• CAS No.：
  756526-02-0
• Synonyms：
  Fmoc-NH-PEG8-CH2CH2COOH
  5,8,11,14,17,20,23,26-Octaoxa-2-azanonacosanedioicacid,1-(9-fluren-9-ylmethyl)ester
  Fmoc-N-amido-PEG8-acid
  Fmoc-PEG8-CH2CH2COOH
  Fmoc-PEG8-propionicacid
  Fmoc-NH-(PEG)8-CH2CH2COOH
  1-(9H-Fluoren-9-yl)-3-oxo-2,7,10,13,16,19,22,25,28-nonaoxa-4-azahentriacontan-31-oic acid
  1-(Fmoc-amino)-3,6,9,12,15,18,21,24-octaoxaheptacosan-27-oic acid
  
• Purity：
  ≥95%
• MF：
  C₃₄H₄₉NO₁₂
• MW：
  663.8
• Recommended Storage Condition：
  Store at -5°C,keep in dry and avoid sunlight.
• Uses：
  

Fmoc-N-amido-PEG8-acid (Fmoc-NH-PEG8-COOH) is a PEG derivative containing an Fmoc-protected amine and a terminal carboxylic acid. The hydrophilic PEG spacer increases solubility in aqueous media. The Fmoc group can be deprotected under basic condition to obtain the free amine which can be used for further conjugations. The terminal carboxylic acid can be reacted with primary amine groups in the presence of activators (e.g. EDC, or DCC) to form a stable amide bond.

Numerous applications have used Fmoc-N-amido-PEG8-acid. For example, it is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. 

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References:
[1]. Fulcher JM, et al. Chemical synthesis of Shiga toxin subunit B using a next-generation traceless "helping hand" solubilizing tag. Org Biomol Chem. 2019 Dec 28;17(48):10237-10244.