• Purity：
  ≥95%
• Recommended Storage Condition：
  Store at -5°C,keep in dry and avoid sunlight.
• Uses：
  

DSPE-PEG-Mannose is a well-defined amphiphilic conjugate designed for biomedical applications that require both structural stability and molecular recognition.  

It is composed of three key parts: DSPE, a hydrophobic lipid anchor; PEG, a hydrophilic spacer; and mannose, a targeting ligand at the terminal end. This structure allows DSPE-PEG-Mannose to self-assemble in aqueous environments and integrate into lipid membranes while maintaining good dispersibility and stability in biological systems.

As a DSPE-PEG-based material, it combines the membrane-binding ability of DSPE with the solubility and steric protection provided by PEG. The mannose group enables specific recognition of mannose receptors on certain cells, such as dendritic cells and macrophages, making it useful in targeted drug delivery, vaccine design, and biomaterial research. Its simple structure and functional design make it a valuable building block for applications that require both biocompatibility and active targeting.

Cited Publications

The DSPE-PEG-Mannose has been cited in peer-reviewed scientific publications. Browse the references below to learn more.

1. Mannose-decorated polymersomes loaded with antigens and TLR7/8 agonists targeting antigen-presenting cells for enhancing vaccine efficacy, J. Lim, S. Lee, H. Park, S. Lee, M. Yeom, S. Haam and D. Song, Mater. Adv., 2025, Advance Article , DOI: 10.1039/D5MA00115C
2. Stanković, T.; Ilić, T.; Divović Matović, B.; Petkovic, M.; Dobričić, V.; Jančić, I.; Bufan, B.; Jezdić, K.; Đoković, J.; Pantelić, I.; et al. Intravenous Nanoemulsions Loaded with Phospholipid Complex of a Novel Pyrazoloquinolinone Ligand for Enhanced Brain Delivery. Pharmaceutics 2025, 17, 232. https://doi.org/10.3390/pharmaceutics17020232 
3. Chengyan Jin, Yan Zhang, Baofeng Li, Tianci Gao, Bin Wang, Peiyan Hua,
   Robust anti-tumor immunity through the integration of targeted lipid nanoparticle-based mRNA nanovaccines with PD-1/PD-L1 blockade, Materials Today Bio, Volume 27, 2024, 101136, ISSN 2590-0064, https://doi.org/10.1016/j.mtbio.2024.101136. 
4. Gregersen CH, Mearraoui R, Søgaard PP, et al. Lipid nanoparticles containing labile PEG-lipids transfect primary human skin cells more efficiently in the presence of apoE. Eur J Pharm Biopharm. 2024;197:114219. doi:10.1016/j.ejpb.2024.114219 
5. Dossou Akpedje S. , Mantsch Morgan E. , Sabnis Nirupama , Berg Rance E. , Fudala Rafal , Lacko Andras G. , Mannose-functionalization of reconstituted high-density lipoprotein nanoparticles improves payload delivery and enhances M2-to-M1 phenotype reprogramming of RAW 264.7 macrophages polarized by B16-F10 melanoma cells, Frontiers in Drug Delivery, Volume 3 - 2023, DOI:10.3389/fddev.2023.1281066 
6. Dossou, A. S., Mantsch, M. E., Kapic, A., Burnett, W. L., Sabnis, N., Coffer, J. L., Berg, R. E., Fudala, R., & Lacko, A. G. (2023). Mannose-Coated Reconstituted Lipoprotein Nanoparticles for the Targeting of Tumor-Associated Macrophages: Optimization, Characterization, and In Vitro Evaluation of Effectiveness. Pharmaceutics, 15(6), 1685. https://doi.org/10.3390/pharmaceutics15061685 
7. Kim, M., Jeong, M., Hur, S., Cho, Y., Park, J., Jung, H., Seo, Y., Woo, H. A., Nam, K. T., Lee, K., & Lee, H. (2021). Engineered ionizable lipid nanoparticles for targeted delivery of RNA therapeutics into different types of cells in the liver. Science Advances. https://doi.org/abf4398

View more publications citing Biopharma PEG products.

Related Technical Articles & Guides

• ● PEG Lipids: Definition, Structure & Key Applications 
• ● The Role of Four Lipid Components Of LNPs
• ● Ultimate Insight into PEG Derivatives and Its Application

Related Products & Categories

• ● Category: Lipids for Lipid Nanoparticles (LNPs)
• ● Phospholipid Building Block: DSPE , DPPE
• ● PEG Lipids:  mPEG-DSPE, mPEG-DMG 
• ● Functionalized PEG Lipids:  DSPE-PEG-NH2, DSPE-PEG-MAL , DSPE-PEG-NHS
• ● Targeting PEG Lipids: DSPE-PEG-c(RGDyk) 
• ● Other LNP Lipids: Cholesterol (Plant-Derived)