs), where its precisely cleavable eight-unit PEG chain improves solubility and pharmacokinetics while maintaining stability. Beyond ADCs, it is also suitable for targeted drug delivery systems and the development of multifunctional bioconjugates, enhancing therapeutic efficacy and specificity.

For researchers requiring GMP-grade PEG linkers, please contact us directly at [email protected].