• CAS No.：
  1849616-42-7
• Synonyms：
  mPEG-DTA
  Methoxypoly(ethylene glycol) ditetradecylacetamide
  
• Purity：
  ≥95%
• Recommended Storage Condition：
  Store at -5°C,keep in dry and avoid sunlight.
• Uses：
  

mPEG-N,N-Ditetradecylacetamide, also called ALC-0159 or mPEG-DTA, is a PEGylated lipid widely used in lipid nanoparticle (LNP) drug delivery systems. As a PEG-lipid excipient, it helps form a protective hydrophilic layer around nanoparticles, improving stability, reducing immune recognition, and extending circulation time.

Public information shows that ALC-0159 was used in the Pfizer-BioNTech COVID-19 mRNA vaccine, where it played an important role in efficient encapsulation and delivery of the mRNA active ingredient.Because of these properties, mPEG-N,N-Ditetradecylacetamide is also valuable in research and development for mRNA vaccines, CRISPR, siRNA, and antisense oligonucleotide delivery.

Biopharma PEG offers a wide range of PEG products from lab to commercial scale in both non-GMP and GMP grades. Besides PEG lipids, we can also provide helper lipids, such as cholesterol (plant-derived), and DSPE for your LNP formulation development. Email at [email protected] and start using a superior product for your next product R&D project. 

Cited Publications

Our mPEG-N,N-Ditetradecylacetamide (CAS NO.: 1849616-42-7)  has been cited in peer-reviewed scientific publications. Browse the references below to learn more.

1. ​Masatoshi Maeki, Yuto Okada, Shuya Uno, Kaisei Sugiura, Yuichi Suzuki, Kento Okuda, Yusuke Sato, Masao Ando, Hiroyuki Yamazaki, Masaki Takeuchi, Akihiko Ishida, Hirofumi Tani, Hideyoshi Harashima, Manabu Tokeshi, Mass production system for RNA-loaded lipid nanoparticles using piling up microfluidic devices, Applied Materials Today, Volume 31, 2023, 101754, ISSN 2352-9407, https://doi.org/10.1016/j.apmt.2023.101754.

View more publications citing Biopharma PEG products.