• CAS No.：
  474922-26-4
• Synonyms：
  DSPE-PEG-Amine
  
• Purity：
  ≥95%
• Recommended Storage Condition：
  Store at -5°C,keep in dry and avoid sunlight.
• Uses：
  Applicated in medical research, drug-release, nanotechnology and new materials research, cell culture. In the study of ligand, polypeptide synthesis support, a graft polymer compounds, new materials, and polyethylene glycol-modified functional coatings and other aspects of the active compound.

DSPE-PEG-NH2 is a linear heterobifunctional PEGylation reagent with a DSPE phospholipid and an amine. DSPE-PEG-NH2 is used to modify liposome surface with biomolecules containing amine reactive groups (NHS, thiolate). It is a useful self-assembling reagent to prepare grafted or PEGylated liposome or micelle while also providing an amine group for bioconjugation. It is often used in targeted drug delivery with the lipid bilayer to improve drug solubility, the PEG to provide stealth property, extend circulation half-life and reduce non-specific protein binding or cell adhesion, and the amine group to bioconjugate targeting molecules including antibody, aptamer, protein, and peptide.

Biopharma PEG can provide high-purity DSPE-PEG-NH2 in GMP and non-GMP grades. Besides PEG lipids, we can also provide helper lipids, such as cholesterol (plant-derived), and DSPE for your LNP formulation development.Email us at sales@biochempeg.com for more details.

Cited Publications

This PEG derivative has been cited in peer-reviewed scientific publications. Browse the references below to learn more.

1. Kang, S.J., Lee, J.H., Rhee, W.J. (2024). Engineered plant-derived extracellular vesicles for targeted regulation and treatment of colitis-associated inflammation. Theranostics, 14(14), 5643-5661. https://doi.org/10.7150/thno.97139. 
2. F. Peter, V. M. Kadiri, R. Goyal, J. Hurst, S. Schnichels, A. Avital, M. Sela, P. Mora-Raimundo, A. Schroeder, M. Alarcón-Correa, P. Fischer, Degradable and Biocompatible Magnesium Zinc Structures for Nanomedicine: Magnetically Actuated Liposome Microcarriers with Tunable Release. Adv. Funct. Mater. 2024, 34, 2314265. https://doi.org/10.1002/adfm.202314265
3. M. Sela, M. Poley, P. Mora-Raimundo, S. Kagan, el., Brain-Targeted Liposomes Loaded with Monoclonal Antibodies Reduce Alpha-Synuclein Aggregation and Improve Behavioral Symptoms in Parkinson's Disease. Adv. Mater. 2023, 35, 2304654. https://doi.org/10.1002/adma.202304654 
4. Biomaterial-Mediated Exogenous Facile Coating of Natural Killer Cells for Enhancing Anticancer Efficacy toward Hepatocellular Carcinoma, Ashok Kumar Jangid, Sungjun Kim, Hyun Jin Kim, and Kyobum Kim, Bioconjugate Chemistry 2023 34 (10), 1789-1801, DOI: 10.1021/acs.bioconjchem.3c00335

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