• CAS No.：
  474922-26-4
• Synonyms：
  DSPE-PEG-Amine
  
• Purity：
  ≥95%
• Recommended Storage Condition：
  Store at -5°C,keep in dry and avoid sunlight.
• Uses：
  

DSPE-PEG-NH2 (DSPE-PEG-Amine) is an amine-functionalized PEG lipid consisting of  a hydrophobic C18 saturated  lipid anchor , a PEG spacer, and a terminal amino group. It is widely used in liposome formulation, lipid nanoparticle (LNP) development, targeted drug delivery, and nanomedicine research.

• ● Liposome & Micelle Surface Modification: The DSPE lipid anchor integrates into lipid bilayers, while the PEG segment provides steric stabilization and helps extend circulation half-life and reduce non-specific protein binding or cell adhesion.
• ● Targeted Drug Delivery: The terminal amine (-NH₂) enables conjugation with targeting molecules such as antibodies, peptides, aptamers, and folate, supporting the development of targeted liposomes and LNPs.
• ● Nucleic Acid & Small Molecule Delivery: Used in functionalized liposomes and lipid nanoparticles for the delivery of mRNA, siRNA, DNA, and small-molecule drugs, with the terminal amine providing a site for further surface functionalization.

Cited Publications

The DSPE-PEG-NH2  has been cited in peer-reviewed scientific publications. Browse the references below to learn more.

1. Kyung Mu Noh, Ashok Kumar Jangid, Eunha Kim, Kyobum Kim, Click Chemistry Mediated Immune Synapse Augmentation in Natural Killer Cell–Cancer Membrane Engagement and Facilitated Anticancer Efficacies of Natural Killer Cell Therapy, Biomaterials Research, Volume 30, 2026, ISSN 2055-7124, https://doi.org/10.34133/bmr.0376.
2. Jo, Ha Young and Kwak, Myoung Jin and Gwak, Seongjin and Nam, Min-Ho and Oh, Soo-Jin and Rhee, Won Jong, Bioinspired Brain Endothelial Nanovesicles Self-Armed with IL-4 for Dual-Targeted Synergistic Therapy of Parkinson’s Disease. Available at SSRN: https://ssrn.com/abstract=6881183 or http://dx.doi.org/10.2139/ssrn.6881183
3. Jangid, A. K., Lee, C. E., Ryu, M., Kim, S., & Kim, K. (2025). Development of Natural Killer Cell–Drug Conjugates via Membrane-Installed Liposomes for Pancreatic Cancer Treatment. Biomaterials Research, 29, 0285. https://doi.org/10.34133/bmr.0285
4. Kang, S.J., Lee, J.H., Rhee, W.J. (2024). Engineered plant-derived extracellular vesicles for targeted regulation and treatment of colitis-associated inflammation. Theranostics, 14(14), 5643-5661. https://doi.org/10.7150/thno.97139. 
5. F. Peter, V. M. Kadiri, R. Goyal, J. Hurst, S. Schnichels, A. Avital, M. Sela, P. Mora-Raimundo, A. Schroeder, M. Alarcón-Correa, P. Fischer, Degradable and Biocompatible Magnesium Zinc Structures for Nanomedicine: Magnetically Actuated Liposome Microcarriers with Tunable Release. Adv. Funct. Mater. 2024, 34, 2314265. https://doi.org/10.1002/adfm.202314265
6. M. Sela, M. Poley, P. Mora-Raimundo, S. Kagan, el., Brain-Targeted Liposomes Loaded with Monoclonal Antibodies Reduce Alpha-Synuclein Aggregation and Improve Behavioral Symptoms in Parkinson's Disease. Adv. Mater. 2023, 35, 2304654. https://doi.org/10.1002/adma.202304654 
7. Biomaterial-Mediated Exogenous Facile Coating of Natural Killer Cells for Enhancing Anticancer Efficacy toward Hepatocellular Carcinoma, Ashok Kumar Jangid, Sungjun Kim, Hyun Jin Kim, and Kyobum Kim, Bioconjugate Chemistry 2023 34 (10), 1789-1801, DOI: 10.1021/acs.bioconjchem.3c00335

View more publications citing Biopharma PEG products.

Related Technical Articles & Guides

• ● PEG Lipids: Definition, Structure & Key Applications 
• ● The Role of Four Lipid Components Of LNPs
• ● Ultimate Insight into PEG Derivatives and Its Application

Related Products & Categories

• ● Category: Lipids for Lipid Nanoparticles (LNPs)
• ● Phospholipid Building Block: DSPE , DPPE
• ● PEG Lipids:  mPEG-DSPE, mPEG-DMG 
• ● Functionalized PEG Lipids: DSPE-PEG-MAL , DSPE-PEG-NHS
• ● Targeting PEG Lipids:  DSPE-PEG-Mannose, DSPE-PEG-c(RGDyk) 
• ● Other LNP Lipids: Cholesterol (Plant-Derived)