mPEG-N,N-Ditetradecylacetamide (ALC-0159)
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mPEG-N,N-Ditetradecylacetamide (ALC-0159)

CatalogID: 12399 Purity: ≥95% CAS NO.: 1849616-42-7

  • CAS No.:
    1849616-42-7
  • Synonyms:
    mPEG-DTA
    Methoxypoly(ethylene glycol) ditetradecylacetamide
  • Purity:
    ≥95%
  • Recommended Storage Condition:
    Store at -5°C,keep in dry and avoid sunlight.
  • Uses:
    Applicated in medical research, drug-release, nanotechnology and new materials research, cell culture. In the study of ligand, polypeptide synthesis support, a graft polymer compounds, new materials, and polyethylene glycol-modified functional coatings and other aspects of the active compound.

mPEG-N,N-Ditetradecylacetamide, also called ALC-0159, mPEG-DTA, is a PEG/lipid conjugate (i.e. PEGylated lipid).  According to public information,  mPEG-DTA (ALC-0159) is one of the excipients of Pfizer's COVID-19 mRNA vaccine.

Biopharma PEG offers a wide range of PEG products from lab to commercial scale in both non-GMP and GMP grades. Besides PEG lipids, we can also provide helper lipids, such as cholesterol (plant-derived), and DSPE for your LNP formulation development. Email at sales@biochempeg.com and start using a superior product for your next product R&D project. 

References:
1.  Schoenmaker, Linde; Witzigmann, Dominik; Kulkarni, Jayesh A.; Verbeke, Rein; Kersten, Gideon; Jiskoot, Wim; Crommelin, Daan J. A. (2021-05-15). "mRNA-lipid nanoparticle COVID-19 vaccines: Structure and stability". International Journal of Pharmaceutics. 601: 120586. doi:10.1016/j.ijpharm.2021.120586. ISSN 0378-5173.
2.  "Public Assessment Report Authorisation for Temporary Supply COVID-19 mRNA Vaccine BNT162b2 (BNT162b2 RNA) concentrate for solution for injection" (PDF). Regulation 174. MHRA. 15 December 2020.