• Purity：
  ≥90%
• Recommended Storage Condition：
  Store at -5°C,keep in dry and avoid sunlight.
• Uses：
  Applicated in medical research, drug-release, nanotechnology and new materials research, cell culture. In the study of ligand, polypeptide synthesis support, a graft polymer compounds, new materials, and polyethylene glycol-modified functional coatings and other aspects of the active compound.

DSPE-PEG-c(RGDyK) is a targeted lipid-PEG conjugate combining 1,2-distearoyl-sn-glycero-3-phosphoethanolamine (DSPE) with a PEG linker and a cyclic RGD (c(RGDyK)) peptide. The DSPE moiety anchors into lipid membranes, while the PEG chain provides steric stabilization and “stealth” properties. The c(RGDyK) peptide targets integrin receptors (e.g. α_vβ_3) overexpressed in tumor angiogenesis, enabling active targeting of drug carriers such as liposomes, nanoparticles, or micelles. This functional lipid is widely used in targeted drug delivery, tumor imaging, and ligand-decorated nanocarrier systems.

Cited Publications

Our DSPE-PEG-c(RGDyK) has been cited in peer-reviewed scientific publications. Browse the references below to learn more.

1. Neutrophil Hitchhiking Enhances Liposomal Dexamethasone Therapy of Sepsis, Ritvik Mathur, Sara Elsafy, Adrian T. Press, Julian Brück, Mathias Hornef, Lukas Martin, Tobias Schürholz, Gernot Marx, Matthias Bartneck, Fabian Kiessling, Josbert Maarten Metselaar, Gert Storm, Twan Lammers, Alexandros Marios Sofias, and Patrick Koczera, ACS Nano 2024 18 (42), 28866-28880,  DOI: 10.1021/acsnano.4c09054
2. Lubitz, L.J.; Haffner, M.P.; Rieger, H.; Leneweit, G. Increased Cellular Uptake of ApoE3- or c(RGD)-Modified Liposomes for Glioblastoma Therapy Depending on the Target Cells. Pharmaceutics 2024, 16, 1112. https://doi.org/10.3390/pharmaceutics16091112 
3. Niederauer, C., Nguyen, C., Wang-Henderson, M. et al. Dual-color DNA-PAINT single-particle tracking enables extended studies of membrane protein interactions. Nat Commun 14, 4345 (2023). https://doi.org/10.1038/s41467-023-40065-8

View more publications citing Biopharma PEG products.

Related Technical Articles & Guides

• ● PEG Lipids: Definition, Structure & Key Applications 
• ● The Role of Four Lipid Components Of LNPs
• ● Ultimate Insight into PEG Derivatives and Its Application

Related Products & Categories

• ● Category: Lipids for Lipid Nanoparticles (LNPs) | DSPE PEG
• ● Phospholipid Building Block: DSPE , DPPE
• ● PEG Lipids:  mPEG-DSPE, mPEG-DMG 
• ● Functionalized PEG Lipids: DSPE-PEG-MAL , DSPE-PEG-NH2, DSPE-PEG-NHS
• ● Targeting PEG Lipids:  DSPE-PEG-Mannose, DSPE-PEG-Galactose, DSPE-PEG-Glucose, DSPE-PEG-RGD
• ● Other LNP Lipids: Cholesterol (Plant-Derived)