• Synonyms：
  4-ArmPEG-Norbornene
  
• Recommended Storage Condition：
  
• Uses：
  

4-ArmPEG-Norbornene (4-ArmPEG-NB) is a tetra-functional PEG derivative featuring four arms, each terminated with a norbornene group. Norbornene is a strained cyclic alkene that serves as a versatile reactive handle in bioconjugation and polymerization reactions.

4-Arm PEG-NB is widely used in the synthesis of hydrogels, polymer networks, and other biomaterials due to its ability to undergo crosslinking reactions. The norbornene groups enable the formation of stable hydrogels through thiol-ene or photo-click reactions, allowing for precise control over the mechanical properties and biocompatibility of the resulting materials.

This compound finds applications in tissue engineering, drug delivery, and regenerative medicine, where hydrogels with tailored properties are essential for mimicking the native extracellular matrix and promoting cell adhesion, proliferation, and tissue regeneration. 

Biopharma PEG offers a wide range of PEG products from lab to commercial scale in both non-GMP and GMP grades. Email at [email protected] and start using a superior product for your next product R&D project.

Cited Publications

This PEG derivative has been cited in peer-reviewed scientific publications. Browse the references below to learn more.

1. Adaptive PEG Bis-dendron Hydrogels with Tunable Mechanics and Bioactivity, Evgeny Apartsin, Noël Richard, Birgit Habenstein, Antoine Loquet, Sophie Lecomte, and Marie-Christine Durrieu, Chemistry of Materials Article ASAP, DOI: 10.1021/acs.chemmater.6c00419
2. A Novel Precision-cut lung slice stretch model using removable inflation materials, Cassidy Potter, Jeannie Haak, David Dean, Andrew M. Dylag, Jared A. Mereness, bioRxiv 2026.02.01.703167; doi: https://doi.org/10.64898/2026.02.01.703167
3. Nguyen, A. T., Johnson, R., Rafuse, M., Zhao, A., Madukwe, D., Battistella, A., & Tan, W. (2025). Sulfide-based, pro-regenerative, anti-inflammatory vascular grafts: Impregnation of slow-released sulfide signals into graft implants. Acta Biomaterialia. https://doi.org/10.1016/j.actbio.2025.12.032
4. Gentry, J. L., & Caliari, S. R. Norbornene Homopolymerization Limits Cell Spreading in Thiol–Ene Photoclick Hydrogels. Advanced Healthcare Materials, e02172. https://doi.org/10.1002/adhm.202502172
5. ​Norbornene homopolymerization limits cell spreading in thiol-ene photoclick hydrogels, James L. Gentry, Steven R. Caliari, bioRxiv 2025.04.18.648735; doi: https://doi.org/10.1101/2025.04.18.648735

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