• CAS No.：
  882847-32-7
• Synonyms：
  Fmoc-NH-PEG5-CH2CH2COOH
  Fmoc-18-amino-4,7,10,13,16-pentaoxaoctadecanoic acid
  5,8,11,14,17-Pentaoxa-2-azaeicosanedioic acid 1-(9H-fluoren-9-ylmethyl) ester
  Fmoc-N-amido-PEG5-acid
  1-(9H-Fluoren-9-yl)-3-oxo-2,7,10,13,16,19-hexaoxa-4-azadocosan-22-oic acid
  3-
  
• Purity：
  ≥95%
• MF：
  C₂₈H₃₇NO₉
• MW：
  531.6
• Recommended Storage Condition：
  Store at -5°C,keep in dry and avoid sunlight.
• Uses：
  Applicated in medical research, drug-release, nanotechnology and new materials research, cell culture. In the study of ligand, polypeptide synthesis support, a graft polymer compounds, new materials, and polyethylene glycol-modified functional coatings and other aspects of the active compound.

Fmoc-N-amido-PEG5-acid (Fmoc-NH-PEG5-COOH) is a PEG derivative containing an Fmoc-protected amine and a terminal carboxylic acid. The hydrophilic PEG spacer increases solubility in aqueous media. The Fmoc group can be deprotected under basic condition to obtain the free amine which can be used for further conjugations. The terminal carboxylic acid can be reacted with primary amine groups in the presence of activators (e.g. EDC, or DCC) to form a stable amide bond.

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Cited Publications

This PEG derivative has been cited in peer-reviewed scientific publications. Browse the references below to learn more.

1. A Conjugate of an EGFR-Binding Peptide and Doxorubicin Shows Selective Toxicity to Triple-Negative Breast Cancer Cells Phi-Phung Than, Shih-Jing Yao, Emad Althagafi, and Kamaljit Kaur ACS Medicinal Chemistry Letters 2025 16 (1), 109-115 DOI: 10.1021/acsmedchemlett.4c00480

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