• CAS No.：
  160743-62-4
• Synonyms：
  mPEG-Dimyristoyl glycerol
  Polyethylene glycol [PEG] dimyristoyl glycerol [DMG]
  
• Purity：
  ≥95%
• Recommended Storage Condition：
  Store at -5°C,keep in dry and avoid sunlight.
• Uses：
  

mPEG-DMG is an amphiphilic polymer formed by the covalent coupling of 1,2-dimyristoyl-sn-glycerol (DMG) and methoxy polyethylene glycol (mPEG).

It is a critical component in Lipid Nanoparticles (LNPs) used for mRNA delivery. According to public information, mPEG-DMG (PEG 2000 DMG) is one of the excipients of the COVID-19 vaccine, which can help reduce antibody association (opsonization) by serum proteins and clearance by phagocytes thus conferring longer systemic circulation. ​

In addition, mPEG-DMG is commonly used in the delivery of nucleic acid therapeutics such as siRNA, plasmid DNA, miRNA, and CRISPR-Cas9, and it can also be used to modify conventional liposomes to improve pharmacokinetic performance.

Biopharma PEG offers a wide range of PEG Lipids from lab to commercial scale in both non-GMP and GMP grades. Email at [email protected] and start using a superior product for your next product R&D project.

The mPEG-DMG has been cited in peer-reviewed scientific publications. Browse the references below to learn more.

1. Mora-Raimundo, P., Gilon, A., Kadosh, H., Richtman, Y., Sela, M., Ackerman, S., Chen, G., Abel, R., Kagan, S., Sharf-Pauker, N., Gigi, O., Abumanhal-Masarweh, H., Tripathi, U., Saada, M., Shemen, A., Link-Sourani, D., Shklover, J., Farah, R., Horowitz-Kraus, T., . . . Schroeder, A. (2025). Music enhances lipid nanoparticle brain delivery and mRNA transfection in brain cells. Journal of Controlled Release, 388, 114301. https://doi.org/10.1016/j.jconrel.2025.114301
2. Intracellular delivery of full-length antibodies via organ targeted lipid nanoparticles, Azmain Alamgir, Militsa Yaneva, Mor Sela, Patricia Mora-Raimundo, Souvik Ghosal, Anas Odeh, Peleg Hasson, Rory C Chien, Avi Schroeder, Matthew P DeLisa, Christopher A Alabi, bioRxiv 2025.09.26.678781; doi:, https://doi.org/10.1101/2025.09.26.678781
3. Sela M, Chen G, Kadosh H, Kagan T, Nicola R, Turutov S, Richtman Y, Zhige L, Albalak Menasherov MR, Kagan S, Schroeder T, Mora-Raimundo P, Kablan R, Egorov E, Odeh A, Abu-Raiya T, Ionita I, Freilich I, Kaneti G, Knani I, Arav Y, Leichtmann-Bardoogo Y, Tadmor K, Shklover J, Patriarchi T, Danino D, Hasson P, Ashery U, Zeisel A, Maoz BM, Laviv T, Radinsky K, Schroeder A. AI-Validated Brain Targeted mRNA Lipid Nanoparticles with Neuronal Tropism. ACS Nano. 2025 Sep 16. doi: 10.1021/acsnano.4c15013. Epub ahead of print. PMID: 40957853.​

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