• Synonyms：
  Cholesterol-PEG-Thiol
  
• Purity：
  ≥95%
• Recommended Storage Condition：
  Store at -5°C,keep in dry and avoid sunlight.
• Uses：
  Applicated in medical research, drug-release, nanotechnology and new materials research, cell culture. In the study of ligand, polypeptide synthesis support, a graft polymer compounds, new materials, and polyethylene glycol-modified functional coatings and other aspects of the active compound.

CLS-PEG-SH (Cholesterol-PEG-Thiol) is a lipophilic lipid PEG conjugate with a cholesterol (CLS) group and a thiol group (SH). This reagent is commonly used to modify the surfaces of biomolecules, enhancing their water solubility, stability, and biocompatibility. Cholesterol facilitates interaction with cell membranes, PEG reduces non-specific binding, and the thiol group provides an active site for chemical reactions. CLS-PEG-SH is widely used in drug delivery, bioimaging, and nanomedicine applications.

Biopharma PEG offers a wide range of PEG products from lab to commercial scale. Email at sales@biochempeg.com and start using a superior product for your next product R&D project.

Cited Publications

This PEG derivative has been cited in peer-reviewed scientific publications. Browse the references below to learn more.

1. ​​Marquant A, Berthelot J, Bich C, et al. Control of Physical and Biochemical Parameters Influencing Exogeneous Cargo Protein Association to Extracellular Vesicles Using Lipid Anchors Enables High Loading and Effective Intracellular Delivery. J Extracell Biol. 2025;4(5):e70048. Published 2025 May 14. doi:10.1002/jex2.70048 
2. Bottom-Up Assembly of Modular Systems for Trapping and Near-Infrared Light-Triggered Killing of Bacteria, https://doi.org/10.11588/heidok.00036370

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