• CAS No.：
  9004-74-4
• Synonyms：
  mPEG-Hydroxy
  Polyethylene glycol monomethyl ether
  Methoxypolyethylene glycols
  
• Purity：
  ≥95%
• Recommended Storage Condition：
  Store at -5°C,keep in dry and avoid sunlight.
• Uses：
  

mPEG-OH is a linear monofunctional Methoxy PEG reagent containing a methoxy (CH3O)-capped polyethylene glycol with one hydroxyl group. It is one of the most common PEG raw materials for further derivatization or functionalization to prepare other reactive functional groups on PEG.

mPEG-OH  holds significant promise across various fields, including peptide synthesis, targeted drug delivery, and controlled-release systems. By modifying therapeutic molecules, mPEG-OH enhances drug stability, extends circulation time, and reduces immune clearance, a capability already proven in commercial PEGylated drugs such as PEG-Interferon and PEG-GCSF. Beyond pharmaceuticals, it is a versatile tool in material science, serving as a surface modifier to improve the hydrophilicity and biocompatibility of biomedical materials, cosmetics, and personal care products.

Biopharma PEG offers a wide range of Methoxy PEG products from lab to commercial scale in both non-GMP and GMP grades. Email at [email protected] and start using a superior product for your next product R&D project.
Find More monodispersed methoxy PEGs on our catalog, such as mPEGn-PEG, mPEGn-COOH, mPEGn-NH2, mPEGn-SH, etc. 

Cited Publications

This PEG derivative has been cited in peer-reviewed scientific publications. Browse the references below to learn more.

1. AFM-Based Single-Molecule Force Spectroscopy of PEG–Anti-PEG Antibody Interactions, Glenn Villena Latag, Hiroyuki Tahara, Airi Katase, Shoichi Maeda, Yiwei Liu, Yoshimitsu Kakuta, Takamasa Teramoto, Takeshi Mori, and Tomohiro Hayashi, ACS Applied Bio Materials Article ASAP, DOI: 10.1021/acsabm.5c01967
2. Shortwave Infrared Hemicyanine-6 for Cancer-Activated and Shaving-Free Preclinical Imaging of Lung Metastasis, Hanyu Yang, Donghao Li, Jiayan Wu, and Kanyi Pu, Journal of the American Chemical Society Article ASAP, DOI: 10.1021/jacs.5c06682
3. Kuddushi M, Pawar A, Sharaf MG, Unsworth L, Zhang X. Evaluating electrospun polycaprolactone fibers for blood-contacting applications. ChemRxiv. 2025; doi:10.26434/chemrxiv-2025-qvt7v 
4. Yu, J., Wu, J., Huang, J. et al. Hypoxia-tolerant polymeric photosensitizer prodrug for cancer photo-immunotherapy. Nat Commun 16, 153 (2025). https://doi.org/10.1038/s41467-024-55529-8 
5. Y. Li, J. F. Scheerstra, Y. Liu, A. C. Wauters, J. Wang, H. Wu, T. Patiño, A. Llopis-Lorente, J. C. M. van Hest, L. K. E. A. Abdelmohsen, J. Polym. Sci. 2024, 62(10), 2215. https://doi.org/10.1002/pol.20230941

View more publications citing Biopharma PEG products.