• Synonyms：
  Methoxy-PEG-Silane
  
• Purity：
  ≥95%
• Recommended Storage Condition：
  Store at -5°C,keep in dry and avoid sunlight.
• Uses：
  Applicated in medical research, drug-release, nanotechnology and new materials research, cell culture. In the study of ligand, polypeptide synthesis support, a graft polymer compounds, new materials, and polyethylene glycol-modified functional coatings and other aspects of the active compound.

mPEG-Silane (Methoxy PEG Silane) is a linear monofunctional mPEG derivative containing an inert methoxy (-OCH3) end cap and a reactive alkoxysilane or triethoxysilane terminal group.  The silane moiety undergoes hydrolytic condensation with surface hydroxyl (-OH) groups on glass substrates, quartz, silicon wafers, titanium dioxide (TiO2), and metal oxides.   It is a premier silanization reagent designed for covalent surface modification, nanoparticle functionalization, and anti-biofouling PEG coatings across inorganic and polymeric substrates.

Cited Publications

The Methoxy PEG silane derivative has been cited in peer-reviewed scientific publications. Browse the references below to learn more.

1. Happonen, Emilia; Dang, Yijing; Wang, Jiajia; Saarela, Silja; Sivonen, Minna; Zakir, Mohammed; et al. (2025). Drug-Free Approach to Regulate Undruggable Proto-Oncogene
   MYC Using Biomimetic Porous Nanoparticles for Cancer Immunotherapy. ACS Publications. Journal contribution. https://doi.org/10.1021/acsami.5c05042.s001
2. NMR studies of PEG chain dynamics on mesoporous silica nanoparticles for minimizing non-specific binding, Xiaochong Li,  Yang Liu, Edmond C. N. Wong and  Mitchell A. Winnik,  Nanoscale, 2025,17, 14759-14771, https://doi.org/10.1039/D5NR00936G
3. Wen, J.; Lei, C.; Hua, S.; Cai, L.R.Y.; Dai, H.; Liu, S.Y.; Li, Y.W.; Ivanovski, S.; Xu, C. Regulation of macrophage uptake through the bio-nano interaction using surface functionalized mesoporous silica nanoparticles with large radial pores. J. Mater. Chem. B 2024, 13, 137–150. https://doi.org/10.1039/D4TB01124D 
4. Daichi Nakajima, Nozomi Takahashi, Takanari Inoue, Shin-ichiro M. Nomura, Hideaki T. Matsubayashi,
   A unified purification method for actin-binding proteins using a TEV-cleavable His-Strep-tag, MethodsX, Volume 13, 2024, 102884, ISSN 2215-0161, https://doi.org/10.1016/j.mex.2024.102884. 
5. Wen H, Martínez MG, Happonen E, et al. A PEG-assisted membrane coating to prepare biomimetic mesoporous silicon for PET/CT imaging of triple-negative breast cancer. Int J Pharm. 2024;652:123764. doi:10.1016/j.ijpharm.2023.123764 
6. Wen, H.; Poutiainen, P.; Batnasan, E.; Latonen, L.; Lehto, V.-P.; Xu, W. Biomimetic Inorganic Nanovectors as Tumor-Targeting Theranostic Platform against Triple-Negative Breast Cancer. Pharmaceutics 2023, 15, 2507. https://doi.org/10.3390/pharmaceutics15102507 
7. Nonviral base editing of KCNJ13 mutation preserves vision in a model of inherited retinal channelopathy, Published in Volume 133, Issue 19 on October 2, 2023J Clin Invest. 2023;133(19):e171356. https://doi.org/10.1172/JCI171356. 
8. Sekine, R., Tsuno, S., Irokawa, H., Sumitomo, K., Han, T., Sato, Y., Nishizawa, S., Takeda, K., & Kuge, S. (2023). Inhibition of SARS-CoV-2 nucleocapsid protein–RNA interaction by guanosine oligomeric RNA. The Journal of Biochemistry, 173(6), 447-457. https://doi.org/10.1093/jb/mvad008 
9. Functionalized silica nanoplatform as a bimodal contrast agent for MRI and optical imaging, Nanoscale, 2021,13, 16509-16524, https://doi.org/10.1039/D1NR04972K
10. ​Wack, M., Wiegand, T., Frischknecht, F. and Cavalcanti-Adam, E. A. (2020). An in vitro DNA Sensor-based Assay to Measure Receptor-specific Adhesion Forces of Eukaryotic Cells and Pathogens. Bio-protocol 10(17): e3733. DOI: 10.21769/BioProtoc.3733. 
11. Lee, J., Choi, S. W., Park, M., Um, W., Kwon, S., Kim, C. H., Joo, H., You, D. G., Lee, J. A., Shin, S., Kang, H., Ghahari, F., Kim, J., & Park, J. H. (2025). Hematite-embedded mesoporous nanoparticles for ferroptosis-inducing cancer sonoimmunotherapy. Journal of Controlled Release, 113990. https://doi.org/10.1016/j.jconrel.2025.113990

View more publications citing Biopharma PEG products.

Related Products & Categories

• ● Category: Monofunctional mPEG Derivatives | Polydispersed Silane PEGs
• ● Hydroxyl Precursor: mPEG-OH
• ● Amine-Reactive mPEGs: mPEG-NHS | mPEG-PALD
• ●Thiol & Functional mPEGs: mPEG-Br | mPEG-SH 
• ● Amine & Azide mPEGs: mPEG-NH2 | mPEG-Azide​
• ● Silane Functional PEGs: Silane-PEG-NHS | Silane-PEG-OH | Silane-PEG-COOH | Silane-PEG-NH2 | Silane-PEG-Biotin