• Synonyms：
  4-ArmPEG-Maleimide
  
• Purity：
  ≥95%
• Recommended Storage Condition：
  
• Uses：
  

4 Arm-PEG-Maleimide (4-Arm PEG-MAL) is a thiol reactive multiarm PEG derivative with maleimide at each terminal of the four arms connected to one pentaerythritol core. Maleimides react with thiols or sulfhydryl-containing molecules at pH 6.5 to 7.5 via Michael addition to form a stable thioether bond. 4-ArmPEG-Mal can be used for site specific protein and peptide modification. It also can be cross-linked into PEG hydrogels.

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Cited Publications

This PEG derivative has been cited in peer-reviewed scientific publications. Browse the references below to learn more.

1. Patricia López-Gómez, Nabila Mehwish, Maria-Pau Ginebra, Carlos Mas-Moruno, Bioactive and degradable peg hydrogels: A multifunctional approach for tissue regeneration and antibacterial protection, Biomaterials Advances, Volume 180, 2026, 214553, ISSN 2772-9508, https://doi.org/10.1016/j.bioadv.2025.214553.
2. Yeingst, T.J.; Helton, A.M.; Rawnaque, F.S.; Arrizabalaga, J.H.; Ravnic, D.J.; Simon, J.C.; Hayes, D.J. Focused Ultrasound-Mediated Release of Bone Morphogenetic Protein 2 from Hydrogels for Bone Regeneration. Gels 2025, 11, 120. https://doi.org/10.3390/gels11020120
3. Pranantyo, D., Yeo, C.K., Wu, Y. et al. Hydrogel dressings with intrinsic antibiofilm and antioxidative dual functionalities accelerate infected diabetic wound healing. Nat Commun 15, 954 (2024). https://doi.org/10.1038/s41467-024-44968-y 
4. Ginebra, M. (2023). Protease-degradable hydrogels with multifunctional biomimetic peptides for bone tissue engineering. Frontiers in Bioengineering and Biotechnology, 11, 1192436. https://doi.org/10.3389/fbioe.2023.1192436 
5. A covalently crosslinked bioink for multi-materials drop-on-demand 3D bioprinting of three-dimensional cell cultures, Robert H. Utama, Vincent T. G. Tan, Kristel C. Tjandra, Andrew Sexton, Duyen H. T. Nguyen, Aidan P. O’Mahony, Julio C. C. Ribeiro, Maria Kavallaris, J. Justin Gooding, bioRxiv 2021.02.18.431759; doi:, https://doi.org/10.1101/2021.02.18.431759

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