• Purity：
  ≥95%
• Recommended Storage Condition：
  Store at -5°C,keep in dry and avoid sunlight.
• Uses：
  

DSPE-PEG-Mannose,1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-(polyethyleneglycol)-Mannose (sodium salt) is a phospholipid for drug delivery systems, especially for mRNA vaccine delivery. It is an active target material, which can be used as an antitumor drug carrier and a liposome for targeted delivery. 

Biopharma PEG can provide high purity DSPE-PEG-Mannose in GMP and non-GMP grades. Besides PEG lipids, we can also provide helper lipids, such as cholesterol (plant-derived), and DSPE for your LNP formulation development. Email us at sales@biochempeg.com for more details. 

Cited Publications

This PEG derivative has been cited in peer-reviewed scientific publications. Browse the references below to learn more.

1. Mannose-decorated polymersomes loaded with antigens and TLR7/8 agonists targeting antigen-presenting cells for enhancing vaccine efficacy, J. Lim, S. Lee, H. Park, S. Lee, M. Yeom, S. Haam and D. Song, Mater. Adv., 2025, Advance Article , DOI: 10.1039/D5MA00115C
2. Stanković, T.; Ilić, T.; Divović Matović, B.; Petkovic, M.; Dobričić, V.; Jančić, I.; Bufan, B.; Jezdić, K.; Đoković, J.; Pantelić, I.; et al. Intravenous Nanoemulsions Loaded with Phospholipid Complex of a Novel Pyrazoloquinolinone Ligand for Enhanced Brain Delivery. Pharmaceutics 2025, 17, 232. https://doi.org/10.3390/pharmaceutics17020232 
3. Chengyan Jin, Yan Zhang, Baofeng Li, Tianci Gao, Bin Wang, Peiyan Hua,
   Robust anti-tumor immunity through the integration of targeted lipid nanoparticle-based mRNA nanovaccines with PD-1/PD-L1 blockade, Materials Today Bio, Volume 27, 2024, 101136, ISSN 2590-0064, https://doi.org/10.1016/j.mtbio.2024.101136. 
4. Gregersen CH, Mearraoui R, Søgaard PP, et al. Lipid nanoparticles containing labile PEG-lipids transfect primary human skin cells more efficiently in the presence of apoE. Eur J Pharm Biopharm. 2024;197:114219. doi:10.1016/j.ejpb.2024.114219 
5. Dossou Akpedje S. , Mantsch Morgan E. , Sabnis Nirupama , Berg Rance E. , Fudala Rafal , Lacko Andras G. , Mannose-functionalization of reconstituted high-density lipoprotein nanoparticles improves payload delivery and enhances M2-to-M1 phenotype reprogramming of RAW 264.7 macrophages polarized by B16-F10 melanoma cells, Frontiers in Drug Delivery, Volume 3 - 2023, DOI:10.3389/fddev.2023.1281066 
6. Dossou, A. S., Mantsch, M. E., Kapic, A., Burnett, W. L., Sabnis, N., Coffer, J. L., Berg, R. E., Fudala, R., & Lacko, A. G. (2023). Mannose-Coated Reconstituted Lipoprotein Nanoparticles for the Targeting of Tumor-Associated Macrophages: Optimization, Characterization, and In Vitro Evaluation of Effectiveness. Pharmaceutics, 15(6), 1685. https://doi.org/10.3390/pharmaceutics15061685 
7. Kim, M., Jeong, M., Hur, S., Cho, Y., Park, J., Jung, H., Seo, Y., Woo, H. A., Nam, K. T., Lee, K., & Lee, H. (2021). Engineered ionizable lipid nanoparticles for targeted delivery of RNA therapeutics into different types of cells in the liver. Science Advances. https://doi.org/abf4398

View more publications citing Biopharma PEG products.