• CAS No.：
  68865-60-1
• Synonyms：
  Thiol-PEG-Thiol
  Poly(ethylene glycol) dithiol
  
• Purity：
  ≥95%
• Recommended Storage Condition：
  Store at -5°C,keep in dry and avoid sunlight.
• Uses：
  Applicated in medical research, drug-release, nanotechnology and new materials research, cell culture. In the study of ligand, polypeptide synthesis support, a graft polymer compounds, new materials, and polyethylene glycol-modified functional coatings and other aspects of the active compound.

SH-PEG-SH is a polyethylene glycol compound containing sulfhydryl groups.

As a sulfhydryl functionalized PEG derivative, SH-PEG-SH can be used to modify proteins, peptides and other materials through amino acid or other acid active chemical groups.

SH-PEG-SH is generally biocompatible and relatively stable in organic and aqueous solutions, so it is widely used in biological applications, nanotechnology and material research.

Cited Publications

This PEG derivative has been cited in peer-reviewed scientific publications. Browse the references below to learn more.

1. Engineering a hybrid 3D construct for bone regeneration to promote simultaneous pre-vascularization and osteogenic differentiation in vitro, Sophia Dalfino, Sveva Fagiolino, Ivo Beeren, Marco Borrone, Francesco Alviano, Carlos Mota, Gianluca Tartaglia, Claudia Dolci, Lorenzo Moroni, bioRxiv 2026.05.06.723258; doi: https://doi.org/10.64898/2026.05.06.723258
2. A Versatile, Biocompatible Additive for Spatiotemporal Volumetric Photografting of Biochemical and Mechanical Cues in Diverse Hydrogel Matrices, Marc Falandt, Camille Bonhomme, Sammy Florczak, Tina Vermonden, Paulina Nunez Bernal, Riccardo Levato, bioRxiv 2026.01.20.700570; doi: https://doi.org/10.64898/2026.01.20.700570
3. Morgan, F. L. C. (2025). Bond. Dynamic bond: rational design of dynamic covalent soft matter and applications in tissue engineering. [Doctoral Thesis, Maastricht University]. Maastricht University. https://doi.org/10.26481/dis.20250114fm
4. ​Liu, G.W., Pickett, M.J., Kuosmanen, J.L.P. et al. Drinkable in situ-forming tough hydrogels for gastrointestinal therapeutics. Nat. Mater. 23, 1292–1299 (2024). https://doi.org/10.1038/s41563-024-01811-5 
5. ​Bio-inspired latent transforming growth factor beta scaffolds for cartilage regeneration, Wang, Tianbai, 2024, https://hdl.handle.net/2144/48874 
6. ​DiMartini, E.T.; Lowe, C.J.; Shreiber, D.I. Alternative Chemistries for Free Radical-Initiated Targeting and Immobilization. J. Funct. Biomater. 2023, 14, 153. https://doi.org/10.3390/jfb14030153 
7. Drinkable, liquid in situ-forming and tough hydrogels for gastrointestinal therapeutics, Gary W. Liu, Matthew J. Pickett, Johannes L. P. Kuosmanen, Keiko Ishida, Wiam A. M. Madani, Georgia N. White, Joshua Jenkins, Vivian R. Feig, Miguel Jimenez, Aaron Lopes, Joshua Morimoto, Nina Fitzgerald, Jaime H. Cheah, Christian K. Soule, Niora Fabian, Alison Hayward, Robert S. Langer, Giovanni Traverso, bioRxiv 2022.12.15.520584; doi: https://doi.org/10.1101/2022.12.15.520584

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