• CAS No.：
  557756-85-1
• Synonyms：
  Fmoc-NH-PEG4-CH2CH2COOH
  Fmoc-15-amino-4,7,10,13-tetraoxapentadecacanoicacid
  3-[2-[2-[2-[2-(9H-Fluoren-9-ylmethoxycarbonylamino)ethoxy]ethoxy]ethoxy]ethoxy]propionicacid
  1-(9H-Fluoren-9-yl)-3-oxo-2,7,10,13,16-pentaoxa-4-azanonadecan-19-oicacid
  
• Purity：
  ≥95%
• MF：
  C₂₆H₃₃NO₈
• MW：
  487.5
• Recommended Storage Condition：
  Store at -5°C,keep in dry and avoid sunlight.
• Uses：
  

Fmoc-N-amido-PEG4-acid (Fmoc-NH-PEG4-COOH) is a PEG derivative containing an Fmoc-protected amine and a terminal carboxylic acid. The hydrophilic PEG spacer increases solubility in aqueous media. The Fmoc group can be deprotected under basic condition to obtain the free amine which can be used for further conjugations. The terminal carboxylic acid can be reacted with primary amine groups in the presence of activators (e.g. EDC, or DCC) to form a stable amide bond.

Fmoc-N-amido-PEG4-acid has various uses, such as 1) used as a cleavable ADC linker for antibody-drug conjugates (ADCs); 2) used as a PEG-based PROTAC linker for the synthesis of PROTACs.

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References:
1. ​An Y, Yan H, Dong Z, Satz AL. DNA-Compatible Click Reaction Employing In Situ Generated Azides from Boronic Acids. Curr Protoc. 2021 May;1(5):e125. doi: 10.1002/cpz1.125. PMID: 33956399.
2. Cai P, et al. Synthesis of C3-Alkylated Indoles on DNA via Indolyl Alcohol Formation Followed by Metal-FreeTransfer Hydrogenation. Org Lett. 2019 Aug 14.
3. Tano H, Oroujeni M, Vorobyeva A, et al. Comparative Evaluation of Novel 177Lu-Labeled PNA Probes for Affibody-Mediated PNA-Based Pretargeting. Cancers (Basel). 2021;13(3):500. Published 2021 Jan 28. doi:10.3390/cancers13030500