• Synonyms：
  4-ArmPEG-Maleimide
  
• Purity：
  ≥95%
• Recommended Storage Condition：
  Store at -5°C,keep in dry and avoid sunlight.
• Uses：
  

4-ARM PEG-Mal is a multifunctional 4-arm PEG derivative featuring a central pentaerythritol core with thiol-reactive maleimide groups at each terminus. At physiological pH (6.5–7.5), these functional groups undergo efficient Michael addition with sulfhydryl-containing molecules to form stable thioether bonds. Its unique four-arm architecture provides high cross-linking density and multi-point connectivity, making it an ideal tool for site-specific protein/peptide modification, PEG hydrogel formation, and advanced drug delivery applications.

Cited Publications

The 4-ARM PEG-Mal has been cited in peer-reviewed scientific publications. Browse the references below to learn more.

1. Patricia López-Gómez, Nabila Mehwish, Maria-Pau Ginebra, Carlos Mas-Moruno, Bioactive and degradable peg hydrogels: A multifunctional approach for tissue regeneration and antibacterial protection, Biomaterials Advances, Volume 180, 2026, 214553, ISSN 2772-9508, https://doi.org/10.1016/j.bioadv.2025.214553.
2. Yeingst, T.J.; Helton, A.M.; Rawnaque, F.S.; Arrizabalaga, J.H.; Ravnic, D.J.; Simon, J.C.; Hayes, D.J. Focused Ultrasound-Mediated Release of Bone Morphogenetic Protein 2 from Hydrogels for Bone Regeneration. Gels 2025, 11, 120. https://doi.org/10.3390/gels11020120
3. Pranantyo, D., Yeo, C.K., Wu, Y. et al. Hydrogel dressings with intrinsic antibiofilm and antioxidative dual functionalities accelerate infected diabetic wound healing. Nat Commun 15, 954 (2024). https://doi.org/10.1038/s41467-024-44968-y 
4. Ginebra, M. (2023). Protease-degradable hydrogels with multifunctional biomimetic peptides for bone tissue engineering. Frontiers in Bioengineering and Biotechnology, 11, 1192436. https://doi.org/10.3389/fbioe.2023.1192436 
5. A covalently crosslinked bioink for multi-materials drop-on-demand 3D bioprinting of three-dimensional cell cultures, Robert H. Utama, Vincent T. G. Tan, Kristel C. Tjandra, Andrew Sexton, Duyen H. T. Nguyen, Aidan P. O’Mahony, Julio C. C. Ribeiro, Maria Kavallaris, J. Justin Gooding, bioRxiv 2021.02.18.431759; doi:, https://doi.org/10.1101/2021.02.18.431759

View more publications citing Biopharma PEG products.

Related Products & Categories

• ● Category: Multi-Arm PEG Derivatives | PEG Hydrogels
• ● Amine Hydrogel Crosslinkers: 4-Arm PEG-NH2 | 8-Arm PEG-NH2
• ● Multi-Arm NHS Esters: Y-shape-PEG-NHS | 4-Arm PEG-SG | 8-Arm PEG-SG | 4-Arm PEG-NHS
• ● Thiol Crosslinking Partners: 4-Arm PEG-SH | 8-Arm PEG-SH
• ● 8-Arm Counterparts: 8-Arm PEG-MAL